D75.81

Billable
ChapterD50–D89
Ranksubcategory
Official Description

Myelofibrosis

Metadata & Insights
  • •2026 ICD-10-CM Edition - Effective October 1, 2025.
  • •Billable/specific code (valid for reimbursement).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

Instructional Notes

Includes
  • Myelofibrosis NOS
  • Secondary myelofibrosis NOS
Excludes1(Not coded here)
  • acute myelofibrosis (C94.4-)
  • idiopathic myelofibrosis (D47.1)
  • leukoerythroblastic anemia (D61.82)
  • myelofibrosis with myeloid metaplasia (D47.4)
  • myelophthisic anemia (D61.82)
  • myelophthisis (D61.82)
  • primary myelofibrosis (D47.1)
Code First
  • the underlying disorder, such as:
  • malignant neoplasm of breast (C50.-)
Use Additional Code
  • code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
  • code for adverse effect, if applicable, to identify drug (T45.1X5)
General instructions are available for the parent sections:
View CH3 NotesView D75 Notes

Clinical Hierarchy

CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D70-D77Other disorders of blood and blood-forming organs (D70-D77)
D75Other and unspecified diseases of blood and blood-forming organs
D75.8Other specified diseases of blood and blood-forming organs
D75.81Myelofibrosis

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D75.81:

categoryD75
Other and unspecified diseases of blood and blood-forming organs
View context instructions
chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to D75.81. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

4 raw paths
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)1 unique routes
myelofibrosis→D75.81
Myelofibrosis2 unique routes
Direct index entry→D75.81
secondary→D75.81
Osteosclerosis1 unique routes
myelofibrosis→D75.81

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 820
Lymphoma and Leukemia with Major O.R. Procedures with MCC
DRG 821
Lymphoma and Leukemia with Major O.R. Procedures with CC
DRG 822
Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC
DRG 823
Lymphoma and Non-Acute Leukemia with Other Procedures with MCC
DRG 824
Lymphoma and Non-Acute Leukemia with Other Procedures with CC
DRG 825
Lymphoma and Non-Acute Leukemia with Other Procedures without CC/MCC
DRG 840
Lymphoma and Non-Acute Leukemia with MCC
DRG 841
Lymphoma and Non-Acute Leukemia with CC
DRG 842
Lymphoma and Non-Acute Leukemia without CC/MCC

Cross Reference

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