D56.1

Billable
ChapterD50–D89
Ranksubcategory
Official Description

Beta thalassemia

Metadata & Insights
  • •2026 ICD-10-CM Edition - Effective October 1, 2025.
  • •Billable/specific code (valid for reimbursement).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

Instructional Notes

Includes
  • Beta thalassemia major
  • Cooley's anemia
  • Homozygous beta thalassemia
  • Severe beta thalassemia
  • Thalassemia intermedia
  • Thalassemia major
Excludes1(Not coded here)
  • beta thalassemia minor (D56.3)
  • beta thalassemia trait (D56.3)
  • delta-beta thalassemia (D56.2)
  • hemoglobin E-beta thalassemia (D56.5)
  • sickle-cell beta thalassemia (D57.4-)
General instructions are available for the parent sections:
View CH3 NotesView D56 Notes

Clinical Hierarchy

CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D55-D59Hemolytic anemias (D55-D59)
D56Thalassemia
D56.1Beta thalassemia

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D56.1:

categoryD56
Thalassemia
View context instructions
chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to D56.1. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

10 raw paths
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)4 unique routes
Cooley's (erythroblastic)→D56.1
erythroblastic(2 variants)
familial→D56.1
of childhood→D56.1
familial erythroblastic→D56.1
Cooley's anemia1 unique routes
Direct index entry→D56.1
Thalassemia (anemia) (disease)5 unique routes
beta (severe)→D56.1(3 variants)
homozygous→D56.1
major→D56.1
intermedia→D56.1
major→D56.1

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 791
Prematurity with Major Problems
DRG 793
Full Term Neonate with Major Problems
DRG 811
Red Blood Cell Disorders with MCC
DRG 812
Red Blood Cell Disorders without MCC

Cross Reference

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