Is ICD-10-CM code R65 billable?

No, R65 (Symptoms and signs specifically associated with systemic inflammation and infection) is a non-billable ICD-10-CM code. It must be coded to a more specific subcategory before it can be used for reimbursement.

What chapter does ICD-10-CM code R65 belong to?

R65 belongs to Chapter 18 of the ICD-10-CM tabular list: R00–R99 (Symptoms, Signs and Abnormal Clinical and Laboratory Findings).

R65Non-billable

Symptoms and signs specifically associated with systemic inflammation and infection

Symptoms, Signs and Abnormal Clinical and Laboratory Findings·General symptoms and signs (R50-R69)·category·FY 2026

Use a more specific code (0 billable, 2 non-billable)

R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious originhas subcodes R65.2Severe sepsishas subcodes

CH18 Parent Instructions

Excludes2(Not included here. Code separately if applicable.)

abnormal findings on antenatal screening of mother (O28.-)
certain conditions originating in the perinatal period (P04-P96)
signs and symptoms classified in the body system chapters
signs and symptoms of breast (N63, N64.5)

Clinical Hierarchy

BillableHas subcodes

CH18Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99)

R50-R69General symptoms and signs (R50-R69)

R65Symptoms and signs specifically associated with systemic inflammation and infectionNot billable

R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious originSubcodes

R65.2Severe sepsisSubcodes

MS-DRG Classification

2026

No direct MS-DRG triggers identified.