DRG 643
Medical DRGEndocrine Disorders with MCC
What is MS-DRG 643?
MS-DRG 643 is a Medical Medicare Severity Diagnosis Related Group under Major Diagnostic Category 10 (MDC 10) with a Major Complication or Comorbidity (MCC). It maps to 174 ICD-10-CM diagnosis codes. For FY 2026 it carries a relative weight of 1.6461 with a geometric mean length of stay of 4.9 days and an arithmetic mean of 6.3 days. Hospitals use this grouping to determine reimbursement for inpatient stays under Medicare.
FY 2026 Payment Data
Official values from Table 5 of the FY 2026 IPPS Final Rule (CMS).
Related MS-DRGs in This Severity Group
The same clinical condition is split into separate DRGs by complication severity. MCC pays more than CC, which pays more than no CC/MCC.
Linked ICD-10-CM Diagnosis Mappings
- A18.7
Tuberculosis of adrenal glands
BillableChapter 1 - A18.81
Tuberculosis of thyroid gland
BillableChapter 1 - B67.31
Echinococcus granulosus infection, thyroid gland
BillableChapter 1 - C72.9
Malignant neoplasm of central nervous system, unspecified
BillableChapter 2 - C74.00
Malignant neoplasm of cortex of unspecified adrenal gland
BillableChapter 2 - C74.01
Malignant neoplasm of cortex of right adrenal gland
BillableChapter 2 - C74.02
Malignant neoplasm of cortex of left adrenal gland
BillableChapter 2 - C74.10
Malignant neoplasm of medulla of unspecified adrenal gland
BillableChapter 2 - C74.11
Malignant neoplasm of medulla of right adrenal gland
BillableChapter 2 - C74.12
Malignant neoplasm of medulla of left adrenal gland
BillableChapter 2 - C74.90
Malignant neoplasm of unspecified part of unspecified adrenal gland
BillableChapter 2 - C74.91
Malignant neoplasm of unspecified part of right adrenal gland
BillableChapter 2 - C74.92
Malignant neoplasm of unspecified part of left adrenal gland
BillableChapter 2 - C75.0
Malignant neoplasm of parathyroid gland
BillableChapter 2 - C75.1
Malignant neoplasm of pituitary gland
BillableChapter 2 - C75.2
Malignant neoplasm of craniopharyngeal duct
BillableChapter 2 - C75.8
Malignant neoplasm with pluriglandular involvement, unspecified
BillableChapter 2 - C75.9
Malignant neoplasm of endocrine gland, unspecified
BillableChapter 2 - C79.70
Secondary malignant neoplasm of unspecified adrenal gland
BillableChapter 2 - C79.71
Secondary malignant neoplasm of right adrenal gland
BillableChapter 2 - C79.72
Secondary malignant neoplasm of left adrenal gland
BillableChapter 2 - D13.7
Benign neoplasm of endocrine pancreas
BillableChapter 2 - D33.9
Benign neoplasm of central nervous system, unspecified
BillableChapter 2 - D35.00
Benign neoplasm of unspecified adrenal gland
BillableChapter 2 - D35.01
Benign neoplasm of right adrenal gland
BillableChapter 2 - D35.02
Benign neoplasm of left adrenal gland
BillableChapter 2 - D35.1
Benign neoplasm of parathyroid gland
BillableChapter 2 - D35.2
Benign neoplasm of pituitary gland
BillableChapter 2 - D35.3
Benign neoplasm of craniopharyngeal duct
BillableChapter 2 - D35.7
Benign neoplasm of other specified endocrine glands
BillableChapter 2 - D35.9
Benign neoplasm of endocrine gland, unspecified
BillableChapter 2 - D44.0
Neoplasm of uncertain behavior of thyroid gland
BillableChapter 2 - D44.10
Neoplasm of uncertain behavior of unspecified adrenal gland
BillableChapter 2 - D44.11
Neoplasm of uncertain behavior of right adrenal gland
BillableChapter 2 - D44.12
Neoplasm of uncertain behavior of left adrenal gland
BillableChapter 2 - D44.2
Neoplasm of uncertain behavior of parathyroid gland
BillableChapter 2 - D44.3
Neoplasm of uncertain behavior of pituitary gland
BillableChapter 2 - D44.4
Neoplasm of uncertain behavior of craniopharyngeal duct
BillableChapter 2 - D44.9
Neoplasm of uncertain behavior of unspecified endocrine gland
BillableChapter 2 - D49.7
Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system
BillableChapter 2 - E00.0
Congenital iodine-deficiency syndrome, neurological type
BillableChapter 4 - E00.1
Congenital iodine-deficiency syndrome, myxedematous type
BillableChapter 4 - E00.2
Congenital iodine-deficiency syndrome, mixed type
BillableChapter 4 - E00.9
Congenital iodine-deficiency syndrome, unspecified
BillableChapter 4 - E01.0
