Chapter 3

D50–D89: Diseases of the Blood and Blood-Forming Organs

Diseases of the Blood and Blood-Forming Organs diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
All CodesBillable Only
Internal Codes
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  • D57.2—

    Sickle-cell/Hb-C disease

  • D57.20—

    Sickle-cell/Hb-C disease without crisis

  • D57.21—

    Sickle-cell/Hb-C disease with crisis

  • D57.211—

    Sickle-cell/Hb-C disease with acute chest syndrome

  • D57.212—

    Sickle-cell/Hb-C disease with splenic sequestration

  • D57.213—

    Sickle-cell/Hb-C disease with cerebral vascular involvement

  • D57.214—

    Sickle-cell/Hb-C disease with dactylitis

  • D57.218—

    Sickle-cell/Hb-C disease with crisis with other specified complication

  • D57.219—

    Sickle-cell/Hb-C disease with crisis, unspecified

  • D57.3—

    Sickle-cell trait

  • D57.4—

    Sickle-cell thalassemia

  • D57.40—

    Sickle-cell thalassemia without crisis

  • D57.41—

    Sickle-cell thalassemia, unspecified, with crisis

  • D57.411—

    Sickle-cell thalassemia, unspecified, with acute chest syndrome

  • D57.412—

    Sickle-cell thalassemia, unspecified, with splenic sequestration

  • D57.413—

    Sickle-cell thalassemia, unspecified, with cerebral vascular involvement

  • D57.414—

    Sickle-cell thalassemia, unspecified, with dactylitis

  • D57.418—

    Sickle-cell thalassemia, unspecified, with crisis with other specified complication

  • D57.419—

    Sickle-cell thalassemia, unspecified, with crisis

  • D57.42—

    Sickle-cell thalassemia beta zero without crisis

  • D57.43—

    Sickle-cell thalassemia beta zero with crisis

  • D57.431—

    Sickle-cell thalassemia beta zero with acute chest syndrome

  • D57.432—

    Sickle-cell thalassemia beta zero with splenic sequestration

  • D57.433—

    Sickle-cell thalassemia beta zero with cerebral vascular involvement

  • D57.434—

    Sickle-cell thalassemia beta zero with dactylitis

  • D57.438—

    Sickle-cell thalassemia beta zero with crisis with other specified complication

  • D57.439—

    Sickle-cell thalassemia beta zero with crisis, unspecified

  • D57.44—

    Sickle-cell thalassemia beta plus without crisis

  • D57.45—

    Sickle-cell thalassemia beta plus with crisis

  • D57.451—

    Sickle-cell thalassemia beta plus with acute chest syndrome

  • D57.452—

    Sickle-cell thalassemia beta plus with splenic sequestration

  • D57.453—

    Sickle-cell thalassemia beta plus with cerebral vascular involvement

  • D57.454—

    Sickle-cell thalassemia beta plus with dactylitis

  • D57.458—

    Sickle-cell thalassemia beta plus with crisis with other specified complication

  • D57.459—

    Sickle-cell thalassemia beta plus with crisis, unspecified

  • D57.8—

    Other sickle-cell disorders

  • D57.80—

    Other sickle-cell disorders without crisis

  • D57.81—

    Other sickle-cell disorders with crisis

  • D57.811—

    Other sickle-cell disorders with acute chest syndrome

  • D57.812—

    Other sickle-cell disorders with splenic sequestration

  • D57.813—

    Other sickle-cell disorders with cerebral vascular involvement

  • D57.814—

    Other sickle-cell disorders with dactylitis

  • D57.818—

    Other sickle-cell disorders with crisis with other specified complication

  • D57.819—

    Other sickle-cell disorders with crisis, unspecified

  • D58—

    Other hereditary hemolytic anemias

  • D58.0—

    Hereditary spherocytosis

  • D58.1—

    Hereditary elliptocytosis

  • D58.2—

    Other hemoglobinopathies

  • D58.8—

    Other specified hereditary hemolytic anemias

  • D58.9—

    Hereditary hemolytic anemia, unspecified

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