Chapter 2

C00–D49: Neoplasms

Neoplasms diagnostic classification updated for 2026.

Internal Codes
  • D44.2

    Neoplasm of uncertain behavior of parathyroid gland

  • D44.3

    Neoplasm of uncertain behavior of pituitary gland

  • D44.4

    Neoplasm of uncertain behavior of craniopharyngeal duct

  • D44.5

    Neoplasm of uncertain behavior of pineal gland

  • D44.6

    Neoplasm of uncertain behavior of carotid body

  • D44.7

    Neoplasm of uncertain behavior of aortic body and other paraganglia

  • D44.9

    Neoplasm of uncertain behavior of unspecified endocrine gland

  • D45

    Polycythemia vera

  • D46

    Myelodysplastic syndromes

  • D46.0

    Refractory anemia without ring sideroblasts, so stated

  • D46.1

    Refractory anemia with ring sideroblasts

  • D46.2

    Refractory anemia with excess of blasts [RAEB]

  • D46.20

    Refractory anemia with excess of blasts, unspecified

  • D46.21

    Refractory anemia with excess of blasts 1

  • D46.22

    Refractory anemia with excess of blasts 2

  • D46.4

    Refractory anemia, unspecified

  • D46.9

    Myelodysplastic syndrome, unspecified

  • D46.A

    Refractory cytopenia with multilineage dysplasia

  • D46.B

    Refractory cytopenia with multilineage dysplasia and ring sideroblasts

  • D46.C

    Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality

  • D46.Z

    Other myelodysplastic syndromes

  • D47

    Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

  • D47.0

    Mast cell neoplasms of uncertain behavior

  • D47.01

    Cutaneous mastocytosis

  • D47.02

    Systemic mastocytosis

  • D47.09

    Other mast cell neoplasms of uncertain behavior

  • D47.1

    Chronic myeloproliferative disease

  • D47.2

    Monoclonal gammopathy

  • D47.3

    Essential (hemorrhagic) thrombocythemia

  • D47.4

    Osteomyelofibrosis

  • D47.9

    Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified

  • D47.Z

    Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

  • D47.Z1

    Post-transplant lymphoproliferative disorder (PTLD)

  • D47.Z2

    Castleman disease

  • D47.Z9

    Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

  • D48

    Neoplasm of uncertain behavior of other and unspecified sites

  • D48.0

    Neoplasm of uncertain behavior of bone and articular cartilage

  • D48.1

    Neoplasm of uncertain behavior of connective and other soft tissue

  • D48.11

    Desmoid tumor

  • D48.110

    Desmoid tumor of head and neck

  • D48.111

    Desmoid tumor of chest wall

  • D48.112

    Desmoid tumor, intrathoracic

  • D48.113

    Desmoid tumor of abdominal wall

  • D48.114

    Desmoid tumor, intraabdominal

  • D48.115

    Desmoid tumor of upper extremity and shoulder girdle

  • D48.116

    Desmoid tumor of lower extremity and pelvic girdle

  • D48.117

    Desmoid tumor of back

  • D48.118

    Desmoid tumor of other site

  • D48.119

    Desmoid tumor of unspecified site

  • D48.19

    Other specified neoplasm of uncertain behavior of connective and other soft tissue

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