Is ICD-10-CM code R53 billable?

No, R53 (Malaise and fatigue) is a non-billable ICD-10-CM code. It must be coded to a more specific subcategory before it can be used for reimbursement.

What chapter does ICD-10-CM code R53 belong to?

R53 belongs to Chapter 18 of the ICD-10-CM tabular list: R00–R99 (Symptoms, Signs and Abnormal Clinical and Laboratory Findings).

R53Non-billable

Malaise and fatigue

Symptoms, Signs and Abnormal Clinical and Laboratory Findings·General symptoms and signs (R50-R69)·category·FY 2026

Use a more specific code (3 billable, 1 non-billable)

R53.0Neoplastic (malignant) related fatigue R53.1Weakness R53.2Functional quadriplegia R53.8Other malaise and fatiguehas subcodes

CH18 Parent Instructions

Excludes2(Not included here. Code separately if applicable.)

abnormal findings on antenatal screening of mother (O28.-)
certain conditions originating in the perinatal period (P04-P96)
signs and symptoms classified in the body system chapters
signs and symptoms of breast (N63, N64.5)

Clinical Hierarchy

BillableHas subcodes

CH18Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

R50-R69General symptoms and signs (R50-R69)

R53Malaise and fatigueNot billable

R53.0Neoplastic (malignant) related fatigueBillable

R53.1WeaknessBillable

R53.2Functional quadriplegiaBillable

R53.8Other malaise and fatigueSubcodes

MS-DRG Classification

2026

No direct MS-DRG triggers identified.