Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Internal Codes
  • E87|

    Other disorders of fluid, electrolyte and acid-base balance

  • E87.0|

    Hyperosmolality and hypernatremia

  • E87.1|

    Hypo-osmolality and hyponatremia

  • E87.2|

    Acidosis

  • E87.20|

    Acidosis, unspecified

  • E87.21|

    Acute metabolic acidosis

  • E87.22|

    Chronic metabolic acidosis

  • E87.29|

    Other acidosis

  • E87.3|

    Alkalosis

  • E87.4|

    Mixed disorder of acid-base balance

  • E87.5|

    Hyperkalemia

  • E87.6|

    Hypokalemia

  • E87.7|

    Fluid overload

  • E87.70|

    Fluid overload, unspecified

  • E87.71|

    Transfusion associated circulatory overload

  • E87.79|

    Other fluid overload

  • E87.8|

    Other disorders of electrolyte and fluid balance, not elsewhere classified

  • E88|

    Other and unspecified metabolic disorders

  • E88.0|

    Disorders of plasma-protein metabolism, not elsewhere classified

  • E88.01|

    Alpha-1-antitrypsin deficiency

  • E88.02|

    Plasminogen deficiency

  • E88.09|

    Other disorders of plasma-protein metabolism, not elsewhere classified

  • E88.1|

    Lipodystrophy, not elsewhere classified

  • E88.10|

    Lipodystrophy, unspecified

  • E88.11|

    Partial lipodystrophy

  • E88.12|

    Generalized lipodystrophy

  • E88.13|

    Localized lipodystrophy

  • E88.14|

    HIV-associated lipodystrophy

  • E88.19|

    Other lipodystrophy, not elsewhere classified

  • E88.2|

    Lipomatosis, not elsewhere classified

  • E88.3|

    Tumor lysis syndrome

  • E88.4|

    Mitochondrial metabolism disorders

  • E88.40|

    Mitochondrial metabolism disorder, unspecified

  • E88.41|

    MELAS syndrome

  • E88.42|

    MERRF syndrome

  • E88.43|

    Disorders of mitochondrial tRNA synthetases

  • E88.49|

    Other mitochondrial metabolism disorders

  • E88.8|

    Other specified metabolic disorders

  • E88.81|

    Metabolic syndrome and other insulin resistance

  • E88.810|

    Metabolic syndrome

  • E88.811|

    Insulin resistance syndrome, Type A

  • E88.818|

    Other insulin resistance

  • E88.819|

    Insulin resistance, unspecified

  • E88.82|

    Obesity due to disruption of MC4R pathway

  • E88.89|

    Other specified metabolic disorders

  • E88.9|

    Metabolic disorder, unspecified

  • E88.A|

    Wasting disease (syndrome) due to underlying condition

  • E89|

    Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

  • E89.0|

    Postprocedural hypothyroidism

  • E89.1|

    Postprocedural hypoinsulinemia

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