New ICD-10-CM Codes for FY2022

CMS added 159 diagnosis codes in the FY2022 update, effective October 1, 2021.

Chapter 1: A00–B99 (Certain Infectious and Parasitic Diseases)1 code

A79.82Anaplasmosis [A. phagocytophilum]Previously A77.49

Chapter 2: C00–D49 (Neoplasms)3 codes

C56.3Malignant neoplasm of bilateral ovariesPreviously C56.1 and C56.2
C79.63Secondary malignant neoplasm of bilateral ovariesPreviously C79.61 and C79.62
C84.7AAnaplastic large cell lymphoma, ALK-negative, breastPreviously C84.79

Chapter 3: D50–D89 (Diseases of the Blood and Blood-Forming Organs)5 codes

D55.21Anemia due to pyruvate kinase deficiencyPreviously D55.2
D55.29Anemia due to other disorders of glycolytic enzymesPreviously D55.2
D75.838Other thrombocytosisPreviously D75.89
D75.839Thrombocytosis, unspecifiedPreviously D75.89
D89.44Hereditary alpha tryptasemiaPreviously D89.49

Chapter 4: E00–E89 (Endocrine, Nutritional and Metabolic Diseases)1 code

E75.244Niemann-Pick disease type A/BPreviously E75.240, E75.241, E75.248, E75.249

Chapter 5: F01–F99 (Mental, Behavioral and Neurodevelopmental Disorders)3 codes

F32.ADepression, unspecifiedPreviously F32.9
F78.A1SYNGAP1-related intellectual disabilityPreviously F78
F78.A9Other genetic related intellectual disabilityPreviously F78

Chapter 6: G00–G99 (Diseases of the Nervous System)10 codes

G04.82Acute flaccid myelitisPreviously G04.89
G44.86Cervicogenic headachePreviously G44.89
G92.00Immune effector cell-associated neurotoxicity syndrome, grade unspecifiedPreviously G92
G92.01Immune effector cell-associated neurotoxicity syndrome, grade 1Previously G92
G92.02Immune effector cell-associated neurotoxicity syndrome, grade 2Previously G92
G92.03Immune effector cell-associated neurotoxicity syndrome, grade 3Previously G92
G92.04Immune effector cell-associated neurotoxicity syndrome, grade 4Previously G92
G92.05Immune effector cell-associated neurotoxicity syndrome, grade 5Previously G92
G92.8Other toxic encephalopathyPreviously G92
G92.9Unspecified toxic encephalopathyPreviously G92

Chapter 9: I00–I99 (Diseases of the Circulatory System)1 code

I5ANon-ischemic myocardial injury (non-traumatic)Previously I21.A9

Chapter 11: K00–K95 (Diseases of the Digestive System)13 codes

K22.81Esophageal polypPreviously K22.8
K22.82Esophagogastric junction polypPreviously K22.8
K22.89Other specified disease of esophagusPreviously K22.8
K31.A0Gastric intestinal metaplasia, unspecifiedPreviously K31.89
K31.A11Gastric intestinal metaplasia without dysplasia, involving the antrumPreviously K31.89
K31.A12Gastric intestinal metaplasia without dysplasia, involving the body (corpus)Previously K31.89
K31.A13Gastric intestinal metaplasia without dysplasia, involving the fundusPreviously K31.89
K31.A14Gastric intestinal metaplasia without dysplasia, involving the cardiaPreviously K31.89
K31.A15Gastric intestinal metaplasia without dysplasia, involving multiple sitesPreviously K31.89
K31.A19Gastric intestinal metaplasia without dysplasia, unspecified sitePreviously K31.89
K31.A21Gastric intestinal metaplasia with low grade dysplasiaPreviously K31.89
K31.A22Gastric intestinal metaplasia with high grade dysplasiaPreviously K31.89
K31.A29Gastric intestinal metaplasia with dysplasia, unspecifiedPreviously K31.89

Chapter 12: L00–L99 (Diseases of the Skin and Subcutaneous Tissue)8 codes

L24.A0Irritant contact dermatitis due to friction or contact with body fluids, unspecifiedPreviously L24.89
L24.A1Irritant contact dermatitis due to salivaPreviously L24.89
L24.A2Irritant contact dermatitis due to fecal, urinary or dual incontinencePreviously L24.89
L24.A9Irritant contact dermatitis due friction or contact with other specified body fluidsPreviously L24.89
L24.B0Irritant contact dermatitis related to unspecified stoma or fistulaPreviously L24.89
L24.B1Irritant contact dermatitis related to digestive stoma or fistulaPreviously L24.89
L24.B2Irritant contact dermatitis related to respiratory stoma or fistulaPreviously L24.89
L24.B3Irritant contact dermatitis related to fecal or urinary stoma or fistulaPreviously L24.89

Chapter 13: M00–M99 (Diseases of the Musculoskeletal System and Connective Tissue)23 codes

