New ICD-10-CM Codes for FY2025

CMS added 252 diagnosis codes in the FY2025 update, effective October 1, 2024.

Chapter 2: C00–D49 (Neoplasms)63 codes

C81.0ANodular lymphocyte predominant Hodgkin lymphoma, in remissionPreviously Z85.71

C81.1ANodular sclerosis Hodgkin lymphoma, in remissionPreviously Z85.71

C81.2AMixed cellularity Hodgkin lymphoma, in remissionPreviously Z85.71

C81.3ALymphocyte depleted Hodgkin lymphoma, in remissionPreviously Z85.71

C81.4ALymphocyte-rich Hodgkin lymphoma, in remissionPreviously Z85.71

C81.7AOther Hodgkin lymphoma, in remissionPreviously Z85.71

C81.9AHodgkin lymphoma, unspecified, in remissionPreviously Z85.71

C82.0AFollicular lymphoma grade I, in remissionPreviously Z85.72

C82.1AFollicular lymphoma grade II, in remissionPreviously Z85.72

C82.2AFollicular lymphoma grade III, unspecified, in remissionPreviously Z85.72

C82.3AFollicular lymphoma grade IIIa, in remissionPreviously Z85.72

C82.4AFollicular lymphoma grade IIIb, in remissionPreviously Z85.72

C82.5ADiffuse follicle center lymphoma, in remissionPreviously Z85.72

C82.6ACutaneous follicle center lymphoma, in remissionPreviously Z85.72

C82.8AOther types of follicular lymphoma, in remissionPreviously Z85.72

C82.9AFollicular lymphoma, unspecified, in remissionPreviously Z85.72

C83.0ASmall cell B-cell lymphoma, in remissionPreviously Z85.72

C83.1AMantle cell lymphoma, in remissionPreviously Z85.72

C83.390Primary central nervous system lymphomaPreviously Z85.72

C83.398Diffuse large B-cell lymphoma of other extranodal and solid organ sitesPreviously Z85.72

C83.3ADiffuse large B-cell lymphoma, in remissionPreviously Z85.72

C83.5ALymphoblastic (diffuse) lymphoma, in remissionPreviously Z85.72

C83.7ABurkitt lymphoma, in remissionPreviously Z85.72

C83.8AOther non-follicular lymphoma, in remissionPreviously Z85.72

C83.9ANon-follicular (diffuse) lymphoma, unspecified, in remissionPreviously Z85.72

C84.0AMycosis fungoides, in remissionPreviously Z85.72

C84.1ASezary disease, in remissionPreviously Z85.72

C84.4APeripheral T-cell lymphoma, not elsewhere classified, in remissionPreviously Z85.72

C84.6AAnaplastic large cell lymphoma, ALK-positive, in remissionPreviously Z85.72

C84.7BAnaplastic large cell lymphoma, ALK-negative, in remissionPreviously Z85.72

C84.9AMature T/NK-cell lymphomas, unspecified, in remissionPreviously Z85.72

C84.AACutaneous T-cell lymphoma, unspecified, in remissionPreviously Z85.72

C84.ZAOther mature T/NK-cell lymphomas, in remissionPreviously Z85.72

C85.1AUnspecified B-cell lymphoma, in remissionPreviously Z85.72

C85.2AMediastinal (thymic) large B-cell lymphoma, in remissionPreviously Z85.72

C85.8AOther specified types of non-Hodgkin lymphoma, in remissionPreviously Z85.72

C85.9ANon-Hodgkin lymphoma, unspecified, in remissionPreviously Z85.72

C86.00Extranodal NK/T-cell lymphoma, nasal type not having achieved remissionPreviously C86.0

C86.01Extranodal NK/T-cell lymphoma, nasal type, in remissionPreviously Z85.72

C86.10Hepatosplenic T-cell lymphoma not having achieved remissionPreviously C86.1

C86.11Hepatosplenic T-cell lymphoma, in remissionPreviously Z85.72

C86.20Enteropathy-type (intestinal) T-cell lymphoma not having achieved remissionPreviously C86.2

C86.21Enteropathy-type (intestinal) T-cell lymphoma, in remissionPreviously Z85.72

C86.30Subcutaneous panniculitis-like T-cell lymphoma not having achieved remissionPreviously C86.3

C86.31Subcutaneous panniculitis-like T-cell lymphoma, in remissionPreviously Z85.72

C86.40Blastic NK-cell lymphoma not having achieved remissionPreviously C86.4

C86.41Blastic NK-cell lymphoma, in remissionPreviously Z85.72

C86.50Angioimmunoblastic T-cell lymphoma not having achieved remissionPreviously C86.5

