D55-D59Not billable, use a more specific code below
Hemolytic anemias (D55-D59)
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Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
There are no chapter-specific rules for Chapter 3 yet, so the general rules in Section I.B apply.
All codes under D55-D59
D55-D59 can't be used on a claim. Pick a billable code below; grey headings group them.
- D55Anemia due to enzyme disorders
- D55.0Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
- D55.1Anemia due to other disorders of glutathione metabolism
- D55.2Anemia due to disorders of glycolytic enzymes
- D55.21Anemia due to pyruvate kinase deficiency
- D55.29Anemia due to other disorders of glycolytic enzymes
- D55.3Anemia due to disorders of nucleotide metabolism
- D55.8Other anemias due to enzyme disorders
- D55.9Anemia due to enzyme disorder, unspecified
- D56Thalassemia
- D56.0Alpha thalassemia
- D56.1Beta thalassemia
- D56.2Delta-beta thalassemia
- D56.3Thalassemia minor
- D56.4Hereditary persistence of fetal hemoglobin [HPFH]
- D56.5Hemoglobin E-beta thalassemia
- D56.8Other thalassemias
- D56.9Thalassemia, unspecified
- D57Sickle-cell disorders
- D57.0Hb-SS disease with crisis
- D57.00Hb-SS disease with crisis, unspecified
- D57.01Hb-SS disease with acute chest syndrome
- D57.02Hb-SS disease with splenic sequestration
- D57.03Hb-SS disease with cerebral vascular involvement
- D57.04Hb-SS disease with dactylitis
- D57.09Hb-SS disease with crisis with other specified complication
- D57.1Sickle-cell disease without crisis
- D57.2Sickle-cell/Hb-C disease
- D57.20Sickle-cell/Hb-C disease without crisis
- D57.21Sickle-cell/Hb-C disease with crisis
- D57.211Sickle-cell/Hb-C disease with acute chest syndrome
- D57.212Sickle-cell/Hb-C disease with splenic sequestration
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
- D57.214Sickle-cell/Hb-C disease with dactylitis
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
- D57.219Sickle-cell/Hb-C disease with crisis, unspecified
- D57.3Sickle-cell trait
- D57.4Sickle-cell thalassemia
- D57.40Sickle-cell thalassemia without crisis
- D57.41Sickle-cell thalassemia, unspecified, with crisis
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- D57.414Sickle-cell thalassemia, unspecified, with dactylitis
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- D57.419Sickle-cell thalassemia, unspecified, with crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.43Sickle-cell thalassemia beta zero with crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.45Sickle-cell thalassemia beta plus with crisis
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
- D57.8Other sickle-cell disorders
- D57.80Other sickle-cell disorders without crisis
- D57.81Other sickle-cell disorders with crisis
- D57.811Other sickle-cell disorders with acute chest syndrome
- D57.812Other sickle-cell disorders with splenic sequestration
- D57.813Other sickle-cell disorders with cerebral vascular involvement
- D57.814Other sickle-cell disorders with dactylitis
- D57.818Other sickle-cell disorders with crisis with other specified complication
- D57.819Other sickle-cell disorders with crisis, unspecified
- D58Other hereditary hemolytic anemias
- D58.0Hereditary spherocytosis
- D58.1Hereditary elliptocytosis
- D58.2Other hemoglobinopathies
- D58.8Other specified hereditary hemolytic anemias
- D58.9Hereditary hemolytic anemia, unspecified
- D59Acquired hemolytic anemia
- D59.0Drug-induced autoimmune hemolytic anemia
- D59.1Other autoimmune hemolytic anemias
- D59.10Autoimmune hemolytic anemia, unspecified
- D59.11Warm autoimmune hemolytic anemia
- D59.12Cold autoimmune hemolytic anemia
- D59.13Mixed type autoimmune hemolytic anemia
- D59.19Other autoimmune hemolytic anemia
- D59.2Drug-induced nonautoimmune hemolytic anemia
- D59.3Hemolytic-uremic syndrome
- D59.30Hemolytic-uremic syndrome, unspecified
- D59.31Infection-associated hemolytic-uremic syndrome
- D59.32Hereditary hemolytic-uremic syndrome
- D59.39Other hemolytic-uremic syndrome
- D59.4Other nonautoimmune hemolytic anemias
- D59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- D59.6Hemoglobinuria due to hemolysis from other external causes
- D59.8Other acquired hemolytic anemias
- D59.9Acquired hemolytic anemia, unspecified
D55-D59 MS-DRGs
This code does not group to an MS-DRG as a principal diagnosis.
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Anemia
If you have anemia, your blood does not carry enough oxygen to the rest of your body. The most common cause of anemia is not having enough iron. Your body needs iron to make hemoglobin. Hemoglobin is an iron-rich protein that gives the red color to blood. It carries oxygen from the lungs to the rest of the body.
Read more about anemia on MedlinePlus