Poisoning, Adverse Effects, and Underdosing ICD-10-CM codes
ICD-10-CM coding structure for drugs and medicaments (T36 to T50), illustrated with acetaminophen, opioids, fentanyl, benzodiazepines, and unspecified drugs: how the intent character separates poisoning, adverse effect, and underdosing, and how each is sequenced.
190 codes, 137 billable. FY2027, valid from October 1, 2026. In chapter 19: Injury, Poisoning and Certain Other Consequences of External Causes.
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How to code Poisoning, Adverse Effects, and Underdosing
Every code in T36 through T50 identifies the drug in the fourth and fifth characters and then reports the circumstance in the sixth: 1 accidental (unintentional) poisoning, 2 intentional self-harm, 3 assault, 4 undetermined, 5 adverse effect, 6 underdosing. When the drug subcategory has only four characters, X fills the fifth, as in T39.1X1A (acetaminophen poisoning, accidental) or T42.4X1A (benzodiazepines). The seventh character is A initial, D subsequent, or S sequela. Undetermined intent (4) is used only when the record states the intent could not be determined; when intent is simply not documented, the default is accidental.
Poisoning means the drug was taken in error, in overdose, by the wrong person, or with alcohol or another drug it should not be combined with. The T code is sequenced first, followed by the manifestations. Opioid overdoses illustrate the drug axis: T40.2X1A other opioids such as oxycodone and hydrocodone, T40.411A fentanyl, T40.1X1A heroin, T40.601A unspecified narcotic; add the F11 code for opioid use, abuse, or dependence (F11.20) when documented. T50.901A is the accidental poisoning code for an unspecified drug.
An adverse effect is a reaction to a drug that was correctly prescribed and properly taken. The manifestation is sequenced first (for example L27.0 for a drug eruption), followed by the T code with the character 5 (T36.0X5A penicillins, T39.395A other NSAIDs, T50.905A unspecified drug). T88.7XXA is the unspecified adverse effect of a drug, and T88.6XXA is anaphylaxis from a correctly administered drug. Underdosing (character 6) means the patient took less than prescribed; it is never a principal diagnosis. Code the condition that worsened first, then the underdosing code, then a Z91.12- or Z91.13- code for the reason (Z91.120 intentional due to financial hardship, Z91.128 other intentional, Z91.130 unintentional due to age-related debility).
All Poisoning, Adverse Effects, and Underdosing codes
- F11.20Opioid dependence, uncomplicated
- L27.0Generalized skin eruption due to drugs and medicaments taken internally
- T36.0X5AAdverse effect of penicillins, initial encounter
- T39.1Poisoning by, adverse effect of and underdosing of 4-Aminophenol derivatives
- T39.1XPoisoning by, adverse effect of and underdosing of 4-Aminophenol derivatives
- T39.1X1Poisoning by 4-Aminophenol derivatives, accidental (unintentional)
- T39.1X1APoisoning by 4-Aminophenol derivatives, accidental (unintentional), initial encounter
- T39.1X1DPoisoning by 4-Aminophenol derivatives, accidental (unintentional), subsequent encounter
- T39.1X1SPoisoning by 4-Aminophenol derivatives, accidental (unintentional), sequela
- T39.1X2Poisoning by 4-Aminophenol derivatives, intentional self-harm
- T39.1X2APoisoning by 4-Aminophenol derivatives, intentional self-harm, initial encounter
- T39.1X2DPoisoning by 4-Aminophenol derivatives, intentional self-harm, subsequent encounter
- T39.1X2SPoisoning by 4-Aminophenol derivatives, intentional self-harm, sequela
- T39.1X3Poisoning by 4-Aminophenol derivatives, assault
- T39.1X3APoisoning by 4-Aminophenol derivatives, assault, initial encounter
- T39.1X3DPoisoning by 4-Aminophenol derivatives, assault, subsequent encounter
- T39.1X3SPoisoning by 4-Aminophenol derivatives, assault, sequela
- T39.1X4Poisoning by 4-Aminophenol derivatives, undetermined
- T39.1X4APoisoning by 4-Aminophenol derivatives, undetermined, initial encounter
- T39.1X4DPoisoning by 4-Aminophenol derivatives, undetermined, subsequent encounter
- T39.1X4SPoisoning by 4-Aminophenol derivatives, undetermined, sequela
- T39.1X5Adverse effect of 4-Aminophenol derivatives