C86.51Angioimmunoblastic T-cell lymphoma, in remissionPreviously Z85.72

C86.60Primary cutaneous CD30-positive T-cell proliferations not having achieved remissionPreviously C86.6

C86.61Primary cutaneous CD30-positive T-cell proliferations, in remissionPreviously Z85.72

C88.00Waldenstrom macroglobulinemia not having achieved remissionPreviously C88.0

C88.01Waldenstrom macroglobulinemia, in remissionPreviously Z85.79

C88.20Heavy chain disease not having achieved remissionPreviously C88.2

C88.21Heavy chain disease, in remissionPreviously Z85.79

C88.30Immunoproliferative small intestinal disease not having achieved remissionPreviously C88.3

C88.31Immunoproliferative small intestinal disease, in remissionPreviously Z85.79

C88.40Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] not having achieved remissionPreviously C88.4

C88.41Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma], in remissionPreviously Z85.79

C88.80Other malignant immunoproliferative diseases not having achieved remissionPreviously C88.8

C88.81Other malignant immunoproliferative diseases, in remissionPreviously Z85.79

C88.90Malignant immunoproliferative disease, unspecified not having achieved remissionPreviously C88.9

C88.91Malignant immunoproliferative disease, unspecified, in remissionPreviously Z85.79

Chapter 3: D50–D89 (Diseases of the Blood and Blood-Forming Organs)1 code

D61.03Fanconi anemiaPreviously D61.09

Chapter 4: E00–E89 (Endocrine, Nutritional and Metabolic Diseases)16 codes

E10.A0Type 1 diabetes mellitus, presymptomatic, unspecifiedPreviously R73.03

E10.A1Type 1 diabetes mellitus, presymptomatic, Stage 1Previously R73.03

E10.A2Type 1 diabetes mellitus, presymptomatic, Stage 2Previously R73.03

E16.A1Hypoglycemia level 1Previously E16.2

E16.A2Hypoglycemia level 2Previously E16.2

E16.A3Hypoglycemia level 3Previously E16.2

E34.00Carcinoid syndrome, unspecifiedPreviously E34.0

E34.01Carcinoid heart syndromePreviously E34.0

E34.09Other carcinoid syndromePreviously E34.0

E66.811Obesity, class 1Previously E66.8

E66.812Obesity, class 2Previously E66.8

E66.813Obesity, class 3Previously E66.01, E66.8

E66.89Other obesity not elsewhere classifiedPreviously E66.8

E74.820SLC13A5 Citrate Transporter DisorderPreviously E74.89

E74.829Other disorders of citrate metabolismPreviously E74.89

E88.82Obesity due to disruption of MC4R pathwayPreviously E88.89

Chapter 5: F01–F99 (Mental, Behavioral and Neurodevelopmental Disorders)26 codes

F50.010Anorexia nervosa, restricting type, mildPreviously F50.01

F50.011Anorexia nervosa, restricting type, moderatePreviously F50.01

F50.012Anorexia nervosa, restricting type, severePreviously F50.01

F50.013Anorexia nervosa, restricting type, extremePreviously F50.01

F50.014Anorexia nervosa, restricting type, in remissionPreviously F50.01

F50.019Anorexia nervosa, restricting type, unspecifiedPreviously F50.01

F50.020Anorexia nervosa, binge eating/purging type, mildPreviously F50.02

F50.021Anorexia nervosa, binge eating/purging type, moderatePreviously F50.02

F50.022Anorexia nervosa, binge eating/purging type, severePreviously F50.02

F50.023Anorexia nervosa, binge eating/purging type, extremePreviously F50.02

F50.024Anorexia nervosa, binge eating/purging type, in remissionPreviously F50.02

F50.029Anorexia nervosa, binge eating/purging type, unspecifiedPreviously F50.02

F50.20Bulimia nervosa, unspecifiedPreviously F50.2

F50.21Bulimia nervosa, mildPreviously F50.2

F50.22Bulimia nervosa, moderatePreviously F50.2

F50.23Bulimia nervosa, severePreviously F50.2

F50.24Bulimia nervosa, extremePreviously F50.2

F50.25Bulimia nervosa, in remissionPreviously F50.2

F50.810Binge eating disorder, mildPreviously F50.81

F50.811Binge eating disorder, moderatePreviously F50.81

F50.812Binge eating disorder, severePreviously F50.81

F50.813Binge eating disorder, extremePreviously F50.81

F50.814Binge eating disorder, in remissionPreviously F50.81

F50.819Binge eating disorder, unspecifiedPreviously F50.81

F50.83Pica in adultsPreviously F50.89

F50.84Rumination disorder in adultsPreviously F50.89

Chapter 6: G00–G99 (Diseases of the Nervous System)7 codes

G40.841KCNQ2-related epilepsy, not intractable, with status epilepticusPreviously G40.89

