What is the ICD-10-CM code for SIRS?

The primary ICD-10-CM code for SIRS is R65.10 (Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction). There are 7 billable SIRS codes in FY2027, covering different types and underlying causes.

How many ICD-10-CM codes are there for SIRS?

There are 8 ICD-10-CM codes for SIRS in the FY2027 tabular list, of which 7 are billable. These codes fall under Chapter 18 of the ICD-10-CM classification.

Which chapter covers SIRS in ICD-10-CM?

SIRS (Systemic Inflammatory Response Syndrome) codes are classified in Chapter 18 of the ICD-10-CM tabular list: R00–R99 (Symptoms, Signs and Abnormal Clinical and Laboratory Findings).

SIRS (Systemic Inflammatory Response Syndrome) ICD-10-CM codes

ICD-10-CM codes for systemic inflammatory response syndrome (SIRS) of non-infectious origin, with and without acute organ dysfunction.

8 codes, 7 billable. FY2027, valid from October 1, 2026. In chapter 18: Symptoms, Signs and Abnormal Clinical and Laboratory Findings.

How to code SIRS (Systemic Inflammatory Response Syndrome)

R65.1- is reserved for SIRS of non-infectious origin, such as SIRS after trauma, burns, or pancreatitis. R65.10 is without acute organ dysfunction and R65.11 is with acute organ dysfunction. The underlying condition is sequenced first, for example K85.90 for acute pancreatitis or an injury code, and R65.1- is never the principal diagnosis.

With R65.11, add codes for each organ dysfunction, such as N17.9 acute kidney injury or J96.00 acute respiratory failure. If an infection is the cause, R65.1- is not used: the case is coded as sepsis, for example A41.9 with R65.20 when there is organ dysfunction.

All SIRS (Systemic Inflammatory Response Syndrome) codes

More Condition Guides

Diabetes Mellitus Hypertension Pneumonia COPD Asthma Chronic Kidney Disease Heart Failure Atrial Fibrillation Sepsis GERD Urinary Tract Infection Stroke (Cerebral Infarction)All 335 guides