M31.10Thrombotic microangiopathy, unspecifiedPreviously M31.1
M31.11Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]Previously M31.1
M31.19Other thrombotic microangiopathyPreviously M31.1
M35.05Sjogren syndrome with inflammatory arthritisPreviously M35.09
M35.06Sjogren syndrome with peripheral nervous system involvementPreviously M35.09
M35.07Sjogren syndrome with central nervous system involvementPreviously M35.09
M35.08Sjogren syndrome with gastrointestinal involvementPreviously M35.09
M35.0ASjogren syndrome with glomerular diseasePreviously M35.09
M35.0BSjogren syndrome with vasculitisPreviously M35.09
M35.0CSjogren syndrome with dental involvementPreviously M35.09
M45.A0Non-radiographic axial spondyloarthritis of unspecified sites in spinePreviously M45.9
M45.A1Non-radiographic axial spondyloarthritis of occipito-atlanto-axial regionPreviously M45.1
M45.A2Non-radiographic axial spondyloarthritis of cervical regionPreviously M45.2
M45.A3Non-radiographic axial spondyloarthritis of cervicothoracic regionPreviously M45.3
M45.A4Non-radiographic axial spondyloarthritis of thoracic regionPreviously M45.4
M45.A5Non-radiographic axial spondyloarthritis of thoracolumbar regionPreviously M45.5
M45.A6Non-radiographic axial spondyloarthritis of lumbar regionPreviously M45.6
M45.A7Non-radiographic axial spondyloarthritis of lumbosacral regionPreviously M45.7
M45.A8Non-radiographic axial spondyloarthritis of sacral and sacrococcygeal regionPreviously M45.8
M45.ABNon-radiographic axial spondyloarthritis of multiple sites in spinePreviously M45.0
M54.50Low back pain, unspecifiedPreviously M54.5
M54.51Vertebrogenic low back painPreviously M54.5
M54.59Other low back painPreviously M54.5

Chapter 16: P00–P96 (Certain Conditions Originating in the Perinatal Period)9 codes

P00.82Newborn affected by (positive) maternal group B streptococcus (GBS) colonizationPreviously P00.89
P09.1Abnormal findings on neonatal screening for inborn errors of metabolismPreviously P09
P09.2Abnormal findings on neonatal screening for congenital endocrine diseasePreviously P09
P09.3Abnormal findings on neonatal screening for congenital hematologic disordersPreviously P09
P09.4Abnormal findings on neonatal screening for cystic fibrosisPreviously P09
P09.5Abnormal findings on neonatal screening for critical congenital heart diseasePreviously P09
P09.6Abnormal findings on neonatal hearing screeningPreviously P09
P09.8Other abnormal findings on neonatal screeningPreviously P09
P09.9Abnormal findings on neonatal screening, unspecifiedPreviously P09

Chapter 18: R00–R99 (Symptoms, Signs and Abnormal Clinical and Laboratory Findings)14 codes

R05.1Acute coughPreviously R05
R05.2Subacute coughPreviously R05
R05.3Chronic coughPreviously R05
R05.4Cough syncopePreviously R05
R05.8Other specified coughPreviously R05
R05.9Cough, unspecifiedPreviously R05
R35.81Nocturnal polyuriaPreviously R35.8
R35.89Other polyuriaPreviously R35.8
R45.88Nonsuicidal self-harmPreviously R45.89
R63.30Feeding difficulties, unspecifiedPreviously R63.3
R63.31Pediatric feeding disorder, acutePreviously R63.3
R63.32Pediatric feeding disorder, chronicPreviously R63.3
R63.39Other feeding difficultiesPreviously R63.3
R79.83Abnormal findings of blood amino-acid levelPreviously R79.89

Chapter 19: S00–T88 (Injury, Poisoning and Certain Other Consequences of External Causes)45 codes