G40.842KCNQ2-related epilepsy, not intractable, without status epilepticusPreviously G40.89

G40.843KCNQ2-related epilepsy, intractable, with status epilepticusPreviously G40.89

G40.844KCNQ2-related epilepsy, intractable, without status epilepticusPreviously G40.89

G90.81Serotonin syndromePreviously G90.8

G90.89Other disorders of autonomic nervous systemPreviously G90.8

G93.45Developmental and epileptic encephalopathyPreviously G93.49

Chapter 9: I00–I99 (Diseases of the Circulatory System)4 codes

I26.03Cement embolism of pulmonary artery with acute cor pulmonalePreviously I26.09

I26.04Fat embolism of pulmonary artery with acute cor pulmonalePreviously I26.09

I26.95Cement embolism of pulmonary artery without acute cor pulmonalePreviously I26.99

I26.96Fat embolism of pulmonary artery without acute cor pulmonalePreviously I26.99

Chapter 10: J00–J99 (Diseases of the Respiratory System)7 codes

J34.8200Internal nasal valve collapse, unspecifiedPreviously J34.89

J34.8201Internal nasal valve collapse, staticPreviously J34.89

J34.8202Internal nasal valve collapse, dynamicPreviously J34.89

J34.8210External nasal valve collapse, unspecifiedPreviously J34.89

J34.8211External nasal valve collapse, staticPreviously J34.89

J34.8212External nasal valve collapse, dynamicPreviously J34.89

J34.829Nasal valve collapse, unspecifiedPreviously J34.89

Chapter 11: K00–K95 (Diseases of the Digestive System)27 codes

K60.30Anal fistula, unspecifiedPreviously K60.3

K60.311Anal fistula, simple, initialPreviously K60.3

K60.312Anal fistula, simple, persistentPreviously K60.3

K60.313Anal fistula, simple, recurrentPreviously K60.3

K60.319Anal fistula, simple, unspecifiedPreviously K60.3

K60.321Anal fistula, complex, initialPreviously K60.3

K60.322Anal fistula, complex, persistentPreviously K60.3

K60.323Anal fistula, complex, recurrentPreviously K60.3

K60.329Anal fistula, complex, unspecifiedPreviously K60.3

K60.40Rectal fistula, unspecifiedPreviously K60.4

K60.411Rectal fistula, simple, initialPreviously K60.4

K60.412Rectal fistula, simple, persistentPreviously K60.4

K60.413Rectal fistula, simple, recurrentPreviously K60.4

K60.419Rectal fistula, simple, unspecifiedPreviously K60.4

K60.421Rectal fistula, complex, initialPreviously K60.4

K60.422Rectal fistula, complex, persistentPreviously K60.4

K60.423Rectal fistula, complex, recurrentPreviously K60.4

K60.429Rectal fistula, complex, unspecifiedPreviously K60.4

K60.50Anorectal fistula, unspecifiedPreviously K60.5

K60.511Anorectal fistula, simple, initialPreviously K60.5

K60.512Anorectal fistula, simple, persistentPreviously K60.5

K60.513Anorectal fistula, simple, recurrentPreviously K60.5

K60.519Anorectal fistula, simple, unspecifiedPreviously K60.5

K60.521Anorectal fistula, complex, initialPreviously K60.5

K60.522Anorectal fistula, complex, persistentPreviously K60.5

K60.523Anorectal fistula, complex, recurrentPreviously K60.5

K60.529Anorectal fistula, complex, unspecifiedPreviously K60.5

Chapter 12: L00–L99 (Diseases of the Skin and Subcutaneous Tissue)8 codes

L29.81Cholestatic pruritusPreviously L29.8

L29.89Other pruritusPreviously L29.8

L66.10Lichen planopilaris, unspecifiedPreviously L66.1

L66.11Classic lichen planopilarisPreviously L66.1

L66.12Frontal fibrosing alopeciaPreviously L66.1

L66.19Other lichen planopilarisPreviously L66.1

L66.81Central centrifugal cicatricial alopeciaPreviously L66.8

L66.89Other cicatricial alopeciaPreviously L66.8

Chapter 13: M00–M99 (Diseases of the Musculoskeletal System and Connective Tissue)33 codes

M51.360Other intervertebral disc degeneration, lumbar region with discogenic back pain onlyPreviously M51.36

