Estrogen, and other hormones and factors receptor status
chapter 21: Factors Influencing Health Status and Contact with Health Services
10 billable codes under Z17: none are a CC or MCC; none map to an HCC.
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Instructional notes
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Covers when and how to use Z codes (Z00-Z99) for encounters and supplementary information, including contact, status, history, screening, aftercare, exams, and social determinants of health.
All codes under Z17
Z17 can't be used on a claim. Pick a billable code below; grey headings group them.
- Z17.0Estrogen receptor positive status [ER+]
- Z17.1Estrogen receptor negative status [ER-]
- Z17.2Progesterone receptor status
- Z17.21Progesterone receptor positive status
- Z17.22Progesterone receptor negative status
- Z17.3Human epidermal growth factor 2 receptor
- Z17.31Human epidermal growth factor receptor 2 positive status
- Z17.32Human epidermal growth factor receptor 2 negative status
- Z17.4Combined receptor status
- Z17.41Hormone receptor positive
- Z17.410Hormone receptor positive with human epidermal growth factor receptor 2 positive status
- Z17.411Hormone receptor positive with human epidermal growth factor receptor 2 negative status
- Z17.42Hormone receptor negative
- Z17.420Hormone receptor negative with human epidermal growth factor receptor 2 positive status
- Z17.421Hormone receptor negative with human epidermal growth factor receptor 2 negative status
Z17 MS-DRGs
As the principal diagnosis, the billable codes under Z17 group to MS-DRG 951, 947, or 948 (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 951 Other Factors Influencing Health Status (8 of 10 codes)
- DRG 947 Signs and Symptoms with MCC (2 of 10 codes)
- DRG 948 Signs and Symptoms without MCC (2 of 10 codes)
Other codes that refer to Z17
Notes on these codes point to Z17.
- C50 Use Additional Code: code to identify estrogen, and other hormones and factors receptor status (Z17.-)
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Breast Cancer
Breast cancer is a cancer that starts in breast tissue. It happens when cells in the breast change and grow out of control. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor.
Read more about breast cancer on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015.
- FY2025: Title changed. It was: Estrogen receptor status.