Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Internal Codes
  • E87

    Other disorders of fluid, electrolyte and acid-base balance

  • E87.0

    Hyperosmolality and hypernatremia

  • E87.1

    Hypo-osmolality and hyponatremia

  • E87.2

    Acidosis

  • E87.20

    Acidosis, unspecified

  • E87.21

    Acute metabolic acidosis

  • E87.22

    Chronic metabolic acidosis

  • E87.29

    Other acidosis

  • E87.3

    Alkalosis

  • E87.4

    Mixed disorder of acid-base balance

  • E87.5

    Hyperkalemia

  • E87.6

    Hypokalemia

  • E87.7

    Fluid overload

  • E87.70

    Fluid overload, unspecified

  • E87.71

    Transfusion associated circulatory overload

  • E87.79

    Other fluid overload

  • E87.8

    Other disorders of electrolyte and fluid balance, not elsewhere classified

  • E88

    Other and unspecified metabolic disorders

  • E88.0

    Disorders of plasma-protein metabolism, not elsewhere classified

  • E88.01

    Alpha-1-antitrypsin deficiency

  • E88.02

    Plasminogen deficiency

  • E88.09

    Other disorders of plasma-protein metabolism, not elsewhere classified

  • E88.1

    Lipodystrophy, not elsewhere classified

  • E88.10

    Lipodystrophy, unspecified

  • E88.11

    Partial lipodystrophy

  • E88.12

    Generalized lipodystrophy

  • E88.13

    Localized lipodystrophy

  • E88.14

    HIV-associated lipodystrophy

  • E88.19

    Other lipodystrophy, not elsewhere classified

  • E88.2

    Lipomatosis, not elsewhere classified

  • E88.3

    Tumor lysis syndrome

  • E88.4

    Mitochondrial metabolism disorders

  • E88.40

    Mitochondrial metabolism disorder, unspecified

  • E88.41

    MELAS syndrome

  • E88.42

    MERRF syndrome

  • E88.43

    Disorders of mitochondrial tRNA synthetases

  • E88.49

    Other mitochondrial metabolism disorders

  • E88.8

    Other specified metabolic disorders

  • E88.81

    Metabolic syndrome and other insulin resistance

  • E88.810

    Metabolic syndrome

  • E88.811

    Insulin resistance syndrome, Type A

  • E88.818

    Other insulin resistance

  • E88.819

    Insulin resistance, unspecified

  • E88.82

    Obesity due to disruption of MC4R pathway

  • E88.89

    Other specified metabolic disorders

  • E88.9

    Metabolic disorder, unspecified

  • E88.A

    Wasting disease (syndrome) due to underlying condition

  • E89

    Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

  • E89.0

    Postprocedural hypothyroidism

  • E89.1

    Postprocedural hypoinsulinemia

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