- T39.1X5AAdverse effect of 4-Aminophenol derivatives, initial encounter
- T39.1X5DAdverse effect of 4-Aminophenol derivatives, subsequent encounter
- T39.1X5SAdverse effect of 4-Aminophenol derivatives, sequela
- T39.1X6Underdosing of 4-Aminophenol derivatives
- T39.1X6AUnderdosing of 4-Aminophenol derivatives, initial encounter
- T39.1X6DUnderdosing of 4-Aminophenol derivatives, subsequent encounter
- T39.1X6SUnderdosing of 4-Aminophenol derivatives, sequela
- T39.395AAdverse effect of other nonsteroidal anti-inflammatory drugs [NSAID], initial encounter
- T40.1X1APoisoning by heroin, accidental (unintentional), initial encounter
- T40.2Poisoning by, adverse effect of and underdosing of other opioids
- T40.2XPoisoning by, adverse effect of and underdosing of other opioids
- T40.2X1Poisoning by other opioids, accidental (unintentional)
- T40.2X1APoisoning by other opioids, accidental (unintentional), initial encounter
- T40.2X1DPoisoning by other opioids, accidental (unintentional), subsequent encounter
- T40.2X1SPoisoning by other opioids, accidental (unintentional), sequela
- T40.2X2Poisoning by other opioids, intentional self-harm
- T40.2X2APoisoning by other opioids, intentional self-harm, initial encounter
- T40.2X2DPoisoning by other opioids, intentional self-harm, subsequent encounter
- T40.2X2SPoisoning by other opioids, intentional self-harm, sequela
- T40.2X3Poisoning by other opioids, assault
- T40.2X3APoisoning by other opioids, assault, initial encounter
- T40.2X3DPoisoning by other opioids, assault, subsequent encounter
- T40.2X3SPoisoning by other opioids, assault, sequela
- T40.2X4Poisoning by other opioids, undetermined
- T40.2X4APoisoning by other opioids, undetermined, initial encounter
- T40.2X4DPoisoning by other opioids, undetermined, subsequent encounter
- T40.2X4SPoisoning by other opioids, undetermined, sequela
- T40.2X5Adverse effect of other opioids
- T40.2X5AAdverse effect of other opioids, initial encounter
- T40.2X5DAdverse effect of other opioids, subsequent encounter
- T40.2X5SAdverse effect of other opioids, sequela
- T40.2X6Underdosing of other opioids
- T40.2X6AUnderdosing of other opioids, initial encounter
- T40.2X6DUnderdosing of other opioids, subsequent encounter
- T40.2X6SUnderdosing of other opioids, sequela
- T40.4Poisoning by, adverse effect of and underdosing of other synthetic narcotics
- T40.41Poisoning by, adverse effect of and underdosing of fentanyl or fentanyl analogs
- T40.411Poisoning by fentanyl or fentanyl analogs, accidental (unintentional)
- T40.411APoisoning by fentanyl or fentanyl analogs, accidental (unintentional), initial encounter
- T40.411DPoisoning by fentanyl or fentanyl analogs, accidental (unintentional), subsequent encounter
- T40.411SPoisoning by fentanyl or fentanyl analogs, accidental (unintentional), sequela
- T40.412Poisoning by fentanyl or fentanyl analogs, intentional self-harm
- T40.412APoisoning by fentanyl or fentanyl analogs, intentional self-harm, initial encounter
- T40.412DPoisoning by fentanyl or fentanyl analogs, intentional self-harm, subsequent encounter
- T40.412SPoisoning by fentanyl or fentanyl analogs, intentional self-harm, sequela
- T40.413Poisoning by fentanyl or fentanyl analogs, assault
- T40.413APoisoning by fentanyl or fentanyl analogs, assault, initial encounter
- T40.413DPoisoning by fentanyl or fentanyl analogs, assault, subsequent encounter
- T40.413SPoisoning by fentanyl or fentanyl analogs, assault, sequela
- T40.414Poisoning by fentanyl or fentanyl analogs, undetermined
- T40.414APoisoning by fentanyl or fentanyl analogs, undetermined, initial encounter
- T40.414DPoisoning by fentanyl or fentanyl analogs, undetermined, subsequent encounter
- T40.414SPoisoning by fentanyl or fentanyl analogs, undetermined, sequela
- T40.415Adverse effect of fentanyl or fentanyl analogs
- T40.415AAdverse effect of fentanyl or fentanyl analogs, initial encounter
- T40.415DAdverse effect of fentanyl or fentanyl analogs, subsequent encounter
- T40.415SAdverse effect of fentanyl or fentanyl analogs, sequela
- T40.416Underdosing of fentanyl or fentanyl analogs
- T40.416AUnderdosing of fentanyl or fentanyl analogs, initial encounter
