Chapter 3

D50–D89: Diseases of the Blood and Blood-Forming Organs

Diseases of the Blood and Blood-Forming Organs diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Internal Codes
  • D60.8

    Other acquired pure red cell aplasias

  • D60.9

    Acquired pure red cell aplasia, unspecified

  • D61.01

    Constitutional (pure) red blood cell aplasia

  • D61.02

    Shwachman-Diamond syndrome

  • D61.03

    Fanconi anemia

  • D61.09

    Other constitutional aplastic anemia

  • D61.1

    Drug-induced aplastic anemia

  • D61.2

    Aplastic anemia due to other external agents

  • D61.3

    Idiopathic aplastic anemia

  • D61.810

    Antineoplastic chemotherapy induced pancytopenia

  • D61.811

    Other drug-induced pancytopenia

  • D61.818

    Other pancytopenia

  • D61.82

    Myelophthisis

  • D61.89

    Other specified aplastic anemias and other bone marrow failure syndromes

  • D61.9

    Aplastic anemia, unspecified

  • D62

    Acute posthemorrhagic anemia

  • D63.0

    Anemia in neoplastic disease

  • D63.1

    Anemia in chronic kidney disease

  • D63.8

    Anemia in other chronic diseases classified elsewhere

  • D64.0

    Hereditary sideroblastic anemia

  • D64.1

    Secondary sideroblastic anemia due to disease

  • D64.2

    Secondary sideroblastic anemia due to drugs and toxins

  • D64.3

    Other sideroblastic anemias

  • D64.4

    Congenital dyserythropoietic anemia

  • D64.81

    Anemia due to antineoplastic chemotherapy

  • D64.89

    Other specified anemias

  • D64.9

    Anemia, unspecified

  • D65

    Disseminated intravascular coagulation [defibrination syndrome]

  • D66

    Hereditary factor VIII deficiency

  • D67

    Hereditary factor IX deficiency

  • D68.00

    Von Willebrand disease, unspecified

  • D68.01

    Von Willebrand disease, type 1

  • D68.020

    Von Willebrand disease, type 2A

  • D68.021

    Von Willebrand disease, type 2B

  • D68.022

    Von Willebrand disease, type 2M

  • D68.023

    Von Willebrand disease, type 2N

  • D68.029

    Von Willebrand disease, type 2, unspecified

  • D68.03

    Von Willebrand disease, type 3

  • D68.04

    Acquired von Willebrand disease

  • D68.09

    Other von Willebrand disease

  • D68.1

    Hereditary factor XI deficiency

  • D68.2

    Hereditary deficiency of other clotting factors

  • D68.311

    Acquired hemophilia

  • D68.312

    Antiphospholipid antibody with hemorrhagic disorder

  • D68.318

    Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors

  • D68.32

    Hemorrhagic disorder due to extrinsic circulating anticoagulants

  • D68.4

    Acquired coagulation factor deficiency

  • D68.51

    Activated protein C resistance

  • D68.52

    Prothrombin gene mutation

  • D68.59

    Other primary thrombophilia

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