Iodine-deficiency related diffuse (endemic) goiter
BillableChapter 4 - E01.1
Iodine-deficiency related multinodular (endemic) goiter
BillableChapter 4 - E01.2
Iodine-deficiency related (endemic) goiter, unspecified
BillableChapter 4 - E01.8
Other iodine-deficiency related thyroid disorders and allied conditions
BillableChapter 4 - E02
Subclinical iodine-deficiency hypothyroidism
BillableChapter 4 - E03.0
Congenital hypothyroidism with diffuse goiter
BillableChapter 4 - E03.1
Congenital hypothyroidism without goiter
BillableChapter 4 - E03.2
Hypothyroidism due to medicaments and other exogenous substances
BillableChapter 4 - E03.3
Postinfectious hypothyroidism
BillableChapter 4 - E03.8
Other specified hypothyroidism
BillableChapter 4 - E03.9
Hypothyroidism, unspecified
BillableChapter 4 - E04.0
Nontoxic diffuse goiter
BillableChapter 4 - E04.2
Nontoxic multinodular goiter
BillableChapter 4 - E04.8
Other specified nontoxic goiter
BillableChapter 4 - E04.9
Nontoxic goiter, unspecified
BillableChapter 4 - E07.0
Hypersecretion of calcitonin
BillableChapter 4 - E07.1
Dyshormogenetic goiter
BillableChapter 4 - E07.81
Sick-euthyroid syndrome
BillableChapter 4 - E16.0
Drug-induced hypoglycemia without coma
BillableChapter 4 - E16.1
Other hypoglycemia
BillableChapter 4 - E16.3
Increased secretion of glucagon
BillableChapter 4 - E16.8
Other specified disorders of pancreatic internal secretion
BillableChapter 4 - E16.9
Disorder of pancreatic internal secretion, unspecified
BillableChapter 4 - E16.A1
Hypoglycemia level 1
BillableChapter 4 - E16.A2
Hypoglycemia level 2
BillableChapter 4 - E16.A3
Hypoglycemia level 3
BillableChapter 4 - E20.0
Idiopathic hypoparathyroidism
BillableChapter 4 - E20.810
Autosomal dominant hypocalcemia
BillableChapter 4 - E20.811
Secondary hypoparathyroidism in diseases classified elsewhere
BillableChapter 4 - E20.812
Autoimmune hypoparathyroidism
BillableChapter 4 - E20.818
Other specified hypoparathyroidism due to impaired parathyroid hormone secretion
BillableChapter 4 - E20.819
Hypoparathyroidism due to impaired parathyroid hormone secretion, unspecified
BillableChapter 4 - E20.89
Other specified hypoparathyroidism
BillableChapter 4 - E20.9
Hypoparathyroidism, unspecified
BillableChapter 4 - E21.0
Primary hyperparathyroidism
BillableChapter 4 - E21.1
Secondary hyperparathyroidism, not elsewhere classified
BillableChapter 4 - E21.2
Other hyperparathyroidism
BillableChapter 4 - E21.3
Hyperparathyroidism, unspecified
BillableChapter 4 - E21.4
Other specified disorders of parathyroid gland
BillableChapter 4 - E21.5
Disorder of parathyroid gland, unspecified
BillableChapter 4 - E22.0
Acromegaly and pituitary gigantism
BillableChapter 4 - E22.1
Hyperprolactinemia
BillableChapter 4 - E22.2
Syndrome of inappropriate secretion of antidiuretic hormone
BillableChapter 4 - E22.8
Other hyperfunction of pituitary gland
BillableChapter 4 - E22.9
Hyperfunction of pituitary gland, unspecified
BillableChapter 4 - E23.0
Hypopituitarism
BillableChapter 4 - E23.1
Drug-induced hypopituitarism
BillableChapter 4 - E23.2
Diabetes insipidus
BillableChapter 4 - E23.3
Hypothalamic dysfunction, not elsewhere classified
BillableChapter 4 - E23.6
Other disorders of pituitary gland
BillableChapter 4 - E23.7
Disorder of pituitary gland, unspecified
BillableChapter 4 - E24.0
Pituitary-dependent Cushing's disease
BillableChapter 4 - E24.1
Nelson's syndrome
BillableChapter 4 - E24.2
Drug-induced Cushing's syndrome
BillableChapter 4 - E24.3
Ectopic ACTH syndrome
BillableChapter 4 - E24.4
Alcohol-induced pseudo-Cushing's syndrome
BillableChapter 4 - E24.8
Other Cushing's syndrome
BillableChapter 4 - E24.9
Cushing's syndrome, unspecified
BillableChapter 4 - E25.0
Congenital adrenogenital disorders associated with enzyme deficiency
BillableChapter 4 - E25.8
Other adrenogenital disorders
BillableChapter 4 - E25.9
Adrenogenital disorder, unspecified
BillableChapter 4 - E26.01
Conn's syndrome
BillableChapter 4 - E26.02
Glucocorticoid-remediable aldosteronism
BillableChapter 4 - E26.09
Other primary hyperaldosteronism
BillableChapter 4 - E26.1
Secondary hyperaldosteronism
BillableChapter 4 - E26.81
Bartter's syndrome
BillableChapter 4 - E26.89
Other hyperaldosteronism
