All ICD10 Codes
C49Not billable, use a more specific code below

Malignant neoplasm of other connective and soft tissue

In Malignant neoplasms of mesothelial and soft tissue (C45-C49), chapter 2: Neoplasms

20 billable codes under C49: all are a CC; all map to HCC 21 (Lymphoma and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.

Advertisements

Instructional notes

Includes: conditions that are coded here

  • malignant neoplasm of blood vessel
  • malignant neoplasm of bursa
  • malignant neoplasm of cartilage
  • malignant neoplasm of fascia
  • malignant neoplasm of fat
  • malignant neoplasm of ligament, except uterine
  • malignant neoplasm of lymphatic vessel
  • malignant neoplasm of muscle
  • malignant neoplasm of synovia
  • malignant neoplasm of tendon (sheath)

Excludes1: not coded here, use a different code

  • malignant neoplasm of cartilage (of):
  • articular (C40-C41)
  • larynx (C32.3)
  • nose (C30.0)
  • malignant neoplasm of connective tissue of breast (C50.-)

Excludes2: not included here, code separately if applicable

  • Kaposi's sarcoma of soft tissue (C46.1)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
  • malignant neoplasm of peritoneum (C48.2)
  • malignant neoplasm of retroperitoneum (C48.0)
  • malignant neoplasm of uterine ligament (C57.3)
  • mesothelioma (C45.-)

Official coding guidelines

From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.

Rules for coding benign and malignant neoplasms: using the Neoplasm Table, sequencing primary and secondary sites, treatment encounters, complications, and current cancer versus personal history.

Read Section I.C.2 (page 32), 12 more topics

All codes under C49

C49 can't be used on a claim. Pick a billable code below; grey headings group them.

C49 MS-DRGs

As the principal diagnosis, the billable codes under C49 group to MS-DRG 542, 543, 544, 374, 375, or 376 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.

Other codes that refer to C49

Notes on these codes point to C49.

  • C40-C41 Excludes1: malignant neoplasm of synovia (C49.-)
  • M63 Code First: neoplasm (C49.-, C79.89, D21.-, D48.1-)
  • Z80.8 Includes: Conditions classifiable to C00-C14, C40-C49, C69-C79
  • Z85.8 Includes: Conditions classifiable to C00-C14, C40-C49, C69-C75, C7A.098, C76-C79
  • Z85.83 Includes: Conditions classifiable to C40-C41; C45-C49

About the condition

Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.

Cancer

Cancer is not just one disease but many diseases. Cancer begins in your cells, which are the building blocks of your body. Usually, your body forms new cells as needed, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor.

Read more about cancer on MedlinePlus

Connective Tissue Disorders

Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue.

Read more about connective tissue disorders on MedlinePlus

Code history

Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.