Endocrine Disorders with MCC
Major Diagnostic Category 10·Grouped by diagnosis·FY 2027
MS-DRG 643 is a Medical Medicare Severity Diagnosis Related Group under Major Diagnostic Category 10 (MDC 10) with a Major Complication or Comorbidity (MCC). It maps to 174 ICD-10-CM diagnosis codes. For FY 2027 it carries a relative weight of 1.6139 with a geometric mean length of stay of 4.8 days and an arithmetic mean of 6.1 days. Hospitals use this grouping to determine reimbursement for inpatient stays under Medicare.
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FY 2027 payment data
From Table 5 of the FY 2027 IPPS Final Rule (CMS).
- Relative weight:
- 1.6139 (payment multiplier vs. the average case (1.0))
- Geometric mean stay:
- 4.8 days (used for transfer payments)
- Average stay:
- 6.1 days (arithmetic mean)
- Post-acute transfer policy:
- Yes (early transfers can be paid less)
Same condition, other severity levels
CMS splits one condition into separate DRGs by how sick the patient is. With MCC pays more than with CC, which pays more than without CC/MCC.
Diagnosis codes (174)
As the principal diagnosis, these ICD-10-CM codes can group to DRG 643. 100% of the codes listed are billable.
- A18.7Tuberculosis of adrenal glands
- A18.81Tuberculosis of thyroid gland
- B67.31Echinococcus granulosus infection, thyroid gland
- C72.9Malignant neoplasm of central nervous system, unspecified
- C74.00Malignant neoplasm of cortex of unspecified adrenal gland
- C74.01Malignant neoplasm of cortex of right adrenal gland
- C74.02Malignant neoplasm of cortex of left adrenal gland
- C74.10Malignant neoplasm of medulla of unspecified adrenal gland
- C74.11Malignant neoplasm of medulla of right adrenal gland
- C74.12Malignant neoplasm of medulla of left adrenal gland
- C74.90Malignant neoplasm of unspecified part of unspecified adrenal gland
- C74.91Malignant neoplasm of unspecified part of right adrenal gland
- C74.92Malignant neoplasm of unspecified part of left adrenal gland
- C75.0Malignant neoplasm of parathyroid gland
- C75.1Malignant neoplasm of pituitary gland
- C75.2Malignant neoplasm of craniopharyngeal duct
- C75.8Malignant neoplasm with pluriglandular involvement, unspecified
- C75.9Malignant neoplasm of endocrine gland, unspecified
- C79.70Secondary malignant neoplasm of unspecified adrenal gland
- C79.71Secondary malignant neoplasm of right adrenal gland
- C79.72Secondary malignant neoplasm of left adrenal gland
- D13.7Benign neoplasm of endocrine pancreas
- D33.9Benign neoplasm of central nervous system, unspecified
- D35.00Benign neoplasm of unspecified adrenal gland
- D35.01Benign neoplasm of right adrenal gland
- D35.02Benign neoplasm of left adrenal gland
- D35.1Benign neoplasm of parathyroid gland
- D35.2Benign neoplasm of pituitary gland
- D35.3Benign neoplasm of craniopharyngeal duct
- D35.7Benign neoplasm of other specified endocrine glands
- D35.9Benign neoplasm of endocrine gland, unspecified
- D44.0Neoplasm of uncertain behavior of thyroid gland
- D44.10Neoplasm of uncertain behavior of unspecified adrenal gland
- D44.11Neoplasm of uncertain behavior of right adrenal gland
- D44.12Neoplasm of uncertain behavior of left adrenal gland
- D44.2Neoplasm of uncertain behavior of parathyroid gland
- D44.3Neoplasm of uncertain behavior of pituitary gland
- D44.4Neoplasm of uncertain behavior of craniopharyngeal duct
- D44.9Neoplasm of uncertain behavior of unspecified endocrine gland
- D49.7Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system
- E00.0Congenital iodine-deficiency syndrome, neurological type
- E00.1Congenital iodine-deficiency syndrome, myxedematous type
- E00.2Congenital iodine-deficiency syndrome, mixed type
- E00.9Congenital iodine-deficiency syndrome, unspecified
- E01.0Iodine-deficiency related diffuse (endemic) goiter
- E01.1Iodine-deficiency related multinodular (endemic) goiter
- E01.2Iodine-deficiency related (endemic) goiter, unspecified
- E01.8Other iodine-deficiency related thyroid disorders and allied conditions
- E02Subclinical iodine-deficiency hypothyroidism
- E03.0Congenital hypothyroidism with diffuse goiter
- E03.1Congenital hypothyroidism without goiter
- E03.2Hypothyroidism due to medicaments and other exogenous substances
- E03.3Postinfectious hypothyroidism
- E03.8Other specified hypothyroidism
- E03.9Hypothyroidism, unspecified
- E04.0Nontoxic diffuse goiter
- E04.2Nontoxic multinodular goiter
- E04.8Other specified nontoxic goiter
- E04.9Nontoxic goiter, unspecified
- E07.0Hypersecretion of calcitonin
- E07.1Dyshormogenetic goiter
- E07.81Sick-euthyroid syndrome
- E16.0Drug-induced hypoglycemia without coma
- E16.1Other hypoglycemia
- E16.3Increased secretion of glucagon
- E16.8Other specified disorders of pancreatic internal secretion
- E16.9Disorder of pancreatic internal secretion, unspecified
- E16.A1Hypoglycemia level 1
