Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R46.4

    Slowness and poor responsiveness

  • R46.5

    Suspiciousness and marked evasiveness

  • R46.6

    Undue concern and preoccupation with stressful events

  • R46.7

    Verbosity and circumstantial detail obscuring reason for contact

  • R46.8

    Other symptoms and signs involving appearance and behavior

  • R46.81

    Obsessive-compulsive behavior

  • R46.89

    Other symptoms and signs involving appearance and behavior

  • R47

    Speech disturbances, not elsewhere classified

  • R47.0

    Dysphasia and aphasia

  • R47.01

    Aphasia

  • R47.02

    Dysphasia

  • R47.1

    Dysarthria and anarthria

  • R47.8

    Other speech disturbances

  • R47.81

    Slurred speech

  • R47.82

    Fluency disorder in conditions classified elsewhere

  • R47.89

    Other speech disturbances

  • R47.9

    Unspecified speech disturbances

  • R48

    Dyslexia and other symbolic dysfunctions, not elsewhere classified

  • R48.0

    Dyslexia and alexia

  • R48.1

    Agnosia

  • R48.2

    Apraxia

  • R48.3

    Visual agnosia

  • R48.8

    Other symbolic dysfunctions

  • R48.9

    Unspecified symbolic dysfunctions

  • R49

    Voice and resonance disorders

  • R49.0

    Dysphonia

  • R49.1

    Aphonia

  • R49.2

    Hypernasality and hyponasality

  • R49.21

    Hypernasality

  • R49.22

    Hyponasality

  • R49.8

    Other voice and resonance disorders

  • R49.9

    Unspecified voice and resonance disorder

  • R50

    Fever of other and unknown origin

  • R50.2

    Drug induced fever

  • R50.8

    Other specified fever

  • R50.81

    Fever presenting with conditions classified elsewhere

  • R50.82

    Postprocedural fever

  • R50.83

    Postvaccination fever

  • R50.84

    Febrile nonhemolytic transfusion reaction

  • R50.9

    Fever, unspecified

  • R51

    Headache

  • R51.0

    Headache with orthostatic component, not elsewhere classified

  • R51.9

    Headache, unspecified

  • R52

    Pain, unspecified

  • R53

    Malaise and fatigue

  • R53.0

    Neoplastic (malignant) related fatigue

  • R53.1

    Weakness

  • R53.2

    Functional quadriplegia

  • R53.8

    Other malaise and fatigue

  • R53.81

    Other malaise

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