All ICD10 Codes
Chapter 3

D50–D89: Diseases of the Blood and Blood-Forming Organs

Diseases of the Blood and Blood-Forming Organs diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
All CodesBillable Only
Internal Codes
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  • D78.89—

    Other postprocedural complications of the spleen

  • D80—

    Immunodeficiency with predominantly antibody defects

  • D80.0—

    Hereditary hypogammaglobulinemia

  • D80.1—

    Nonfamilial hypogammaglobulinemia

  • D80.2—

    Selective deficiency of immunoglobulin A [IgA]

  • D80.3—

    Selective deficiency of immunoglobulin G [IgG] subclasses

  • D80.4—

    Selective deficiency of immunoglobulin M [IgM]

  • D80.5—

    Immunodeficiency with increased immunoglobulin M [IgM]

  • D80.6—

    Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

  • D80.7—

    Transient hypogammaglobulinemia of infancy

  • D80.8—

    Other immunodeficiencies with predominantly antibody defects

  • D80.9—

    Immunodeficiency with predominantly antibody defects, unspecified

  • D81—

    Combined immunodeficiencies

  • D81.0—

    Severe combined immunodeficiency [SCID] with reticular dysgenesis

  • D81.1—

    Severe combined immunodeficiency [SCID] with low T- and B-cell numbers

  • D81.2—

    Severe combined immunodeficiency [SCID] with low or normal B-cell numbers

  • D81.3—

    Adenosine deaminase [ADA] deficiency

  • D81.30—

    Adenosine deaminase deficiency, unspecified

  • D81.31—

    Severe combined immunodeficiency due to adenosine deaminase deficiency

  • D81.32—

    Adenosine deaminase 2 deficiency

  • D81.39—

    Other adenosine deaminase deficiency

  • D81.4—

    Nezelof's syndrome

  • D81.5—

    Purine nucleoside phosphorylase [PNP] deficiency

  • D81.6—

    Major histocompatibility complex class I deficiency

  • D81.7—

    Major histocompatibility complex class II deficiency

  • D81.8—

    Other combined immunodeficiencies

  • D81.81—

    Biotin-dependent carboxylase deficiency

  • D81.810—

    Biotinidase deficiency

  • D81.818—

    Other biotin-dependent carboxylase deficiency

  • D81.819—

    Biotin-dependent carboxylase deficiency, unspecified

  • D81.82—

    Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

  • D81.89—

    Other combined immunodeficiencies

  • D81.9—

    Combined immunodeficiency, unspecified

  • D82—

    Immunodeficiency associated with other major defects

  • D82.0—

    Wiskott-Aldrich syndrome

  • D82.1—

    Di George's syndrome

  • D82.2—

    Immunodeficiency with short-limbed stature

  • D82.3—

    Immunodeficiency following hereditary defective response to Epstein-Barr virus

  • D82.4—

    Hyperimmunoglobulin E [IgE] syndrome

  • D82.8—

    Immunodeficiency associated with other specified major defects

  • D82.9—

    Immunodeficiency associated with major defect, unspecified

  • D83—

    Common variable immunodeficiency

  • D83.0—

    Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function

  • D83.1—

    Common variable immunodeficiency with predominant immunoregulatory T-cell disorders

  • D83.2—

    Common variable immunodeficiency with autoantibodies to B- or T-cells

  • D83.8—

    Other common variable immunodeficiencies

  • D83.9—

    Common variable immunodeficiency, unspecified

  • D84—

    Other immunodeficiencies

  • D84.0—

    Lymphocyte function antigen-1 [LFA-1] defect

  • D84.1—

    Defects in the complement system

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