D57

Non-Billable
ChapterD50–D89
Rankcategory
Official Description

Sickle-cell disorders

Metadata & Insights
  • •2026 ICD-10-CM Edition - Effective October 1, 2025.
  • •Non-billable category (requires more specific sub-code).
  • •Chapter 3: Diseases of the Blood and Blood-Forming Organs (D50-D89).

CH3 Parent Instructions

Excludes2(Not included here)
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Instructional Notes

Excludes1(Not coded here)
  • other hemoglobinopathies (D58.-)
Use Additional Code
  • code for any associated fever (R50.81)

Clinical Hierarchy

CH3Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
D55-D59Hemolytic anemias (D55-D59)
D57Sickle-cell disorders
D57.0Hb-SS disease with crisis
D57.1Sickle-cell disease without crisis
D57.2Sickle-cell/Hb-C disease
D57.3Sickle-cell trait
D57.4Sickle-cell thalassemia
D57.8Other sickle-cell disorders

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to D57:

chapterCH3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
View context instructions

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to D57. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

25 raw paths
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)2 unique routes
Herrick's→D57
microdrepanocytosis→D57
Arthropathy1 unique routes
gouty
in (due to)
sickle-cell disorders→D57
Crisis6 unique routes
sickle-cell→D57(6 variants)
with(5 variants)
acute chest syndrome→D57
cerebral vascular involvement→D57
complication specified NEC→D57
pain (vaso-occlusive)→D57
splenic sequestration→D57
Dactylitis9 unique routes
sickle-cell→D57(9 variants)
Beta plus→D57
Beta zero→D57
Hb C→D57
Hb SD→D57
Hb SE→D57
Hb SS→D57
specified NEC→D57
thalassemia→D57
Disease, diseased7 unique routes
hemoglobin or Hb(7 variants)
AS genotype→D57
C (Hb-C)(2 variants)
Hb-S→D57
sickle-cell→D57
S or SS→D57(4 variants)
beta plus→D57(3 variants)
with(2 variants)
acute chest syndrome→D57
cerebral vascular involvement→D57

MS-DRG Classification

2026

No direct MS-DRG triggers identified.

Cross Reference

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