D81.82

Billable
ChapterD50–D89
Ranksubcategory
Official Description

Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

Metadata & Insights
  • •2026 ICD-10-CM Edition - Effective October 1, 2025.
  • •Billable/specific code (valid for reimbursement).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

Instructional Notes

Includes
  • p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease
Code Also
  • , if applicable, any associated manifestations, such as:
  • bronchiectasis (J47.-)
  • herpes virus infections (B00.-)
  • other acute respiratory tract infections (J00-J06; J20-J22)
  • other infections (A00-B99)
  • pneumonia (J12-J18)
General instructions are available for the parent sections:
View CH3 NotesView D80-D89 NotesView D81 Notes

Clinical Hierarchy

CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D80-D89Certain disorders involving the immune mechanism (D80-D89)
D81Combined immunodeficiencies
D81.8Other combined immunodeficiencies
D81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D81.82:

categoryD81
Combined immunodeficiencies
View context instructions
blockD80-D89
Certain disorders involving the immune mechanism (D80-D89)
View context instructions
chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to D81.82. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

2 raw paths
Disease, diseased1 unique routes
p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI]→D81.82
Syndrome1 unique routes
activated phosphoinositide 3-kinase delta syndrome [APDS]→D81.82

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 808
Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with MCC
DRG 809
Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders with CC
DRG 810
Major Hematological and Immunological Diagnoses Except Sickle Cell Crisis and Coagulation Disorders without CC/MCC

Cross Reference

Find Procedures (ICD-10-PCS)

Find surgical and procedural codes related to Activated Phosphoinositide 3-kinase Delta Syndrome [APDS].

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