Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R77.0|

    Abnormality of albumin

  • R77.1|

    Abnormality of globulin

  • R77.2|

    Abnormality of alphafetoprotein

  • R77.8|

    Other specified abnormalities of plasma proteins

  • R77.9|

    Abnormality of plasma protein, unspecified

  • R78|

    Findings of drugs and other substances, not normally found in blood

  • R78.0|

    Finding of alcohol in blood

  • R78.1|

    Finding of opiate drug in blood

  • R78.2|

    Finding of cocaine in blood

  • R78.3|

    Finding of hallucinogen in blood

  • R78.4|

    Finding of other drugs of addictive potential in blood

  • R78.5|

    Finding of other psychotropic drug in blood

  • R78.6|

    Finding of steroid agent in blood

  • R78.7|

    Finding of abnormal level of heavy metals in blood

  • R78.71|

    Abnormal lead level in blood

  • R78.79|

    Finding of abnormal level of heavy metals in blood

  • R78.8|

    Finding of other specified substances, not normally found in blood

  • R78.81|

    Bacteremia

  • R78.89|

    Finding of other specified substances, not normally found in blood

  • R78.9|

    Finding of unspecified substance, not normally found in blood

  • R79|

    Other abnormal findings of blood chemistry

  • R79.0|

    Abnormal level of blood mineral

  • R79.1|

    Abnormal coagulation profile

  • R79.8|

    Other specified abnormal findings of blood chemistry

  • R79.81|

    Abnormal blood-gas level

  • R79.82|

    Elevated C-reactive protein (CRP)

  • R79.83|

    Abnormal findings of blood amino-acid level

  • R79.89|

    Other specified abnormal findings of blood chemistry

  • R79.9|

    Abnormal finding of blood chemistry, unspecified

  • R80|

    Proteinuria

  • R80.0|

    Isolated proteinuria

  • R80.1|

    Persistent proteinuria, unspecified

  • R80.2|

    Orthostatic proteinuria, unspecified

  • R80.3|

    Bence Jones proteinuria

  • R80.8|

    Other proteinuria

  • R80.9|

    Proteinuria, unspecified

  • R81|

    Glycosuria

  • R82|

    Other and unspecified abnormal findings in urine

  • R82.0|

    Chyluria

  • R82.1|

    Myoglobinuria

  • R82.2|

    Biliuria

  • R82.3|

    Hemoglobinuria

  • R82.4|

    Acetonuria

  • R82.5|

    Elevated urine levels of drugs, medicaments and biological substances

  • R82.6|

    Abnormal urine levels of substances chiefly nonmedicinal as to source

  • R82.7|

    Abnormal findings on microbiological examination of urine

  • R82.71|

    Bacteriuria

  • R82.79|

    Other abnormal findings on microbiological examination of urine

  • R82.8|

    Abnormal findings on cytological and histological examination of urine

  • R82.81|

    Pyuria

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