Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R77.0

    Abnormality of albumin

  • R77.1

    Abnormality of globulin

  • R77.2

    Abnormality of alphafetoprotein

  • R77.8

    Other specified abnormalities of plasma proteins

  • R77.9

    Abnormality of plasma protein, unspecified

  • R78

    Findings of drugs and other substances, not normally found in blood

  • R78.0

    Finding of alcohol in blood

  • R78.1

    Finding of opiate drug in blood

  • R78.2

    Finding of cocaine in blood

  • R78.3

    Finding of hallucinogen in blood

  • R78.4

    Finding of other drugs of addictive potential in blood

  • R78.5

    Finding of other psychotropic drug in blood

  • R78.6

    Finding of steroid agent in blood

  • R78.7

    Finding of abnormal level of heavy metals in blood

  • R78.71

    Abnormal lead level in blood

  • R78.79

    Finding of abnormal level of heavy metals in blood

  • R78.8

    Finding of other specified substances, not normally found in blood

  • R78.81

    Bacteremia

  • R78.89

    Finding of other specified substances, not normally found in blood

  • R78.9

    Finding of unspecified substance, not normally found in blood

  • R79

    Other abnormal findings of blood chemistry

  • R79.0

    Abnormal level of blood mineral

  • R79.1

    Abnormal coagulation profile

  • R79.8

    Other specified abnormal findings of blood chemistry

  • R79.81

    Abnormal blood-gas level

  • R79.82

    Elevated C-reactive protein (CRP)

  • R79.83

    Abnormal findings of blood amino-acid level

  • R79.89

    Other specified abnormal findings of blood chemistry

  • R79.9

    Abnormal finding of blood chemistry, unspecified

  • R80

    Proteinuria

  • R80.0

    Isolated proteinuria

  • R80.1

    Persistent proteinuria, unspecified

  • R80.2

    Orthostatic proteinuria, unspecified

  • R80.3

    Bence Jones proteinuria

  • R80.8

    Other proteinuria

  • R80.9

    Proteinuria, unspecified

  • R81

    Glycosuria

  • R82

    Other and unspecified abnormal findings in urine

  • R82.0

    Chyluria

  • R82.1

    Myoglobinuria

  • R82.2

    Biliuria

  • R82.3

    Hemoglobinuria

  • R82.4

    Acetonuria

  • R82.5

    Elevated urine levels of drugs, medicaments and biological substances

  • R82.6

    Abnormal urine levels of substances chiefly nonmedicinal as to source

  • R82.7

    Abnormal findings on microbiological examination of urine

  • R82.71

    Bacteriuria

  • R82.79

    Other abnormal findings on microbiological examination of urine

  • R82.8

    Abnormal findings on cytological and histological examination of urine

  • R82.81

    Pyuria

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