Hereditary factor VIII deficiency
In Coagulation defects, purpura and other hemorrhagic conditions (D65-D69), chapter 3: Diseases of the Blood and Blood-Forming Organs
- D66 is billable and valid on claims for FY 2027. If the record has more detail, check the other codes under D65-D69 below.
- As a secondary diagnosis it is an MCC (major complication), which can raise the MS-DRG payment. It doesn't count when the principal diagnosis is one of 51 closely related codes.
- Counts toward HCC 111 (Hemophilia, Male) in the Medicare Advantage risk model (CMS-HCC V28).
- AHRQ's Chronic Condition Indicator classes it as chronic: expected to last 12 months or longer and to limit daily life or need ongoing care.
- 62 US deaths in 2024 had an underlying cause in category D66, per the National Vital Statistics System on CDC WONDER. Death records use WHO ICD-10, so the count is for the whole category.
Also indexed as: Arthritis, due to or associated with, hemophilia; Arthritis, in, hemophilia NEC; Arthropathy, hemophilic NEC; Arthropathy, in, hemophilia NEC; Deficiency, anti-hemophilic, factor; Deficiency, anti-hemophilic, globulin NEC; Deficiency, factor, VIII; Disease, bleeder's; Hemophilia; Hemophilia, A; Subhemophilia
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Instructional notes
Includes: conditions that are coded here
- Classical hemophilia
- Deficiency factor VIII (with functional defect)
- Hemophilia NOS
- Hemophilia A
Excludes1: not coded here, use a different code
- factor VIII deficiency with vascular defect (D68.0-)
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
There are no chapter-specific rules for Chapter 3 yet, so the general rules in Section I.B apply.
Other codes under D65-D69
Coagulation defects, purpura and other hemorrhagic conditions (D65-D69)
- D65Disseminated intravascular coagulation [defibrination syndrome]
- D66Hereditary factor VIII deficiency(this code)
- D67Hereditary factor IX deficiency
- D68Other coagulation defects
- D69Purpura and other hemorrhagic conditions
D66 MS-DRG
As the principal diagnosis, D66 groups to MS-DRG 813 (v44.0).
Related conditions
Grouped by AHRQ's Clinical Classifications Software Refined (CCSR), which sorts every diagnosis code into clinically meaningful categories.
D66 is in Coagulation and hemorrhagic disorders (BLD006, its default category), with 49 codes. Others in it:
- D47.3 Essential (hemorrhagic) thrombocythemia
- D65 Disseminated intravascular coagulation [defibrination syndrome]
- D67 Hereditary factor IX deficiency
- D68.00 Von Willebrand disease, unspecified
- D68.01 Von Willebrand disease, type 1
- D68.020 Von Willebrand disease, type 2A
- D68.021 Von Willebrand disease, type 2B
- D68.022 Von Willebrand disease, type 2M
Medicare coverage articles listing D66
This Medicare billing and coding article lists D66 as a diagnosis that supports medical necessity for the services they cover. From the CMS Medicare Coverage Database; check your own contractor's article before billing.
Other codes that refer to D66
Notes on these codes point to D66.
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Hemophilia
Hemophilia is a rare bleeding disorder in which the blood does not clot properly. This can lead to problems with bleeding too much after an injury or surgery. You can also have sudden bleeding inside your body, such as in your joints, muscles, and organs.
Read more about hemophilia on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
ICD-9-CM equivalent
Legacy crosswalk from the CMS General Equivalence Mappings (last updated 2018).
- 286.0 Congenital factor VIII disorder