Malaise and fatigue
In General symptoms and signs (R50-R69), chapter 18: Symptoms, Signs and Abnormal Clinical and Laboratory Findings
6 billable codes under R53: 1 is an MCC; 1 map to HCC 180 (Quadriplegia).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Covers when to report symptom, sign, and abnormal finding codes (R00-R99), plus specific rules for falls, coma scales, non-infectious SIRS, death NOS, and NIHSS scores.
- Use of symptom codes (page 75)
- Use of a symptom code with a definitive diagnosis code (page 75)
- Combination codes that include symptoms (page 75)
- Repeated falls (page 76)
- Coma (page 76)
- Functional quadriplegia (page 76)
- SIRS due to Non-Infectious Process (page 77)
- Death NOS (page 77)
All codes under R53
R53 can't be used on a claim. Pick a billable code below; grey headings group them.
R53 MS-DRGs
As the principal diagnosis, all 6 billable codes under R53 group to MS-DRG 947 or 948 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Fatigue
Fatigue is a feeling of weariness, tiredness, or lack of energy. It can interfere with your usual daily activities. Fatigue can be a normal response to physical activity, emotional stress, boredom, or lack of sleep. But sometimes it can be a sign of a mental or physical condition. If you have been feeling tired for weeks, contact your health care provider. They can help you find out what's causing your fatigue and recommend ways to relieve it.
Read more about fatigue on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
