Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Internal Codes
  • E16.3

    Increased secretion of glucagon

  • E16.4

    Increased secretion of gastrin

  • E16.8

    Other specified disorders of pancreatic internal secretion

  • E16.9

    Disorder of pancreatic internal secretion, unspecified

  • E16.A

    Hypoglycemia level

  • E16.A1

    Hypoglycemia level 1

  • E16.A2

    Hypoglycemia level 2

  • E16.A3

    Hypoglycemia level 3

  • E20

    Hypoparathyroidism

  • E20.0

    Idiopathic hypoparathyroidism

  • E20.1

    Pseudohypoparathyroidism

  • E20.8

    Other hypoparathyroidism

  • E20.81

    Hypoparathyroidism due to impaired parathyroid hormone secretion

  • E20.810

    Autosomal dominant hypocalcemia

  • E20.811

    Secondary hypoparathyroidism in diseases classified elsewhere

  • E20.812

    Autoimmune hypoparathyroidism

  • E20.818

    Other specified hypoparathyroidism due to impaired parathyroid hormone secretion

  • E20.819

    Hypoparathyroidism due to impaired parathyroid hormone secretion, unspecified

  • E20.89

    Other specified hypoparathyroidism

  • E20.9

    Hypoparathyroidism, unspecified

  • E21

    Hyperparathyroidism and other disorders of parathyroid gland

  • E21.0

    Primary hyperparathyroidism

  • E21.1

    Secondary hyperparathyroidism, not elsewhere classified

  • E21.2

    Other hyperparathyroidism

  • E21.3

    Hyperparathyroidism, unspecified

  • E21.4

    Other specified disorders of parathyroid gland

  • E21.5

    Disorder of parathyroid gland, unspecified

  • E22

    Hyperfunction of pituitary gland

  • E22.0

    Acromegaly and pituitary gigantism

  • E22.1

    Hyperprolactinemia

  • E22.2

    Syndrome of inappropriate secretion of antidiuretic hormone

  • E22.8

    Other hyperfunction of pituitary gland

  • E22.9

    Hyperfunction of pituitary gland, unspecified

  • E23

    Hypofunction and other disorders of the pituitary gland

  • E23.0

    Hypopituitarism

  • E23.1

    Drug-induced hypopituitarism

  • E23.2

    Diabetes insipidus

  • E23.3

    Hypothalamic dysfunction, not elsewhere classified

  • E23.6

    Other disorders of pituitary gland

  • E23.7

    Disorder of pituitary gland, unspecified

  • E24

    Cushing's syndrome

  • E24.0

    Pituitary-dependent Cushing's disease

  • E24.1

    Nelson's syndrome

  • E24.2

    Drug-induced Cushing's syndrome

  • E24.3

    Ectopic ACTH syndrome

  • E24.4

    Alcohol-induced pseudo-Cushing's syndrome

  • E24.8

    Other Cushing's syndrome

  • E24.9

    Cushing's syndrome, unspecified

  • E25

    Adrenogenital disorders

  • E25.0

    Congenital adrenogenital disorders associated with enzyme deficiency

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