Early syphilis
In Infections with a predominantly sexual mode of transmission (A50-A64), chapter 1: Certain Infectious and Parasitic Diseases
15 billable codes under A51: 1 is an MCC, 9 are a CC; none map to an HCC.A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment.
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Instructional notes
Also applies, from Infections with a predominantly sexual mode of transmission (A50-A64)
These notes sit on A50-A64 and apply to every code under it, including A51.
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
Rules for coding infections and parasitic diseases, including HIV, organism and drug resistance codes, sepsis and septic shock, MRSA, Zika, and COVID-19.
- Human Immunodeficiency Virus (HIV) Infections (page 19)
- Infectious agents as the cause of diseases classified to other chapters (page 22)
- Infections resistant to antibiotics (page 22)
- Sepsis, Severe Sepsis, and Septic Shock (page 23)
- Methicillin Resistant Staphylococcus aureus (MRSA) Conditions (page 27)
- Zika virus infections (page 28)
- Coronavirus infections (page 28)
All codes under A51
A51 can't be used on a claim. Pick a billable code below; grey headings group them.
- A51.0Primary genital syphilis
- A51.1Primary anal syphilis
- A51.2Primary syphilis of other sites
- A51.3Secondary syphilis of skin and mucous membranes
- A51.31Condyloma latum
- A51.32Syphilitic alopecia
- A51.39Other secondary syphilis of skin
- A51.4Other secondary syphilis
- A51.41Secondary syphilitic meningitis
- A51.42Secondary syphilitic female pelvic disease
- A51.43Secondary syphilitic oculopathy
- A51.44Secondary syphilitic nephritis
- A51.45Secondary syphilitic hepatitis
- A51.46Secondary syphilitic osteopathy
- A51.49Other secondary syphilitic conditions
- A51.5Early syphilis, latent
- A51.9Early syphilis, unspecified
A51 MS-DRGs
As the principal diagnosis, the billable codes under A51 group to these 28 MS-DRGs (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 867 Other Infectious and Parasitic Diseases Diagnoses with MCC (6 of 15 codes)
- DRG 868 Other Infectious and Parasitic Diseases Diagnoses with CC (6 of 15 codes)
- DRG 869 Other Infectious and Parasitic Diseases Diagnoses without CC/MCC (6 of 15 codes)
- DRG 606 Minor Skin Disorders with MCC (3 of 15 codes)
- DRG 607 Minor Skin Disorders without MCC (3 of 15 codes)
- DRG 023 Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator (1 of 15 codes)
- DRG 024 Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC (1 of 15 codes)
- DRG 097 Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC (1 of 15 codes)
- DRG 098 Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC (1 of 15 codes)
- DRG 099 Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC (1 of 15 codes)
- DRG 124 Other Disorders of the Eye with MCC or Thrombolytic Agent (1 of 15 codes)
- DRG 125 Other Disorders of the Eye without MCC (1 of 15 codes)
- DRG 393 Other Digestive System Diagnoses with MCC (1 of 15 codes)
- DRG 394 Other Digestive System Diagnoses with CC (1 of 15 codes)
- DRG 395 Other Digestive System Diagnoses without CC/MCC (1 of 15 codes)
- DRG 441 Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with MCC (1 of 15 codes)
- DRG 442 Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with CC (1 of 15 codes)
- DRG 443 Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis without CC/MCC (1 of 15 codes)
- DRG 539 Osteomyelitis with MCC (1 of 15 codes)
- DRG 540 Osteomyelitis with CC (1 of 15 codes)
- DRG 541 Osteomyelitis without CC/MCC (1 of 15 codes)
- DRG 727 Inflammation of the Male Reproductive System with MCC (1 of 15 codes)
- DRG 728 Inflammation of the Male Reproductive System without MCC (1 of 15 codes)
- DRG 742 Uterine and Adnexa Procedures for Non-Malignancy with CC/MCC (1 of 15 codes)
- DRG 743 Uterine and Adnexa Procedures for Non-Malignancy without CC/MCC (1 of 15 codes)
- DRG 757 Infections, Female Reproductive System with MCC (1 of 15 codes)
- DRG 758 Infections, Female Reproductive System with CC (1 of 15 codes)
- DRG 759 Infections, Female Reproductive System without CC/MCC (1 of 15 codes)
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Syphilis
Syphilis is a sexually transmitted infection (STI) caused by bacteria. It infects the genital area, lips, mouth, or anus of both men and women. You usually get syphilis from sexual contact with someone who has it. It can also pass from mother to baby during pregnancy.
Read more about syphilis on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
