C45-C49Not billable, use a more specific code below
Malignant neoplasms of mesothelial and soft tissue (C45-C49)
chapter 2: Neoplasms
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Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Rules for coding benign and malignant neoplasms: using the Neoplasm Table, sequencing primary and secondary sites, treatment encounters, complications, and current cancer versus personal history.
- Admission/Encounter for treatment of primary site (page 33)
- Admission/Encounter for treatment of secondary site (page 33)
- Coding and sequencing of complications (page 34)
- Primary malignancy previously excised (page 34)
- Admissions/Encounters involving antineoplastic chemotherapy, immunotherapy and radiation therapy (page 35)
- Admission/encounter to determine extent of malignancy (page 36)
- Symptoms, signs, and abnormal findings listed in Chapter 18 associated with neoplasms (page 36)
- Admission/encounter for pain control/management (page 36)
All codes under C45-C49
C45-C49 can't be used on a claim. Pick a billable code below; grey headings group them.
- C45Mesothelioma
- C45.0Mesothelioma of pleura
- C45.1Mesothelioma of peritoneum
- C45.2Mesothelioma of pericardium
- C45.7Mesothelioma of other sites
- C45.9Mesothelioma, unspecified
- C46Kaposi's sarcoma
- C46.0Kaposi's sarcoma of skin
- C46.1Kaposi's sarcoma of soft tissue
- C46.2Kaposi's sarcoma of palate
- C46.3Kaposi's sarcoma of lymph nodes
- C46.4Kaposi's sarcoma of gastrointestinal sites
- C46.5Kaposi's sarcoma of lung
- C46.50Kaposi's sarcoma of unspecified lung
- C46.51Kaposi's sarcoma of right lung
- C46.52Kaposi's sarcoma of left lung
- C46.7Kaposi's sarcoma of other sites
- C46.9Kaposi's sarcoma, unspecified
- C47Malignant neoplasm of peripheral nerves and autonomic nervous system
- C47.0Malignant neoplasm of peripheral nerves of head, face and neck
- C47.1Malignant neoplasm of peripheral nerves of upper limb, including shoulder
- C47.10Malignant neoplasm of peripheral nerves of unspecified upper limb, including shoulder
- C47.11Malignant neoplasm of peripheral nerves of right upper limb, including shoulder
- C47.12Malignant neoplasm of peripheral nerves of left upper limb, including shoulder
- C47.2Malignant neoplasm of peripheral nerves of lower limb, including hip
- C47.20Malignant neoplasm of peripheral nerves of unspecified lower limb, including hip
- C47.21Malignant neoplasm of peripheral nerves of right lower limb, including hip
- C47.22Malignant neoplasm of peripheral nerves of left lower limb, including hip
- C47.3Malignant neoplasm of peripheral nerves of thorax
- C47.4Malignant neoplasm of peripheral nerves of abdomen
- C47.5Malignant neoplasm of peripheral nerves of pelvis
- C47.6Malignant neoplasm of peripheral nerves of trunk, unspecified
- C47.8Malignant neoplasm of overlapping sites of peripheral nerves and autonomic nervous system
- C47.9Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified
- C48Malignant neoplasm of retroperitoneum and peritoneum
- C48.0Malignant neoplasm of retroperitoneum
- C48.1Malignant neoplasm of specified parts of peritoneum
- C48.2Malignant neoplasm of peritoneum, unspecified
- C48.8Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum
- C49Malignant neoplasm of other connective and soft tissue
- C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
- C49.1Malignant neoplasm of connective and soft tissue of upper limb, including shoulder
- C49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
- C49.11Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
- C49.12Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
- C49.2Malignant neoplasm of connective and soft tissue of lower limb, including hip
- C49.20Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
- C49.21Malignant neoplasm of connective and soft tissue of right lower limb, including hip
- C49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip
- C49.3Malignant neoplasm of connective and soft tissue of thorax
- C49.4Malignant neoplasm of connective and soft tissue of abdomen
- C49.5Malignant neoplasm of connective and soft tissue of pelvis
- C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
- C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
- C49.9Malignant neoplasm of connective and soft tissue, unspecified
- C49.AGastrointestinal stromal tumor
- C49.A0Gastrointestinal stromal tumor, unspecified site
- C49.A1Gastrointestinal stromal tumor of esophagus
- C49.A2Gastrointestinal stromal tumor of stomach
- C49.A3Gastrointestinal stromal tumor of small intestine
- C49.A4Gastrointestinal stromal tumor of large intestine
- C49.A5Gastrointestinal stromal tumor of rectum
- C49.A9Gastrointestinal stromal tumor of other sites
C45-C49 MS-DRGs
This code does not group to an MS-DRG as a principal diagnosis.
Other codes that refer to C45-C49
Notes on these codes point to C45-C49.
- Z85.83 Includes: Conditions classifiable to C40-C41; C45-C49
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Mesothelioma
The tissue that lines your lungs, stomach, heart, and other organs is called mesothelium. Mesothelioma, also known as malignant mesothelioma, is cancer of that tissue. It usually starts in the lungs, but can also start in the abdomen or other organs.
Read more about mesothelioma on MedlinePlus