M51.361Other intervertebral disc degeneration, lumbar region with lower extremity pain onlyPreviously M51.36

M51.362Other intervertebral disc degeneration, lumbar region with discogenic back pain and lower extremity painPreviously M51.36

M51.369Other intervertebral disc degeneration, lumbar region without mention of lumbar back pain or lower extremity painPreviously M51.36

M51.370Other intervertebral disc degeneration, lumbosacral region with discogenic back pain onlyPreviously M51.37

M51.371Other intervertebral disc degeneration, lumbosacral region with lower extremity pain onlyPreviously M51.37

M51.372Other intervertebral disc degeneration, lumbosacral region with discogenic back pain and lower extremity painPreviously M51.37

M51.379Other intervertebral disc degeneration, lumbosacral region without mention of lumbar back pain or lower extremity painPreviously M51.37

M62.85Dysfunction of the multifidus muscles, lumbar regionPreviously M62.89

M65.90Unspecified synovitis and tenosynovitis, unspecified sitePreviously M65.9

M65.911Unspecified synovitis and tenosynovitis, right shoulderPreviously M65.9

M65.912Unspecified synovitis and tenosynovitis, left shoulderPreviously M65.9

M65.919Unspecified synovitis and tenosynovitis, unspecified shoulderPreviously M65.9

M65.921Unspecified synovitis and tenosynovitis, right upper armPreviously M65.9

M65.922Unspecified synovitis and tenosynovitis, left upper armPreviously M65.9

M65.929Unspecified synovitis and tenosynovitis, unspecified upper armPreviously M65.9

M65.931Unspecified synovitis and tenosynovitis, right forearmPreviously M65.9

M65.932Unspecified synovitis and tenosynovitis, left forearmPreviously M65.9

M65.939Unspecified synovitis and tenosynovitis, unspecified forearmPreviously M65.9

M65.941Unspecified synovitis and tenosynovitis, right handPreviously M65.9

M65.942Unspecified synovitis and tenosynovitis, left handPreviously M65.9

M65.949Unspecified synovitis and tenosynovitis, unspecified handPreviously M65.9

M65.951Unspecified synovitis and tenosynovitis, right thighPreviously M65.9

M65.952Unspecified synovitis and tenosynovitis, left thighPreviously M65.9

M65.959Unspecified synovitis and tenosynovitis, unspecified thighPreviously M65.9

M65.961Unspecified synovitis and tenosynovitis, right lower legPreviously M65.9

M65.962Unspecified synovitis and tenosynovitis, left lower legPreviously M65.9

M65.969Unspecified synovitis and tenosynovitis, unspecified lower legPreviously M65.9

M65.971Unspecified synovitis and tenosynovitis, right ankle and footPreviously M65.9

M65.972Unspecified synovitis and tenosynovitis, left ankle and footPreviously M65.9

M65.979Unspecified synovitis and tenosynovitis, unspecified ankle and footPreviously M65.9

M65.98Unspecified synovitis and tenosynovitis, other sitePreviously M65.9

M65.99Unspecified synovitis and tenosynovitis, multiple sitesPreviously M65.9

Chapter 17: Q00–Q99 (Congenital Malformations, Deformations and Chromosomal Abnormalities)4 codes

Q23.81Bicuspid aortic valvePreviously Q23.8

Q23.82Congenital mitral valve cleft leafletPreviously Q23.8

Q23.88Other congenital malformations of aortic and mitral valvesPreviously Q23.8

Q87.86Kleefstra syndromePreviously Q87.89

Chapter 18: R00–R99 (Symptoms, Signs and Abnormal Clinical and Laboratory Findings)1 code

R41.85AnosognosiaPreviously R41.89

Chapter 19: S00–T88 (Injury, Poisoning and Certain Other Consequences of External Causes)30 codes

T45.AX1APoisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional), initial encounterPreviously T45.1X1A

T45.AX1DPoisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional), subsequent encounterPreviously T45.1X1D

T45.AX1SPoisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional), sequelaPreviously T45.1X1S

T45.AX2APoisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm, initial encounterPreviously T45.1X2A

T45.AX2DPoisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm, subsequent encounterPreviously T45.1X2D

T45.AX2SPoisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm, sequelaPreviously T45.1X2S

T45.AX3APoisoning by immune checkpoint inhibitors and immunostimulant drugs, assault, initial encounterPreviously T45.1X3A

T45.AX3DPoisoning by immune checkpoint inhibitors and immunostimulant drugs, assault, subsequent encounterPreviously T45.1X3D

T45.AX3SPoisoning by immune checkpoint inhibitors and immunostimulant drugs, assault, sequelaPreviously T45.1X3S

