Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)

transitory endocrine and metabolic disorders specific to newborn (P70-P74)

All Codes Billable Only

Internal Codes

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E16.3|
Increased secretion of glucagon
E16.4|
Increased secretion of gastrin
E16.8|
Other specified disorders of pancreatic internal secretion
E16.9|
Disorder of pancreatic internal secretion, unspecified
E16.A|
Hypoglycemia level
E16.A1|
Hypoglycemia level 1
E16.A2|
Hypoglycemia level 2
E16.A3|
Hypoglycemia level 3
E20|
Hypoparathyroidism
E20.0|
Idiopathic hypoparathyroidism
E20.1|
Pseudohypoparathyroidism
E20.8|
Other hypoparathyroidism
E20.81|
Hypoparathyroidism due to impaired parathyroid hormone secretion
E20.810|
Autosomal dominant hypocalcemia
E20.811|
Secondary hypoparathyroidism in diseases classified elsewhere
E20.812|
Autoimmune hypoparathyroidism
E20.818|
Other specified hypoparathyroidism due to impaired parathyroid hormone secretion
E20.819|
Hypoparathyroidism due to impaired parathyroid hormone secretion, unspecified
E20.89|
Other specified hypoparathyroidism
E20.9|
Hypoparathyroidism, unspecified
E21|
Hyperparathyroidism and other disorders of parathyroid gland
E21.0|
Primary hyperparathyroidism
E21.1|
Secondary hyperparathyroidism, not elsewhere classified
E21.2|
Other hyperparathyroidism
E21.3|
Hyperparathyroidism, unspecified
E21.4|
Other specified disorders of parathyroid gland
E21.5|
Disorder of parathyroid gland, unspecified
E22|
Hyperfunction of pituitary gland
E22.0|
Acromegaly and pituitary gigantism
E22.1|
Hyperprolactinemia
E22.2|
Syndrome of inappropriate secretion of antidiuretic hormone
E22.8|
Other hyperfunction of pituitary gland
E22.9|
Hyperfunction of pituitary gland, unspecified
E23|
Hypofunction and other disorders of the pituitary gland
E23.0|
Hypopituitarism
E23.1|
Drug-induced hypopituitarism
E23.2|
Diabetes insipidus
E23.3|
Hypothalamic dysfunction, not elsewhere classified
E23.6|
Other disorders of pituitary gland
E23.7|
Disorder of pituitary gland, unspecified
E24|
Cushing's syndrome
E24.0|
Pituitary-dependent Cushing's disease
E24.1|
Nelson's syndrome
E24.2|
Drug-induced Cushing's syndrome
E24.3|
Ectopic ACTH syndrome
E24.4|
Alcohol-induced pseudo-Cushing's syndrome
E24.8|
Other Cushing's syndrome
E24.9|
Cushing's syndrome, unspecified
E25|
Adrenogenital disorders
E25.0|
Congenital adrenogenital disorders associated with enzyme deficiency

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