Chapter 21

Z00–Z99: Factors Influencing Health Status and Contact with Health Services

Factors Influencing Health Status and Contact with Health Services diagnostic classification updated for 2026.

Internal Codes
  • Z16.341

    Resistance to single antimycobacterial drug

  • Z16.342

    Resistance to multiple antimycobacterial drugs

  • Z16.35

    Resistance to multiple antimicrobial drugs

  • Z16.39

    Resistance to other specified antimicrobial drug

  • Z17

    Estrogen, and other hormones and factors receptor status

  • Z17.0

    Estrogen receptor positive status [ER+]

  • Z17.1

    Estrogen receptor negative status [ER-]

  • Z17.2

    Progesterone receptor status

  • Z17.21

    Progesterone receptor positive status

  • Z17.22

    Progesterone receptor negative status

  • Z17.3

    Human epidermal growth factor 2 receptor

  • Z17.31

    Human epidermal growth factor receptor 2 positive status

  • Z17.32

    Human epidermal growth factor receptor 2 negative status

  • Z17.4

    Combined receptor status

  • Z17.41

    Hormone receptor positive

  • Z17.410

    Hormone receptor positive with human epidermal growth factor receptor 2 positive status

  • Z17.411

    Hormone receptor positive with human epidermal growth factor receptor 2 negative status

  • Z17.42

    Hormone receptor negative

  • Z17.420

    Hormone receptor negative with human epidermal growth factor receptor 2 positive status

  • Z17.421

    Hormone receptor negative with human epidermal growth factor receptor 2 negative status

  • Z18

    Retained foreign body fragments

  • Z18.0

    Retained radioactive fragments

  • Z18.01

    Retained depleted uranium fragments

  • Z18.09

    Other retained radioactive fragments

  • Z18.1

    Retained metal fragments

  • Z18.10

    Retained metal fragments, unspecified

  • Z18.11

    Retained magnetic metal fragments

  • Z18.12

    Retained nonmagnetic metal fragments

  • Z18.2

    Retained plastic fragments

  • Z18.3

    Retained organic fragments

  • Z18.31

    Retained animal quills or spines

  • Z18.32

    Retained tooth

  • Z18.33

    Retained wood fragments

  • Z18.39

    Other retained organic fragments

  • Z18.8

    Other specified retained foreign body

  • Z18.81

    Retained glass fragments

  • Z18.83

    Retained stone or crystalline fragments

  • Z18.89

    Other specified retained foreign body fragments

  • Z18.9

    Retained foreign body fragments, unspecified material

  • Z19

    Hormone sensitivity malignancy status

  • Z19.1

    Hormone sensitive malignancy status

  • Z19.2

    Hormone resistant malignancy status

  • Z20

    Contact with and (suspected) exposure to communicable diseases

  • Z20.0

    Contact with and (suspected) exposure to intestinal infectious diseases

  • Z20.01

    Contact with and (suspected) exposure to intestinal infectious diseases due to Escherichia coli (E. coli)

  • Z20.09

    Contact with and (suspected) exposure to other intestinal infectious diseases

  • Z20.1

    Contact with and (suspected) exposure to tuberculosis

  • Z20.2

    Contact with and (suspected) exposure to infections with a predominantly sexual mode of transmission

  • Z20.3

    Contact with and (suspected) exposure to rabies

  • Z20.4

    Contact with and (suspected) exposure to rubella

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