Nondiabetic hypoglycemic coma
In Other disorders of glucose regulation and pancreatic internal secretion (E15-E16), chapter 4: Endocrine, Nutritional and Metabolic Diseases
- E15 is billable and valid on claims for FY 2027. If the record has more detail, check the other codes under E15-E16 below.
- As a secondary diagnosis it is a CC (complication or comorbidity), which can raise the MS-DRG payment. It doesn't count when the principal diagnosis is one of 355 closely related codes.
- Doesn't count toward a Medicare Advantage risk score (no HCC in V28; it was HCC 23 in V24).
- AHRQ's Chronic Condition Indicator classes it as not chronic (an acute or short-term condition).
- 15 US deaths in 2024 had an underlying cause in category E15, per the National Vital Statistics System on CDC WONDER. Death records use WHO ICD-10, so the count is for the whole category.
Also indexed as: Coma, hypoglycemic, nondiabetic; Hyperinsulinism, with, coma; Hypoglycemia, coma; Hypoglycemia, drug-induced, with coma; Hypoglycemia, due to insulin, with coma; Hypoglycemia, iatrogenic, with coma; Reaction, hypoglycemic, due to insulin, with coma, nondiabetic; Shock, insulin
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Instructional notes
Includes: conditions that are coded here
- drug-induced insulin coma in nondiabetic
- hyperinsulinism with hypoglycemic coma
- hypoglycemic coma NOS
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Covers diabetes mellitus coding, including type, insulin and drug use, pump malfunction and secondary diabetes, plus obesity and obesity class codes.
- Diabetes mellitus (page 39)
- Obesity (page 42)
Other codes under E15-E16
Other disorders of glucose regulation and pancreatic internal secretion (E15-E16)
- E15Nondiabetic hypoglycemic coma(this code)
- E16Other disorders of pancreatic internal secretion
E15 MS-DRGs
As the principal diagnosis, E15 groups to MS-DRG 640, 641, 791, or 793 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
Related conditions
Grouped by AHRQ's Clinical Classifications Software Refined (CCSR), which sorts every diagnosis code into clinically meaningful categories.
E15 is in Other specified and unspecified endocrine disorders (END015, its default category), with 101 codes. Others in it:
E15 is in Coma; stupor; and brain damage (NVS013), with 34 codes. Others in it:
- B15.0 Hepatitis A with hepatic coma
- B16.0 Acute hepatitis B with delta-agent with hepatic coma
- B16.2 Acute hepatitis B without delta-agent with hepatic coma
- B17.11 Acute hepatitis C with hepatic coma
- B19.0 Unspecified viral hepatitis with hepatic coma
- B19.11 Unspecified viral hepatitis B with hepatic coma
- B19.21 Unspecified viral hepatitis C with hepatic coma
- E03.5 Myxedema coma
Medicare coverage articles listing E15
These 3 Medicare billing and coding articles list E15 as a diagnosis that supports medical necessity for the services they cover. From the CMS Medicare Coverage Database; check your own contractor's article before billing.
Other codes that refer to E15
Notes on these codes point to E15.
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Coma
A coma is a deep state of unconsciousness. An individual in a coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as brain injury.
Read more about coma on MedlinePlusHypoglycemia
Blood glucose, or blood sugar, is the main sugar found in your blood. It is your body's primary source of energy. It comes from the food you eat. Your body breaks down most of that food into glucose and releases it into your bloodstream. When your blood glucose goes up, it signals your pancreas to release insulin. Insulin is a hormone that helps the glucose get into your cells to be used for energy.
Read more about hypoglycemia on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
ICD-9-CM equivalent
Legacy crosswalk from the CMS General Equivalence Mappings (last updated 2018).
- 251.0 Hypoglycemic coma