D57.453

Billable
ChapterD50–D89
Ranksubcategory
Official Description

Sickle-cell thalassemia beta plus with cerebral vascular involvement

Metadata & Insights
  • 2026 ICD-10-CM Edition - Effective October 1, 2025.
  • Billable/specific code (valid for reimbursement).
  • Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

Instructional Notes

Includes
  • HbS-beta plus with cerebral vascular involvement
  • Sickle-cell beta plus with cerebral vascular involvement
Code Also
  • , if applicable cerebral infarction (I63.-)
General instructions are available for the parent sections:

Clinical Hierarchy

CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D55-D59Hemolytic anemias (D55-D59)
D57Sickle-cell disorders
D57.4Sickle-cell thalassemia
D57.45Sickle-cell thalassemia beta plus with crisis
D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D57.453:

subcategoryD57.45
Sickle-cell thalassemia beta plus with crisis
View context instructions
subcategoryD57.4
Sickle-cell thalassemia
View context instructions
categoryD57
Sickle-cell disorders
View context instructions
chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Alphabetic Index Mentions

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2 raw paths

MS-DRG Classification

2026 v43.1

Cross Reference

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