Is ICD-10-CM code E22 billable?

No, E22 (Hyperfunction of pituitary gland) is a non-billable ICD-10-CM code. It must be coded to a more specific subcategory before it can be used for reimbursement.

What chapter does ICD-10-CM code E22 belong to?

E22 belongs to Chapter 4 of the ICD-10-CM tabular list: E00–E89 (Endocrine, Nutritional and Metabolic Diseases).

E22Not billable, use a more specific code below

Hyperfunction of pituitary gland

In Disorders of other endocrine glands (E20-E35), chapter 4: Endocrine, Nutritional and Metabolic Diseases

5 billable codes under E22: 4 are a CC; 1 map to HCC 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.

Instructional notes

Excludes1: not coded here, use a different code

Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)

Also applies, from Disorders of other endocrine glands (E20-E35)

These notes sit on E20-E35 and apply to every code under it, including E22.

Excludes1: not coded here, use a different code

galactorrhea (N64.3)
gynecomastia (N62)

Official coding guidelines

From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.

Covers diabetes mellitus coding, including type, insulin and drug use, pump malfunction and secondary diabetes, plus obesity and obesity class codes.

Diabetes mellitus (page 39)
Obesity (page 42)

Read Section I.C.4 (page 39)

All codes under E22

E22 can't be used on a claim. Pick a billable code below; grey headings group them.

E22 MS-DRGs

As the principal diagnosis, all 5 billable codes under E22 group to MS-DRG 643, 644, or 645 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.

About the condition

Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Code history

Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.