S06.A0XATraumatic brain compression without herniation, initial encounterPreviously S06.890A-S06.899A
S06.A0XDTraumatic brain compression without herniation, subsequent encounterPreviously S06.890D-S06.899D
S06.A0XSTraumatic brain compression without herniation, sequelaPreviously S06.890D-S06.899S
S06.A1XATraumatic brain compression with herniation, initial encounterPreviously S06.890A-S06.899A
S06.A1XDTraumatic brain compression with herniation, subsequent encounterPreviously S06.890D-S06.899D
S06.A1XSTraumatic brain compression with herniation, sequelaPreviously S06.890D-S06.899S
T40.711APoisoning by cannabis, accidental (unintentional), initial encounterPreviously T40.7X1A
T40.711DPoisoning by cannabis, accidental (unintentional), subsequent encounterPreviously T40.7X1D
T40.711SPoisoning by cannabis, accidental (unintentional), sequelaPreviously T40.7X1S
T40.712APoisoning by cannabis, intentional self-harm, initial encounterPreviously T40.7X2A
T40.712DPoisoning by cannabis, intentional self-harm, subsequent encounterPreviously T40.7X2D
T40.712SPoisoning by cannabis, intentional self-harm, sequelaPreviously T40.7X2S
T40.713APoisoning by cannabis, assault, initial encounterPreviously T40.7X3A
T40.713DPoisoning by cannabis, assault, subsequent encounterPreviously T40.7X3D
T40.713SPoisoning by cannabis, assault, sequelaPreviously T40.7X3S
T40.714APoisoning by cannabis, undetermined, initial encounterPreviously T40.7X4A
T40.714DPoisoning by cannabis, undetermined, subsequent encounterPreviously T40.7X4D
T40.714SPoisoning by cannabis, undetermined, sequelaPreviously T40.7X4S
T40.715AAdverse effect of cannabis, initial encounterPreviously T40.7X5A
T40.715DAdverse effect of cannabis, subsequent encounterPreviously T40.7X5D
T40.715SAdverse effect of cannabis, sequelaPreviously T40.7X5S
T40.716AUnderdosing of cannabis, initial encounterPreviously T40.7X6A
T40.716DUnderdosing of cannabis, subsequent encounterPreviously T40.7X6D
T40.716SUnderdosing of cannabis, sequelaPreviously T40.7X6S
T40.721APoisoning by synthetic cannabinoids, accidental (unintentional), initial encounterPreviously T40.7X1A
T40.721DPoisoning by synthetic cannabinoids, accidental (unintentional), subsequent encounterPreviously T40.7X1D
T40.721SPoisoning by synthetic cannabinoids, accidental (unintentional), sequelaPreviously T40.7X1S
T40.722APoisoning by synthetic cannabinoids, intentional self-harm, initial encounterPreviously T40.7X2A
T40.722DPoisoning by synthetic cannabinoids, intentional self-harm, subsequent encounterPreviously T40.7X2D
T40.722SPoisoning by synthetic cannabinoids, intentional self-harm, sequelaPreviously T40.7X2S
T40.723APoisoning by synthetic cannabinoids, assault, initial encounterPreviously T40.7X3A
T40.723DPoisoning by synthetic cannabinoids, assault, subsequent encounterPreviously T40.7X3D
T40.723SPoisoning by synthetic cannabinoids, assault, sequelaPreviously T40.7X3S
T40.724APoisoning by synthetic cannabinoids, undetermined, initial encounterPreviously T40.7X4A
T40.724DPoisoning by synthetic cannabinoids, undetermined, subsequent encounterPreviously T40.7X4D
T40.724SPoisoning by synthetic cannabinoids, undetermined, sequelaPreviously T40.7X4S
T40.725AAdverse effect of synthetic cannabinoids, initial encounterPreviously T40.7X5A
T40.725DAdverse effect of synthetic cannabinoids, subsequent encounterPreviously T40.7X5D
T40.725SAdverse effect of synthetic cannabinoids, sequelaPreviously T40.7X5S
T40.726AUnderdosing of synthetic cannabinoids, initial encounterPreviously T40.7X6A
T40.726DUnderdosing of synthetic cannabinoids, subsequent encounterPreviously T40.7X6D
T40.726SUnderdosing of synthetic cannabinoids, sequelaPreviously T40.7X6S
T80.82XAComplication of immune effector cellular therapy, initial encounterPreviously T80.89XA
T80.82XDComplication of immune effector cellular therapy, subsequent encounterPreviously T80.89XD
T80.82XSComplication of immune effector cellular therapy, sequelaPreviously T80.89XS

Chapter 20: V00–Y99 (External Causes of Morbidity)3 codes

Y35.899ALegal intervention involving other specified means, unspecified person injured, initial encounterPreviously Y35.99XA
Y35.899DLegal intervention involving other specified means, unspecified person injured, subsequent encounterPreviously Y35.99XD
Y35.899SLegal intervention involving other specified means, unspecified person injured, sequelaPreviously Y35.99XS

Chapter 21: Z00–Z99 (Factors Influencing Health Status and Contact with Health Services)19 codes

Z55.5Less than a high school diplomaPreviously Z55.8
Z58.6Inadequate drinking-water supplyPreviously Z59.4
Z59.00Homelessness unspecifiedPreviously Z59.0
Z59.01Sheltered homelessnessPreviously Z59.0
Z59.02Unsheltered homelessnessPreviously Z59.0
Z59.41Food insecurityPreviously Z59.4
Z59.48Other specified lack of adequate foodPreviously Z59.4
Z59.811Housing instability, housed, with risk of homelessnessPreviously Z59.8
Z59.812Housing instability, housed, homelessness in past 12 monthsPreviously Z59.8
Z59.819Housing instability, housed unspecifiedPreviously Z59.8
Z59.89Other problems related to housing and economic circumstancesPreviously Z59.8
Z71.85Encounter for immunization safety counselingPreviously Z71.89
Z91.014Allergy to mammalian meatsPreviously Z91.018
Z91.51Personal history of suicidal behaviorPreviously Z91.5
Z91.52Personal history of nonsuicidal self-harmPreviously Z91.5
Z92.850Personal history of Chimeric Antigen Receptor T-cell therapyPreviously Z92.89
Z92.858Personal history of other cellular therapyPreviously Z92.89
Z92.859Personal history of cellular therapy, unspecifiedPreviously Z92.89
Z92.86Personal history of gene therapyPreviously Z92.89

Chapter 22: U00–U85 (Codes for Special Purposes)1 code

U09.9Post COVID-19 condition, unspecifiedPreviously B94.9