Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R65.11

    Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

  • R65.2

    Severe sepsis

  • R65.20

    Severe sepsis without septic shock

  • R65.21

    Severe sepsis with septic shock

  • R68

    Other general symptoms and signs

  • R68.0

    Hypothermia, not associated with low environmental temperature

  • R68.1

    Nonspecific symptoms peculiar to infancy

  • R68.11

    Excessive crying of infant (baby)

  • R68.12

    Fussy infant (baby)

  • R68.13

    Apparent life threatening event in infant (ALTE)

  • R68.19

    Other nonspecific symptoms peculiar to infancy

  • R68.2

    Dry mouth, unspecified

  • R68.3

    Clubbing of fingers

  • R68.8

    Other general symptoms and signs

  • R68.81

    Early satiety

  • R68.82

    Decreased libido

  • R68.83

    Chills (without fever)

  • R68.84

    Jaw pain

  • R68.89

    Other general symptoms and signs

  • R69

    Illness, unspecified

  • R70

    Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity

  • R70.0

    Elevated erythrocyte sedimentation rate

  • R70.1

    Abnormal plasma viscosity

  • R71

    Abnormality of red blood cells

  • R71.0

    Precipitous drop in hematocrit

  • R71.8

    Other abnormality of red blood cells

  • R73

    Elevated blood glucose level

  • R73.0

    Abnormal glucose

  • R73.01

    Impaired fasting glucose

  • R73.02

    Impaired glucose tolerance (oral)

  • R73.03

    Prediabetes

  • R73.09

    Other abnormal glucose

  • R73.9

    Hyperglycemia, unspecified

  • R74

    Abnormal serum enzyme levels

  • R74.0

    Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]

  • R74.01

    Elevation of levels of liver transaminase levels

  • R74.02

    Elevation of levels of lactic acid dehydrogenase [LDH]

  • R74.8

    Abnormal levels of other serum enzymes

  • R74.9

    Abnormal serum enzyme level, unspecified

  • R75

    Inconclusive laboratory evidence of human immunodeficiency virus [HIV]

  • R76

    Other abnormal immunological findings in serum

  • R76.0

    Raised antibody titer

  • R76.1

    Nonspecific reaction to test for tuberculosis

  • R76.11

    Nonspecific reaction to tuberculin skin test without active tuberculosis

  • R76.12

    Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis

  • R76.8

    Other specified abnormal immunological findings in serum

  • R76.81

    Abnormal rheumatoid factor and anti-citrullinated protein antibody without rheumatoid arthritis

  • R76.89

    Other specified abnormal immunological findings in serum

  • R76.9

    Abnormal immunological finding in serum, unspecified

  • R77

    Other abnormalities of plasma proteins

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