Chapter 3

D50–D89: Diseases of the Blood and Blood-Forming Organs

Diseases of the Blood and Blood-Forming Organs diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

All Codes Billable Only

Internal Codes

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D73.1|
Hypersplenism
D73.2|
Chronic congestive splenomegaly
D73.3|
Abscess of spleen
D73.4|
Cyst of spleen
D73.5|
Infarction of spleen
D73.81|
Neutropenic splenomegaly
D73.89|
Other diseases of spleen
D73.9|
Disease of spleen, unspecified
D74.0|
Congenital methemoglobinemia
D74.8|
Other methemoglobinemias
D74.9|
Methemoglobinemia, unspecified
D75.0|
Familial erythrocytosis
D75.1|
Secondary polycythemia
D75.81|
Myelofibrosis
D75.821|
Non-immune heparin-induced thrombocytopenia
D75.822|
Immune-mediated heparin-induced thrombocytopenia
D75.828|
Other heparin-induced thrombocytopenia syndrome
D75.829|
Heparin-induced thrombocytopenia, unspecified
D75.838|
Other thrombocytosis
D75.839|
Thrombocytosis, unspecified
D75.84|
Other platelet-activating anti-PF4 disorders
D75.89|
Other specified diseases of blood and blood-forming organs
D75.9|
Disease of blood and blood-forming organs, unspecified
D75.A|
Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia
D76.1|
Hemophagocytic lymphohistiocytosis
D76.2|
Hemophagocytic syndrome, infection-associated
D76.3|
Other histiocytosis syndromes
D77|
Other disorders of blood and blood-forming organs in diseases classified elsewhere
D78.01|
Intraoperative hemorrhage and hematoma of the spleen complicating a procedure on the spleen
D78.02|
Intraoperative hemorrhage and hematoma of the spleen complicating other procedure
D78.11|
Accidental puncture and laceration of the spleen during a procedure on the spleen
D78.12|
Accidental puncture and laceration of the spleen during other procedure
D78.21|
Postprocedural hemorrhage of the spleen following a procedure on the spleen
D78.22|
Postprocedural hemorrhage of the spleen following other procedure
D78.31|
Postprocedural hematoma of the spleen following a procedure on the spleen
D78.32|
Postprocedural hematoma of the spleen following other procedure
D78.33|
Postprocedural seroma of the spleen following a procedure on the spleen
D78.34|
Postprocedural seroma of the spleen following other procedure
D78.81|
Other intraoperative complications of the spleen
D78.89|
Other postprocedural complications of the spleen
D80.0|
Hereditary hypogammaglobulinemia
D80.1|
Nonfamilial hypogammaglobulinemia
D80.2|
Selective deficiency of immunoglobulin A [IgA]
D80.3|
Selective deficiency of immunoglobulin G [IgG] subclasses
D80.4|
Selective deficiency of immunoglobulin M [IgM]
D80.5|
Immunodeficiency with increased immunoglobulin M [IgM]
D80.6|
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D80.7|
Transient hypogammaglobulinemia of infancy
D80.8|
Other immunodeficiencies with predominantly antibody defects
D80.9|
Immunodeficiency with predominantly antibody defects, unspecified

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