Sickle-cell disorders
In Hemolytic anemias (D55-D59), chapter 3: Diseases of the Blood and Blood-Forming Organs
43 billable codes under D57: 36 are an MCC; 42 map to HCC 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major), HCC 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Instructional notes
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
There are no chapter-specific rules for Chapter 3 yet, so the general rules in Section I.B apply.
All codes under D57
D57 can't be used on a claim. Pick a billable code below; grey headings group them.
- D57.0Hb-SS disease with crisis
- D57.00Hb-SS disease with crisis, unspecified
- D57.01Hb-SS disease with acute chest syndrome
- D57.02Hb-SS disease with splenic sequestration
- D57.03Hb-SS disease with cerebral vascular involvement
- D57.04Hb-SS disease with dactylitis
- D57.09Hb-SS disease with crisis with other specified complication
- D57.1Sickle-cell disease without crisis
- D57.2Sickle-cell/Hb-C disease
- D57.20Sickle-cell/Hb-C disease without crisis
- D57.21Sickle-cell/Hb-C disease with crisis
- D57.211Sickle-cell/Hb-C disease with acute chest syndrome
- D57.212Sickle-cell/Hb-C disease with splenic sequestration
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
- D57.214Sickle-cell/Hb-C disease with dactylitis
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
- D57.219Sickle-cell/Hb-C disease with crisis, unspecified
- D57.3Sickle-cell trait
- D57.4Sickle-cell thalassemia
- D57.40Sickle-cell thalassemia without crisis
- D57.41Sickle-cell thalassemia, unspecified, with crisis
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- D57.414Sickle-cell thalassemia, unspecified, with dactylitis
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- D57.419Sickle-cell thalassemia, unspecified, with crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.43Sickle-cell thalassemia beta zero with crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.45Sickle-cell thalassemia beta plus with crisis
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
- D57.8Other sickle-cell disorders
- D57.80Other sickle-cell disorders without crisis
- D57.81Other sickle-cell disorders with crisis
- D57.811Other sickle-cell disorders with acute chest syndrome
- D57.812Other sickle-cell disorders with splenic sequestration
- D57.813Other sickle-cell disorders with cerebral vascular involvement
- D57.814Other sickle-cell disorders with dactylitis
- D57.818Other sickle-cell disorders with crisis with other specified complication
- D57.819Other sickle-cell disorders with crisis, unspecified
D57 MS-DRGs
As the principal diagnosis, the billable codes under D57 group to MS-DRG 811, 812, 791, or 793 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 811 Red Blood Cell Disorders with MCC (43 of 43 codes)
- DRG 812 Red Blood Cell Disorders without MCC (43 of 43 codes)
- DRG 791 Prematurity with Major Problems (21 of 43 codes)
- DRG 793 Full Term Neonate with Major Problems (21 of 43 codes)
Other codes that refer to D57
Notes on these codes point to D57.
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Sickle Cell Disease
Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells. The cells are supposed to be disc-shaped, but instead they are crescent, or sickle, shaped.
Read more about sickle cell disease on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.