- T40.416DUnderdosing of fentanyl or fentanyl analogs, subsequent encounter
- T40.416SUnderdosing of fentanyl or fentanyl analogs, sequela
- T40.42Poisoning by, adverse effect of and underdosing of tramadol
- T40.421Poisoning by tramadol, accidental (unintentional)
- T40.421APoisoning by tramadol, accidental (unintentional), initial encounter
- T40.421DPoisoning by tramadol, accidental (unintentional), subsequent encounter
- T40.421SPoisoning by tramadol, accidental (unintentional), sequela
- T40.422Poisoning by tramadol, intentional self-harm
- T40.422APoisoning by tramadol, intentional self-harm, initial encounter
- T40.422DPoisoning by tramadol, intentional self-harm, subsequent encounter
- T40.422SPoisoning by tramadol, intentional self-harm, sequela
- T40.423Poisoning by tramadol, assault
- T40.423APoisoning by tramadol, assault, initial encounter
- T40.423DPoisoning by tramadol, assault, subsequent encounter
- T40.423SPoisoning by tramadol, assault, sequela
- T40.424Poisoning by tramadol, undetermined
- T40.424APoisoning by tramadol, undetermined, initial encounter
- T40.424DPoisoning by tramadol, undetermined, subsequent encounter
- T40.424SPoisoning by tramadol, undetermined, sequela
- T40.425Adverse effect of tramadol
- T40.425AAdverse effect of tramadol, initial encounter
- T40.425DAdverse effect of tramadol, subsequent encounter
- T40.425SAdverse effect of tramadol, sequela
- T40.426Underdosing of tramadol
- T40.426AUnderdosing of tramadol, initial encounter
- T40.426DUnderdosing of tramadol, subsequent encounter
- T40.426SUnderdosing of tramadol, sequela
- T40.49Poisoning by, adverse effect of and underdosing of other synthetic narcotics
- T40.491Poisoning by other synthetic narcotics, accidental (unintentional)
- T40.491APoisoning by other synthetic narcotics, accidental (unintentional), initial encounter
- T40.491DPoisoning by other synthetic narcotics, accidental (unintentional), subsequent encounter
- T40.491SPoisoning by other synthetic narcotics, accidental (unintentional), sequela
- T40.492Poisoning by other synthetic narcotics, intentional self-harm
- T40.492APoisoning by other synthetic narcotics, intentional self-harm, initial encounter
- T40.492DPoisoning by other synthetic narcotics, intentional self-harm, subsequent encounter
- T40.492SPoisoning by other synthetic narcotics, intentional self-harm, sequela
- T40.493Poisoning by other synthetic narcotics, assault
- T40.493APoisoning by other synthetic narcotics, assault, initial encounter
- T40.493DPoisoning by other synthetic narcotics, assault, subsequent encounter
- T40.493SPoisoning by other synthetic narcotics, assault, sequela
- T40.494Poisoning by other synthetic narcotics, undetermined
- T40.494APoisoning by other synthetic narcotics, undetermined, initial encounter
- T40.494DPoisoning by other synthetic narcotics, undetermined, subsequent encounter
- T40.494SPoisoning by other synthetic narcotics, undetermined, sequela
- T40.495Adverse effect of other synthetic narcotics
- T40.495AAdverse effect of other synthetic narcotics, initial encounter
- T40.495DAdverse effect of other synthetic narcotics, subsequent encounter
- T40.495SAdverse effect of other synthetic narcotics, sequela
- T40.496Underdosing of other synthetic narcotics
- T40.496AUnderdosing of other synthetic narcotics, initial encounter
- T40.496DUnderdosing of other synthetic narcotics, subsequent encounter
- T40.496SUnderdosing of other synthetic narcotics, sequela
- T40.601APoisoning by unspecified narcotics, accidental (unintentional), initial encounter
- T42.4Poisoning by, adverse effect of and underdosing of benzodiazepines
- T42.4XPoisoning by, adverse effect of and underdosing of benzodiazepines
- T42.4X1Poisoning by benzodiazepines, accidental (unintentional)
- T42.4X1APoisoning by benzodiazepines, accidental (unintentional), initial encounter
- T42.4X1DPoisoning by benzodiazepines, accidental (unintentional), subsequent encounter
- T42.4X1SPoisoning by benzodiazepines, accidental (unintentional), sequela
- T42.4X2Poisoning by benzodiazepines, intentional self-harm
- T42.4X2APoisoning by benzodiazepines, intentional self-harm, initial encounter
