E75Not billable, use a more specific code below

Disorders of sphingolipid metabolism and other lipid storage disorders

In Metabolic disorders (E70-E88), chapter 4: Endocrine, Nutritional and Metabolic Diseases

26 billable codes under E75: 14 are a CC; 2 map to HCC 49 (Specified Lysosomal Storage Disorders).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.

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Instructional notes

Excludes1: not coded here, use a different code

Also applies, from Metabolic disorders (E70-E88)

These notes sit on E70-E88 and apply to every code under it, including E75.

Excludes1: not coded here, use a different code

  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)

Excludes2: not included here, code separately if applicable

  • Ehlers-Danlos syndromes (Q79.6-)

Official coding guidelines

From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.

Covers diabetes mellitus coding, including type, insulin and drug use, pump malfunction and secondary diabetes, plus obesity and obesity class codes.

Read Section I.C.4 (page 39)

E75 MS-DRGs

As the principal diagnosis, the billable codes under E75 group to MS-DRG 056, 057, or 642 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.

Other codes that refer to E75

Notes on these codes point to E75.

  • G73.7 Code First: lipid storage disorders (E75.-)
  • H36 Code First: lipid storage disorders (E75.-)
  • R79 Excludes1: specific findings indicating disorder of lipid metabolism (E75.-)

About the condition

Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.

Genetic Brain Disorders

A genetic brain disorder is caused by a variation or a mutation in a gene. A variation is a different form of a gene. A mutation is a change in a gene. Genetic brain disorders affect the development and function of the brain.

Read more about genetic brain disorders on MedlinePlus

Code history

Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.