Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Internal Codes
  • E25.8|

    Other adrenogenital disorders

  • E25.9|

    Adrenogenital disorder, unspecified

  • E26|

    Hyperaldosteronism

  • E26.0|

    Primary hyperaldosteronism

  • E26.01|

    Conn's syndrome

  • E26.02|

    Glucocorticoid-remediable aldosteronism

  • E26.09|

    Other primary hyperaldosteronism

  • E26.1|

    Secondary hyperaldosteronism

  • E26.8|

    Other hyperaldosteronism

  • E26.81|

    Bartter's syndrome

  • E26.89|

    Other hyperaldosteronism

  • E26.9|

    Hyperaldosteronism, unspecified

  • E27|

    Other disorders of adrenal gland

  • E27.0|

    Other adrenocortical overactivity

  • E27.1|

    Primary adrenocortical insufficiency

  • E27.2|

    Addisonian crisis

  • E27.3|

    Drug-induced adrenocortical insufficiency

  • E27.4|

    Other and unspecified adrenocortical insufficiency

  • E27.40|

    Unspecified adrenocortical insufficiency

  • E27.49|

    Other adrenocortical insufficiency

  • E27.5|

    Adrenomedullary hyperfunction

  • E27.8|

    Other specified disorders of adrenal gland

  • E27.9|

    Disorder of adrenal gland, unspecified

  • E28|

    Ovarian dysfunction

  • E28.0|

    Estrogen excess

  • E28.1|

    Androgen excess

  • E28.2|

    Polycystic ovarian syndrome

  • E28.3|

    Primary ovarian failure

  • E28.31|

    Premature menopause

  • E28.310|

    Symptomatic premature menopause

  • E28.319|

    Asymptomatic premature menopause

  • E28.39|

    Other primary ovarian failure

  • E28.8|

    Other ovarian dysfunction

  • E28.9|

    Ovarian dysfunction, unspecified

  • E29|

    Testicular dysfunction

  • E29.0|

    Testicular hyperfunction

  • E29.1|

    Testicular hypofunction

  • E29.8|

    Other testicular dysfunction

  • E29.9|

    Testicular dysfunction, unspecified

  • E30|

    Disorders of puberty, not elsewhere classified

  • E30.0|

    Delayed puberty

  • E30.1|

    Precocious puberty

  • E30.8|

    Other disorders of puberty

  • E30.9|

    Disorder of puberty, unspecified

  • E31|

    Polyglandular dysfunction

  • E31.0|

    Autoimmune polyglandular failure

  • E31.1|

    Polyglandular hyperfunction

  • E31.2|

    Multiple endocrine neoplasia [MEN] syndromes

  • E31.20|

    Multiple endocrine neoplasia [MEN] syndrome, unspecified

  • E31.21|

    Multiple endocrine neoplasia [MEN] type I

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