All ICD10 Codes

D81.82

Billable
ChapterD50–D89
Ranksubcategory
Official Description

Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

Metadata & Insights
  • •Billable/specific code (valid for reimbursement).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

Instructional Notes

Includes
  • p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease
Code Also
  • , if applicable, any associated manifestations, such as:
  • bronchiectasis (J47.-)
  • herpes virus infections (B00.-)
  • other acute respiratory tract infections (J00-J06; J20-J22)
  • other infections (A00-B99)
  • pneumonia (J12-J18)
General instructions are available for the parent sections:
View CH3 NotesView D80-D89 NotesView D81 Notes

Clinical Hierarchy

BillableHas subcodes
CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D80-D89Certain disorders involving the immune mechanism (D80-D89)
D81Combined immunodeficiencies
D81.8Other combined immunodeficiencies
D81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]Billable

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D81.82:

categoryD81
Combined immunodeficiencies
View context instructions
blockD80-D89
Certain disorders involving the immune mechanism (D80-D89)
View context instructions
chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Code History

  • FY 2022: This code replaced D81.89 (Other combined immunodeficiencies)

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 808
Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC
DRG 809
Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC
DRG 810
Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC

Cross Reference

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