Disorders of porphyrin and bilirubin metabolism
In Metabolic disorders (E70-E88), chapter 4: Endocrine, Nutritional and Metabolic Diseases
10 billable codes under E80: 6 are a CC; 6 map to HCC 50 (Amyloidosis, Porphyria, and Other Specified Metabolic Disorders).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Instructional notes
Includes: conditions that are coded here
- defects of catalase and peroxidase
Also applies, from Metabolic disorders (E70-E88)
These notes sit on E70-E88 and apply to every code under it, including E80.
Excludes1: not coded here, use a different code
Excludes2: not included here, code separately if applicable
- Ehlers-Danlos syndromes (Q79.6-)
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Covers diabetes mellitus coding, including type, insulin and drug use, pump malfunction and secondary diabetes, plus obesity and obesity class codes.
- Diabetes mellitus (page 39)
- Obesity (page 42)
All codes under E80
E80 can't be used on a claim. Pick a billable code below; grey headings group them.
- E80.0Hereditary erythropoietic porphyria
- E80.1Porphyria cutanea tarda
- E80.2Other and unspecified porphyria
- E80.20Unspecified porphyria
- E80.21Acute intermittent (hepatic) porphyria
- E80.29Other porphyria
- E80.3Defects of catalase and peroxidase
- E80.4Gilbert syndrome
- E80.5Crigler-Najjar syndrome
- E80.6Other disorders of bilirubin metabolism
- E80.7Disorder of bilirubin metabolism, unspecified
E80 MS-DRGs
As the principal diagnosis, the billable codes under E80 group to MS-DRG 642, 441, 442, or 443 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 642 Inborn and Other Disorders of Metabolism (6 of 10 codes)
- DRG 441 Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with MCC (4 of 10 codes)
- DRG 442 Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with CC (4 of 10 codes)
- DRG 443 Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis without CC/MCC (4 of 10 codes)
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Metabolic Disorders
Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.
Read more about metabolic disorders on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