- E16.A2Hypoglycemia level 2
- E16.A3Hypoglycemia level 3
- E20.0Idiopathic hypoparathyroidism
- E20.810Autosomal dominant hypocalcemia
- E20.811Secondary hypoparathyroidism in diseases classified elsewhere
- E20.812Autoimmune hypoparathyroidism
- E20.818Other specified hypoparathyroidism due to impaired parathyroid hormone secretion
- E20.819Hypoparathyroidism due to impaired parathyroid hormone secretion, unspecified
- E20.89Other specified hypoparathyroidism
- E20.9Hypoparathyroidism, unspecified
- E21.0Primary hyperparathyroidism
- E21.1Secondary hyperparathyroidism, not elsewhere classified
- E21.2Other hyperparathyroidism
- E21.3Hyperparathyroidism, unspecified
- E21.4Other specified disorders of parathyroid gland
- E21.5Disorder of parathyroid gland, unspecified
- E22.0Acromegaly and pituitary gigantism
- E22.1Hyperprolactinemia
- E22.2Syndrome of inappropriate secretion of antidiuretic hormone
- E22.8Other hyperfunction of pituitary gland
- E22.9Hyperfunction of pituitary gland, unspecified
- E23.0Hypopituitarism
- E23.1Drug-induced hypopituitarism
- E23.2Diabetes insipidus
- E23.3Hypothalamic dysfunction, not elsewhere classified
- E23.6Other disorders of pituitary gland
- E23.7Disorder of pituitary gland, unspecified
- E24.0Pituitary-dependent Cushing's disease
- E24.1Nelson's syndrome
- E24.2Drug-induced Cushing's syndrome
- E24.3Ectopic ACTH syndrome
- E24.4Alcohol-induced pseudo-Cushing's syndrome
- E24.8Other Cushing's syndrome
- E24.9Cushing's syndrome, unspecified
- E25.0Congenital adrenogenital disorders associated with enzyme deficiency
- E25.8Other adrenogenital disorders
- E25.9Adrenogenital disorder, unspecified
- E26.01Conn's syndrome
- E26.02Glucocorticoid-remediable aldosteronism
- E26.09Other primary hyperaldosteronism
- E26.1Secondary hyperaldosteronism
- E26.81Bartter's syndrome
- E26.89Other hyperaldosteronism
- E26.9Hyperaldosteronism, unspecified
- E27.0Other adrenocortical overactivity
- E27.1Primary adrenocortical insufficiency
- E27.2Addisonian crisis
- E27.3Drug-induced adrenocortical insufficiency
- E27.40Unspecified adrenocortical insufficiency
- E27.49Other adrenocortical insufficiency
- E27.5Adrenomedullary hyperfunction
- E27.8Other specified disorders of adrenal gland
- E27.9Disorder of adrenal gland, unspecified
- E29.0Testicular hyperfunction
- E29.1Testicular hypofunction
- E29.8Other testicular dysfunction
- E29.9Testicular dysfunction, unspecified
- E30.0Delayed puberty
- E30.1Precocious puberty
- E30.8Other disorders of puberty
- E30.9Disorder of puberty, unspecified
- E31.0Autoimmune polyglandular failure
- E31.1Polyglandular hyperfunction
- E31.20Multiple endocrine neoplasia [MEN] syndrome, unspecified
- E31.21Multiple endocrine neoplasia [MEN] type I
- E31.22Multiple endocrine neoplasia [MEN] type IIA
- E31.23Multiple endocrine neoplasia [MEN] type IIB
- E31.8Other polyglandular dysfunction
- E31.9Polyglandular dysfunction, unspecified
- E34.00Carcinoid syndrome, unspecified
- E34.01Carcinoid heart syndrome
- E34.09Other carcinoid syndrome
- E34.1Other hypersecretion of intestinal hormones
- E34.2Ectopic hormone secretion, not elsewhere classified
- E34.30Short stature due to endocrine disorder, unspecified
- E34.31Constitutional short stature
- E34.321Primary insulin-like growth factor-1 (IGF-1) deficiency
- E34.322Insulin-like growth factor-1 (IGF-1) resistance
- E34.328Other genetic causes of short stature
- E34.329Unspecified genetic causes of short stature
- E34.39Other short stature due to endocrine disorder
- E34.4Constitutional tall stature
- E34.50Androgen insensitivity syndrome, unspecified
- E34.51Complete androgen insensitivity syndrome
- E34.52Partial androgen insensitivity syndrome
- E34.8Other specified endocrine disorders
- E34.9Endocrine disorder, unspecified
- E89.0Postprocedural hypothyroidism
- E89.2Postprocedural hypoparathyroidism
- E89.3Postprocedural hypopituitarism
- E89.5Postprocedural testicular hypofunction
- E89.6Postprocedural adrenocortical (-medullary) hypofunction
- Q89.1Congenital malformations of adrenal gland
- Q89.2Congenital malformations of other endocrine glands
- R94.6Abnormal results of thyroid function studies
- R94.7Abnormal results of other endocrine function studies
- S11.039SUnspecified open wound of vocal cord, sequela
- S11.10XSUnspecified open wound of thyroid gland, sequela
- S11.11XSLaceration without foreign body of thyroid gland, sequela
- S11.12XSLaceration with foreign body of thyroid gland, sequela
- S11.13XSPuncture wound without foreign body of thyroid gland, sequela
- S11.14XSPuncture wound with foreign body of thyroid gland, sequela
- S37.812AContusion of adrenal gland, initial encounter
- S37.813ALaceration of adrenal gland, initial encounter
- S37.818AOther injury of adrenal gland, initial encounter
- S37.819AUnspecified injury of adrenal gland, initial encounter
