D56

Non-Billable
ChapterD50–D89
Rankcategory
Official Description

Thalassemia

Metadata & Insights
  • •2026 ICD-10-CM Edition - Effective October 1, 2025.
  • •Non-billable category (requires more specific sub-code).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

CH3 Parent Instructions

Excludes2(Not included here)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Instructional Notes

Excludes1(Not coded here)
  • sickle-cell thalassemia (D57.4-)

Clinical Hierarchy

CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D55-D59Hemolytic anemias (D55-D59)
D56Thalassemia
D56.0Alpha thalassemia
D56.1Beta thalassemia
D56.2Delta-beta thalassemia
D56.3Thalassemia minor
D56.4Hereditary persistence of fetal hemoglobin [HPFH]
D56.5Hemoglobin E-beta thalassemia
D56.8Other thalassemias
D56.9Thalassemia, unspecified

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D56:

chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to D56. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

25 raw paths
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)9 unique routes
Cooley's (erythroblastic)→D56
erythroblastic(2 variants)
familial→D56
of childhood→D56
familial erythroblastic→D56
Mediterranean (with other hemoglobinopathy)→D56
microcytic (hypochromic)
familial→D56
microelliptopoikilocytic (Rietti-Greppi- Micheli)→D56
Rietti-Greppi-Micheli→D56
thalassemia→D56
Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute)1 unique routes
in (due to)
thalassemia NEC→D56
Cooley's anemia1 unique routes
Direct index entry→D56
Disease, diseased9 unique routes
hemoglobin or Hb(8 variants)
abnormal (mixed) NEC
with thalassemia→D56
Bart's→D56
C (Hb-C)
thalassemia→D56
E-beta thalassemia→D56
H (Hb-H) (thalassemia)→D56(3 variants)
Constant Spring→D56
with other abnormal hemoglobin NEC→D56
I thalassemia→D56
high fetal gene or hemoglobin thalassemia→D56
Hb (abnormal)1 unique routes
Bart's disease→D56
Hemoglobin3 unique routes
E-beta thalassemia→D56
fetal, hereditary persistence (HPFH)→D56
H Constant Spring→D56
Hemoglobinopathy (mixed)1 unique routes
with thalassemia→D56

MS-DRG Classification

2026

No direct MS-DRG triggers identified.

Cross Reference

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