Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Internal Codes
  • E25.8

    Other adrenogenital disorders

  • E25.9

    Adrenogenital disorder, unspecified

  • E26

    Hyperaldosteronism

  • E26.0

    Primary hyperaldosteronism

  • E26.01

    Conn's syndrome

  • E26.02

    Glucocorticoid-remediable aldosteronism

  • E26.09

    Other primary hyperaldosteronism

  • E26.1

    Secondary hyperaldosteronism

  • E26.8

    Other hyperaldosteronism

  • E26.81

    Bartter's syndrome

  • E26.89

    Other hyperaldosteronism

  • E26.9

    Hyperaldosteronism, unspecified

  • E27

    Other disorders of adrenal gland

  • E27.0

    Other adrenocortical overactivity

  • E27.1

    Primary adrenocortical insufficiency

  • E27.2

    Addisonian crisis

  • E27.3

    Drug-induced adrenocortical insufficiency

  • E27.4

    Other and unspecified adrenocortical insufficiency

  • E27.40

    Unspecified adrenocortical insufficiency

  • E27.49

    Other adrenocortical insufficiency

  • E27.5

    Adrenomedullary hyperfunction

  • E27.8

    Other specified disorders of adrenal gland

  • E27.9

    Disorder of adrenal gland, unspecified

  • E28

    Ovarian dysfunction

  • E28.0

    Estrogen excess

  • E28.1

    Androgen excess

  • E28.2

    Polycystic ovarian syndrome

  • E28.3

    Primary ovarian failure

  • E28.31

    Premature menopause

  • E28.310

    Symptomatic premature menopause

  • E28.319

    Asymptomatic premature menopause

  • E28.39

    Other primary ovarian failure

  • E28.8

    Other ovarian dysfunction

  • E28.9

    Ovarian dysfunction, unspecified

  • E29

    Testicular dysfunction

  • E29.0

    Testicular hyperfunction

  • E29.1

    Testicular hypofunction

  • E29.8

    Other testicular dysfunction

  • E29.9

    Testicular dysfunction, unspecified

  • E30

    Disorders of puberty, not elsewhere classified

  • E30.0

    Delayed puberty

  • E30.1

    Precocious puberty

  • E30.8

    Other disorders of puberty

  • E30.9

    Disorder of puberty, unspecified

  • E31

    Polyglandular dysfunction

  • E31.0

    Autoimmune polyglandular failure

  • E31.1

    Polyglandular hyperfunction

  • E31.2

    Multiple endocrine neoplasia [MEN] syndromes

  • E31.20

    Multiple endocrine neoplasia [MEN] syndrome, unspecified

  • E31.21

    Multiple endocrine neoplasia [MEN] type I

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