BillableChapter 4 - E26.9
Hyperaldosteronism, unspecified
BillableChapter 4 - E27.0
Other adrenocortical overactivity
BillableChapter 4 - E27.1
Primary adrenocortical insufficiency
BillableChapter 4 - E27.2
Addisonian crisis
BillableChapter 4 - E27.3
Drug-induced adrenocortical insufficiency
BillableChapter 4 - E27.40
Unspecified adrenocortical insufficiency
BillableChapter 4 - E27.49
Other adrenocortical insufficiency
BillableChapter 4 - E27.5
Adrenomedullary hyperfunction
BillableChapter 4 - E27.8
Other specified disorders of adrenal gland
BillableChapter 4 - E27.9
Disorder of adrenal gland, unspecified
BillableChapter 4 - E29.0
Testicular hyperfunction
BillableChapter 4 - E29.1
Testicular hypofunction
BillableChapter 4 - E29.8
Other testicular dysfunction
BillableChapter 4 - E29.9
Testicular dysfunction, unspecified
BillableChapter 4 - E30.0
Delayed puberty
BillableChapter 4 - E30.1
Precocious puberty
BillableChapter 4 - E30.8
Other disorders of puberty
BillableChapter 4 - E30.9
Disorder of puberty, unspecified
BillableChapter 4 - E31.0
Autoimmune polyglandular failure
BillableChapter 4 - E31.1
Polyglandular hyperfunction
BillableChapter 4 - E31.20
Multiple endocrine neoplasia [MEN] syndrome, unspecified
BillableChapter 4 - E31.21
Multiple endocrine neoplasia [MEN] type I
BillableChapter 4 - E31.22
Multiple endocrine neoplasia [MEN] type IIA
BillableChapter 4 - E31.23
Multiple endocrine neoplasia [MEN] type IIB
BillableChapter 4 - E31.8
Other polyglandular dysfunction
BillableChapter 4 - E31.9
Polyglandular dysfunction, unspecified
BillableChapter 4 - E34.00
Carcinoid syndrome, unspecified
BillableChapter 4 - E34.01
Carcinoid heart syndrome
BillableChapter 4 - E34.09
Other carcinoid syndrome
BillableChapter 4 - E34.1
Other hypersecretion of intestinal hormones
BillableChapter 4 - E34.2
Ectopic hormone secretion, not elsewhere classified
BillableChapter 4 - E34.30
Short stature due to endocrine disorder, unspecified
BillableChapter 4 - E34.31
Constitutional short stature
BillableChapter 4 - E34.321
Primary insulin-like growth factor-1 (IGF-1) deficiency
BillableChapter 4 - E34.322
Insulin-like growth factor-1 (IGF-1) resistance
BillableChapter 4 - E34.328
Other genetic causes of short stature
BillableChapter 4 - E34.329
Unspecified genetic causes of short stature
BillableChapter 4 - E34.39
Other short stature due to endocrine disorder
BillableChapter 4 - E34.4
Constitutional tall stature
BillableChapter 4 - E34.50
Androgen insensitivity syndrome, unspecified
BillableChapter 4 - E34.51
Complete androgen insensitivity syndrome
BillableChapter 4 - E34.52
Partial androgen insensitivity syndrome
BillableChapter 4 - E34.8
Other specified endocrine disorders
BillableChapter 4 - E34.9
Endocrine disorder, unspecified
BillableChapter 4 - E89.0
Postprocedural hypothyroidism
BillableChapter 4 - E89.2
Postprocedural hypoparathyroidism
BillableChapter 4 - E89.3
Postprocedural hypopituitarism
BillableChapter 4 - E89.5
Postprocedural testicular hypofunction
BillableChapter 4 - E89.6
Postprocedural adrenocortical (-medullary) hypofunction
BillableChapter 4 - Q89.1
Congenital malformations of adrenal gland
BillableChapter 17 - Q89.2
Congenital malformations of other endocrine glands
BillableChapter 17 - R94.6
Abnormal results of thyroid function studies
BillableChapter 18 - R94.7
Abnormal results of other endocrine function studies
BillableChapter 18 - S11.039S
Unspecified open wound of vocal cord, sequela
BillableChapter 19 - S11.10XS
Unspecified open wound of thyroid gland, sequela
BillableChapter 19 - S11.11XS
Laceration without foreign body of thyroid gland, sequela
BillableChapter 19 - S11.12XS
Laceration with foreign body of thyroid gland, sequela
BillableChapter 19 - S11.13XS
Puncture wound without foreign body of thyroid gland, sequela
BillableChapter 19 - S11.14XS
Puncture wound with foreign body of thyroid gland, sequela
BillableChapter 19 - S37.812A
Contusion of adrenal gland, initial encounter
BillableChapter 19 - S37.813A
Laceration of adrenal gland, initial encounter
BillableChapter 19 - S37.818A
Other injury of adrenal gland, initial encounter
BillableChapter 19 - S37.819A
Unspecified injury of adrenal gland, initial encounter
BillableChapter 19