All ICD10 Codes

E85.4

Billable
ChapterE00–E89
Ranksubcategory
Official Description

Organ-limited amyloidosis

Metadata & Insights
  • •2026 ICD-10-CM Edition - Effective October 1, 2025.
  • •Billable/specific code (valid for reimbursement).
  • •Chapter 4: Endocrine, Nutritional and Metabolic Diseases (E00-E89).

Instructional Notes

Includes
  • Localized amyloidosis
  • Transthyretin-related (ATTR) familial amyloid cardiomyopathy
General instructions are available for the parent sections:
View CH4 NotesView E70-E88 NotesView E85 Notes

Clinical Hierarchy

CH4Endocrine, nutritional and metabolic diseases (E00-E89)
E70-E88Metabolic disorders (E70-E88)
E85Amyloidosis
E85.4Organ-limited amyloidosis

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to E85.4:

categoryE85
Amyloidosis
View context instructions
blockE70-E88
Metabolic disorders (E70-E88)
View context instructions
chapterCH4
Endocrine, nutritional and metabolic diseases (E00-E89)
View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to E85.4. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

25 raw paths
Amyloid heart (disease)1 unique routes
Direct index entry→E85.4
Amyloidosis (generalized) (primary)8 unique routes
heart→E85.4
liver→E85.4
localized→E85.4
organ limited→E85.4
pulmonary→E85.4
skin (lichen) (macular)→E85.4
subglottic→E85.4
with lung involvement→E85.4
Angiopathia, angiopathy1 unique routes
cerebral
amyloid→E85.4
Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute)1 unique routes
in (due to)
amyloidosis→E85.4
Arthropathy1 unique routes
in (due to)
amyloidosis→E85.4
Cardiomyopathy (familial) (idiopathic)3 unique routes
amyloid→E85.4(2 variants)
transthyretin-related (ATTR) familial→E85.4
transthyretin-related (ATTR) familial amyloid→E85.4
Degeneration, degenerative10 unique routes
artery, arterial (atheromatous) (calcareous)
cerebral, amyloid→E85.4
cutis
amyloid→E85.4
heart
amyloid→E85.4
intestine, amyloid→E85.4
kidney
amyloid→E85.4
liver (diffuse) NEC
amyloid→E85.4
nervous system
amyloid→E85.4
skin
amyloid→E85.4
spinal (cord)
amyloid→E85.4
spleen
amyloid→E85.4

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 545
Connective Tissue Disorders with MCC
DRG 546
Connective Tissue Disorders with CC
DRG 547
Connective Tissue Disorders without CC/MCC

Cross Reference

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