All ICD10 Codes
Chapter 3

D50–D89: Diseases of the Blood and Blood-Forming Organs

Diseases of the Blood and Blood-Forming Organs diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
All CodesBillable Only
Internal Codes
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  • D89.1—

    Cryoglobulinemia

  • D89.2—

    Hypergammaglobulinemia, unspecified

  • D89.3—

    Immune reconstitution syndrome

  • D89.40—

    Mast cell activation, unspecified

  • D89.41—

    Monoclonal mast cell activation syndrome

  • D89.42—

    Idiopathic mast cell activation syndrome

  • D89.43—

    Secondary mast cell activation

  • D89.44—

    Hereditary alpha tryptasemia

  • D89.49—

    Other mast cell activation disorder

  • D89.810—

    Acute graft-versus-host disease

  • D89.811—

    Chronic graft-versus-host disease

  • D89.812—

    Acute on chronic graft-versus-host disease

  • D89.813—

    Graft-versus-host disease, unspecified

  • D89.82—

    Autoimmune lymphoproliferative syndrome [ALPS]

  • D89.831—

    Cytokine release syndrome, grade 1

  • D89.832—

    Cytokine release syndrome, grade 2

  • D89.833—

    Cytokine release syndrome, grade 3

  • D89.834—

    Cytokine release syndrome, grade 4

  • D89.835—

    Cytokine release syndrome, grade 5

  • D89.839—

    Cytokine release syndrome, grade unspecified

  • D89.84—

    IgG4-related disease

  • D89.89—

    Other specified disorders involving the immune mechanism, not elsewhere classified

  • D89.9—

    Disorder involving the immune mechanism, unspecified

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