T45.AX4APoisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined, initial encounterPreviously T45.1X4A

T45.AX4DPoisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined, subsequent encounterPreviously T45.1X4D

T45.AX4SPoisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined, sequelaPreviously T45.1X4S

T45.AX5AAdverse effect of immune checkpoint inhibitors and immunostimulant drugs, initial encounterPreviously T45.1X5A

T45.AX5DAdverse effect of immune checkpoint inhibitors and immunostimulant drugs, subsequent encounterPreviously T45.1X5D

T45.AX5SAdverse effect of immune checkpoint inhibitors and immunostimulant drugs, sequelaPreviously T45.1X5S

T45.AX6AUnderdosing of immune checkpoint inhibitors and immunostimulant drugs, initial encounterPreviously T45.1X6A

T45.AX6DUnderdosing of immune checkpoint inhibitors and immunostimulant drugs, subsequent encounterPreviously T45.1X6D

T45.AX6SUnderdosing of immune checkpoint inhibitors and immunostimulant drugs, sequelaPreviously T45.1X6S

T81.320ADisruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure, initial encounterPreviously T81.32XA

T81.320DDisruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure, subsequent encounterPreviously T81.32XD

T81.320SDisruption or dehiscence of gastrointestinal tract anastomosis, repair, or closure, sequelaPreviously T81.32XS

T81.321ADisruption or dehiscence of closure of internal operation (surgical) wound of abdominal wall muscle or fascia, initial encounterPreviously T81.32XA

T81.321DDisruption or dehiscence of closure of internal operation (surgical) wound of abdominal wall muscle or fascia, subsequent encounterPreviously T81.32XD

T81.321SDisruption or dehiscence of closure of internal operation (surgical) wound of abdominal wall muscle or fascia, sequelaPreviously T81.32XS

T81.328ADisruption or dehiscence of closure of other specified internal operation (surgical) wound, initial encounterPreviously T81.32XA

T81.328DDisruption or dehiscence of closure of other specified internal operation (surgical) wound, subsequent encounterPreviously T81.32XD

T81.328SDisruption or dehiscence of closure of other specified internal operation (surgical) wound, sequelaPreviously T81.32XS

T81.329ADeep disruption or dehiscence of operation wound, unspecified, initial encounterPreviously T81.32XA

T81.329DDeep disruption or dehiscence of operation wound, unspecified, subsequent encounterPreviously T81.32XD

T81.329SDeep disruption or dehiscence of operation wound, unspecified, sequelaPreviously T81.32XS

Chapter 21: Z00–Z99 (Factors Influencing Health Status and Contact with Health Services)25 codes

Z15.1Genetic susceptibility to epilepsy and neurodevelopmental disordersPreviously Z15.89

Z15.2Genetic susceptibility to obesityPreviously Z15.89

Z17.21Progesterone receptor positive statusPreviously None

Z17.22Progesterone receptor negative statusPreviously None

Z17.31Human epidermal growth factor receptor 2 positive statusPreviously None

Z17.32Human epidermal growth factor receptor 2 negative statusPreviously None

Z17.410Hormone receptor positive with human epidermal growth factor receptor 2 positive statusPreviously None

Z17.411Hormone receptor positive with human epidermal growth factor receptor 2 negative statusPreviously None

Z17.420Hormone receptor negative with human epidermal growth factor receptor 2 positive statusPreviously None

Z17.421Hormone receptor negative with human epidermal growth factor receptor 2 negative statusPreviously None

Z51.AEncounter for sepsis aftercarePreviously Z51.89

Z59.71Insufficient health insurance coveragePreviously Z59.7

Z59.72Insufficient welfare supportPreviously Z59.7

Z67.A1Duffy nullPreviously None

Z67.A2Duffy a positivePreviously None

Z67.A3Duffy b positivePreviously None

Z67.A4Duffy a and b positivePreviously None

Z68.55Body mass index [BMI] pediatric, 120% of the 95th percentile for age to less than 140% of the 95th percentile for agePreviously Z68.54

Z68.56Body mass index [BMI] pediatric, greater than or equal to 140% of the 95th percentile for agePreviously Z68.54

Z83.72Family history of familial adenomatous polyposisPreviously Z83.718

Z86.0100Personal history of colon polyps, unspecifiedPreviously Z86.010

Z86.0101Personal history of adenomatous and serrated colon polypsPreviously Z86.010

Z86.0102Personal history of hyperplastic colon polypsPreviously Z86.010

Z86.0109Personal history of other colon polypsPreviously Z86.010

Z92.26Personal history of immune checkpoint inhibitor therapyPreviously Z92.29