- T42.4X2DPoisoning by benzodiazepines, intentional self-harm, subsequent encounter
- T42.4X2SPoisoning by benzodiazepines, intentional self-harm, sequela
- T42.4X3Poisoning by benzodiazepines, assault
- T42.4X3APoisoning by benzodiazepines, assault, initial encounter
- T42.4X3DPoisoning by benzodiazepines, assault, subsequent encounter
- T42.4X3SPoisoning by benzodiazepines, assault, sequela
- T42.4X4Poisoning by benzodiazepines, undetermined
- T42.4X4APoisoning by benzodiazepines, undetermined, initial encounter
- T42.4X4DPoisoning by benzodiazepines, undetermined, subsequent encounter
- T42.4X4SPoisoning by benzodiazepines, undetermined, sequela
- T42.4X5Adverse effect of benzodiazepines
- T42.4X5AAdverse effect of benzodiazepines, initial encounter
- T42.4X5DAdverse effect of benzodiazepines, subsequent encounter
- T42.4X5SAdverse effect of benzodiazepines, sequela
- T42.4X6Underdosing of benzodiazepines
- T42.4X6AUnderdosing of benzodiazepines, initial encounter
- T42.4X6DUnderdosing of benzodiazepines, subsequent encounter
- T42.4X6SUnderdosing of benzodiazepines, sequela
- T50.90Poisoning by, adverse effect of and underdosing of unspecified drugs, medicaments and biological substances
- T50.901Poisoning by unspecified drugs, medicaments and biological substances, accidental (unintentional)
- T50.901APoisoning by unspecified drugs, medicaments and biological substances, accidental (unintentional), initial encounter
- T50.901DPoisoning by unspecified drugs, medicaments and biological substances, accidental (unintentional), subsequent encounter
- T50.901SPoisoning by unspecified drugs, medicaments and biological substances, accidental (unintentional), sequela
- T50.902Poisoning by unspecified drugs, medicaments and biological substances, intentional self-harm
- T50.902APoisoning by unspecified drugs, medicaments and biological substances, intentional self-harm, initial encounter
- T50.902DPoisoning by unspecified drugs, medicaments and biological substances, intentional self-harm, subsequent encounter
- T50.902SPoisoning by unspecified drugs, medicaments and biological substances, intentional self-harm, sequela
- T50.903Poisoning by unspecified drugs, medicaments and biological substances, assault
- T50.903APoisoning by unspecified drugs, medicaments and biological substances, assault, initial encounter
- T50.903DPoisoning by unspecified drugs, medicaments and biological substances, assault, subsequent encounter
- T50.903SPoisoning by unspecified drugs, medicaments and biological substances, assault, sequela
- T50.904Poisoning by unspecified drugs, medicaments and biological substances, undetermined
- T50.904APoisoning by unspecified drugs, medicaments and biological substances, undetermined, initial encounter
- T50.904DPoisoning by unspecified drugs, medicaments and biological substances, undetermined, subsequent encounter
- T50.904SPoisoning by unspecified drugs, medicaments and biological substances, undetermined, sequela
- T50.905Adverse effect of unspecified drugs, medicaments and biological substances
- T50.905AAdverse effect of unspecified drugs, medicaments and biological substances, initial encounter
- T50.905DAdverse effect of unspecified drugs, medicaments and biological substances, subsequent encounter
- T50.905SAdverse effect of unspecified drugs, medicaments and biological substances, sequela
- T50.906Underdosing of unspecified drugs, medicaments and biological substances
- T50.906AUnderdosing of unspecified drugs, medicaments and biological substances, initial encounter
- T50.906DUnderdosing of unspecified drugs, medicaments and biological substances, subsequent encounter
- T50.906SUnderdosing of unspecified drugs, medicaments and biological substances, sequela
- T88.6XXAAnaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter
- T88.7XXAUnspecified adverse effect of drug or medicament, initial encounter
- Z91.120Patient's intentional underdosing of medication regimen due to financial hardship
- Z91.128Patient's intentional underdosing of medication regimen for other reason
- Z91.130Patient's unintentional underdosing of medication regimen due to age-related debility
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