Immunodeficiency with predominantly antibody defects
In Certain disorders involving the immune mechanism (D80-D89), chapter 3: Diseases of the Blood and Blood-Forming Organs
10 billable codes under D80: all are a CC; 5 map to HCC 115 (Specified Immunodeficiencies and White Blood Cell Disorders).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Instructional notes
Also applies, from Certain disorders involving the immune mechanism (D80-D89)
These notes sit on D80-D89 and apply to every code under it, including D80.
Includes: conditions that are coded here
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes1: not coded here, use a different code
Excludes2: not included here, code separately if applicable
- human immunodeficiency virus [HIV] disease (B20)
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
There are no chapter-specific rules for Chapter 3 yet, so the general rules in Section I.B apply.
All codes under D80
D80 can't be used on a claim. Pick a billable code below; grey headings group them.
- D80.0Hereditary hypogammaglobulinemia
- D80.1Nonfamilial hypogammaglobulinemia
- D80.2Selective deficiency of immunoglobulin A [IgA]
- D80.3Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4Selective deficiency of immunoglobulin M [IgM]
- D80.5Immunodeficiency with increased immunoglobulin M [IgM]
- D80.6Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- D80.7Transient hypogammaglobulinemia of infancy
- D80.8Other immunodeficiencies with predominantly antibody defects
- D80.9Immunodeficiency with predominantly antibody defects, unspecified
D80 MS-DRGs
As the principal diagnosis, the billable codes under D80 group to MS-DRG 814, 815, 816, 808, 809, or 810 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 814 Reticuloendothelial and Immunity Disorders with MCC (7 of 10 codes)
- DRG 815 Reticuloendothelial and Immunity Disorders with CC (7 of 10 codes)
- DRG 816 Reticuloendothelial and Immunity Disorders without CC/MCC (7 of 10 codes)
- DRG 808 Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC (3 of 10 codes)
- DRG 809 Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC (3 of 10 codes)
- DRG 810 Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC (3 of 10 codes)
Other codes that refer to D80
Notes on these codes point to D80.
Code history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.