All ICD10 Codes

D81

Non-Billable
ChapterD50–D89
Rankcategory
Official Description

Combined immunodeficiencies

Use a more specific code (8 billable, 2 non-billable)
D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesisD81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbersD81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbersD81.3Adenosine deaminase [ADA] deficiencyhas subcodesD81.4Nezelof's syndromeD81.5Purine nucleoside phosphorylase [PNP] deficiencyD81.6Major histocompatibility complex class I deficiencyD81.7Major histocompatibility complex class II deficiencyD81.8Other combined immunodeficiencieshas subcodesD81.9Combined immunodeficiency, unspecified
Metadata & Insights
  • •Non-billable category (requires more specific sub-code).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

CH3 Parent Instructions

Excludes2(Not included here. Code separately if applicable.)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

D80-D89 Parent Instructions

Includes
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis
Excludes1(Not coded here. Use a different code.)
  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)
  • human immunodeficiency virus [HIV] disease (B20)

Instructional Notes

Excludes1(Not coded here. Use a different code.)
  • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Clinical Hierarchy

BillableHas subcodes
CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D80-D89Certain disorders involving the immune mechanism (D80-D89)
D81Combined immunodeficienciesNot billable
D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesisBillable
D81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbersBillable
D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbersBillable
D81.3Adenosine deaminase [ADA] deficiencySubcodes
D81.4Nezelof's syndromeBillable
D81.5Purine nucleoside phosphorylase [PNP] deficiencyBillable
D81.6Major histocompatibility complex class I deficiencyBillable
D81.7Major histocompatibility complex class II deficiencyBillable
D81.8Other combined immunodeficienciesSubcodes
D81.9Combined immunodeficiency, unspecifiedBillable

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D81:

blockD80-D89
Certain disorders involving the immune mechanism (D80-D89)
View context instructions
chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

MS-DRG Classification

2026

No direct MS-DRG triggers identified.

Cross Reference

Find Procedures (ICD-10-PCS)

Find surgical and procedural codes related to Combined immunodeficiencies.

Search PCS Codes