F59Billable, valid for claims from October 1, 2026

Unspecified behavioral syndromes associated with physiological disturbances and physical factors

In Behavioral syndromes associated with physiological disturbances and physical factors (F50-F59), chapter 5: Mental, Behavioral and Neurodevelopmental Disorders

  • F59 is an unspecified code: use it only when the record doesn't document anything more specific. If the record has more detail, check the other codes under F50-F59 below.
  • As a secondary diagnosis it is not a CC or MCC, so it doesn't raise the MS-DRG payment.
  • Doesn't count toward a Medicare Advantage risk score (no HCC in V28).
  • AHRQ's Chronic Condition Indicator classes it as not chronic (an acute or short-term condition).

Also indexed as: Dysfunction, physiological NEC, psychogenic; Dysfunction, psychophysiologic; Psychological and behavioral factors affecting medical condition

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Instructional notes

Includes: conditions that are coded here

  • Psychogenic physiological dysfunction NOS

Official coding guidelines

From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.

Covers psychological pain disorders, substance use, abuse, dependence and remission, factitious disorder including Munchausen by proxy, and dementia severity.

Read Section I.C.5 (page 43)

F59 MS-DRG

As the principal diagnosis, F59 groups to MS-DRG 887 (v44.0).

Related conditions

Grouped by AHRQ's Clinical Classifications Software Refined (CCSR), which sorts every diagnosis code into clinically meaningful categories.

F59 is in Miscellaneous mental and behavioral disorders/conditions (MBD013, its default category), with 53 codes. Others in it:

  • F06.8 Other specified mental disorders due to known physiological condition
  • F07.9 Unspecified personality and behavioral disorder due to known physiological condition
  • F09 Unspecified mental disorder due to known physiological condition
  • F48.8 Other specified nonpsychotic mental disorders
  • F48.9 Nonpsychotic mental disorder, unspecified
  • F52.0 Hypoactive sexual desire disorder
  • F52.1 Sexual aversion disorder
  • F52.21 Male erectile disorder

Medicare coverage articles listing F59

These 5 Medicare billing and coding articles list F59 as a diagnosis that supports medical necessity for the services they cover. From the CMS Medicare Coverage Database; check your own contractor's article before billing.

Other codes that refer to F59

Notes on these codes point to F59.

  • Z86.5 Includes: Conditions classifiable to F40-F59

About the condition

Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.

Mental Disorders

Mental disorders (or mental illnesses) are conditions that affect your thinking, feeling, mood, and behavior. They may happen over a short period of time or come and go. Some can be chronic (long-lasting). They can affect your ability to relate to others and function each day..

Read more about mental disorders on MedlinePlus

Code history

Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.

ICD-9-CM equivalent

Legacy crosswalk from the CMS General Equivalence Mappings (last updated 2018).

  • 306.8 Other specified psychophysiological malfunction (approximate)
ICD-9 to ICD-10 converter