Chapter 4

E00–E89: Endocrine, Nutritional and Metabolic Diseases

Endocrine, Nutritional and Metabolic Diseases diagnostic classification updated for 2026.

Chapter Instructions

Excludes1(Not coded here. Use a different code.)
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Internal Codes
  • E27.1

    Primary adrenocortical insufficiency

  • E27.2

    Addisonian crisis

  • E27.3

    Drug-induced adrenocortical insufficiency

  • E27.40

    Unspecified adrenocortical insufficiency

  • E27.49

    Other adrenocortical insufficiency

  • E27.5

    Adrenomedullary hyperfunction

  • E27.8

    Other specified disorders of adrenal gland

  • E27.9

    Disorder of adrenal gland, unspecified

  • E28.0

    Estrogen excess

  • E28.1

    Androgen excess

  • E28.2

    Polycystic ovarian syndrome

  • E28.310

    Symptomatic premature menopause

  • E28.319

    Asymptomatic premature menopause

  • E28.39

    Other primary ovarian failure

  • E28.8

    Other ovarian dysfunction

  • E28.9

    Ovarian dysfunction, unspecified

  • E29.0

    Testicular hyperfunction

  • E29.1

    Testicular hypofunction

  • E29.8

    Other testicular dysfunction

  • E29.9

    Testicular dysfunction, unspecified

  • E30.0

    Delayed puberty

  • E30.1

    Precocious puberty

  • E30.8

    Other disorders of puberty

  • E30.9

    Disorder of puberty, unspecified

  • E31.0

    Autoimmune polyglandular failure

  • E31.1

    Polyglandular hyperfunction

  • E31.20

    Multiple endocrine neoplasia [MEN] syndrome, unspecified

  • E31.21

    Multiple endocrine neoplasia [MEN] type I

  • E31.22

    Multiple endocrine neoplasia [MEN] type IIA

  • E31.23

    Multiple endocrine neoplasia [MEN] type IIB

  • E31.8

    Other polyglandular dysfunction

  • E31.9

    Polyglandular dysfunction, unspecified

  • E32.0

    Persistent hyperplasia of thymus

  • E32.1

    Abscess of thymus

  • E32.8

    Other diseases of thymus

  • E32.9

    Disease of thymus, unspecified

  • E34.00

    Carcinoid syndrome, unspecified

  • E34.01

    Carcinoid heart syndrome

  • E34.09

    Other carcinoid syndrome

  • E34.1

    Other hypersecretion of intestinal hormones

  • E34.2

    Ectopic hormone secretion, not elsewhere classified

  • E34.30

    Short stature due to endocrine disorder, unspecified

  • E34.31

    Constitutional short stature

  • E34.321

    Primary insulin-like growth factor-1 (IGF-1) deficiency

  • E34.322

    Insulin-like growth factor-1 (IGF-1) resistance

  • E34.328

    Other genetic causes of short stature

  • E34.329

    Unspecified genetic causes of short stature

  • E34.39

    Other short stature due to endocrine disorder

  • E34.4

    Constitutional tall stature

  • E34.50

    Androgen insensitivity syndrome, unspecified

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