Other sepsis
In Other bacterial diseases (A30-A49), chapter 1: Certain Infectious and Parasitic Diseases
15 billable codes under A41: all are an MCC; all map to HCC 2 (Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock).A CC or MCC (major CC) is a secondary diagnosis that raises the MS-DRG payment. An HCC counts toward a Medicare Advantage patient's risk score.
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Instructional notes
Excludes1: not coded here, use a different code
Excludes2: not included here, code separately if applicable
- sepsis (due to) (in) actinomycotic (A42.7)
- sepsis (due to) (in) anthrax (A22.7)
- sepsis (due to) (in) candidal (B37.7)
- sepsis (due to) (in) Erysipelothrix (A26.7)
- sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
- sepsis (due to) (in) gonococcal (A54.86)
- sepsis (due to) (in) herpesviral (B00.7)
- sepsis (due to) (in) listerial (A32.7)
- sepsis (due to) (in) melioidosis (A24.1)
- sepsis (due to) (in) meningococcal (A39.2-A39.4)
- sepsis (due to) (in) plague (A20.7)
- sepsis (due to) (in) tularemia (A21.7)
- toxic shock syndrome (A48.3)
Code first: code the underlying condition first, then this code
- if applicable, postprocedural sepsis (T81.44-)
- sepsis due to central venous catheter (T80.211-)
- sepsis during labor (O75.3)
- sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82)
- sepsis following immunization (T88.0-)
- sepsis following infusion, transfusion or therapeutic injection (T80.22-, T80.29-)
Official coding guidelines
From the ICD-10-CM Official Guidelines for Coding and Reporting, FY 2027 (CMS and NCHS). Links open the PDF at the right page.
- Section I.C.1.d Sepsis, Severe Sepsis, and Septic Shock (page 23), covers A41
Code the underlying systemic infection first (A41.9 if unspecified), then a code from R65.2 only when severe sepsis or related acute organ dysfunction is documented, plus organ dysfunction codes. R65.2 codes can never be principal diagnosis.
Other Chapter 1 topics:
- Human Immunodeficiency Virus (HIV) Infections (page 19)
- Infectious agents as the cause of diseases classified to other chapters (page 22)
- Infections resistant to antibiotics (page 22)
- Methicillin Resistant Staphylococcus aureus (MRSA) Conditions (page 27)
- Zika virus infections (page 28)
- Coronavirus infections (page 28)
All codes under A41
A41 can't be used on a claim. Pick a billable code below; grey headings group them.
- A41.0Sepsis due to Staphylococcus aureus
- A41.01Sepsis due to Methicillin susceptible Staphylococcus aureus
- A41.02Sepsis due to Methicillin resistant Staphylococcus aureus
- A41.1Sepsis due to other specified staphylococcus
- A41.2Sepsis due to unspecified staphylococcus
- A41.3Sepsis due to Hemophilus influenzae
- A41.4Sepsis due to anaerobes
- A41.5Sepsis due to other Gram-negative organisms
- A41.50Gram-negative sepsis, unspecified
- A41.51Sepsis due to Escherichia coli [E. coli]
- A41.52Sepsis due to Pseudomonas
- A41.53Sepsis due to Serratia
- A41.54Sepsis due to Acinetobacter baumannii
- A41.59Other Gram-negative sepsis
- A41.8Other specified sepsis
- A41.81Sepsis due to Enterococcus
- A41.89Other specified sepsis
- A41.9Sepsis, unspecified organism
A41 MS-DRGs
As the principal diagnosis, all 15 billable codes under A41 group to these 8 MS-DRGs (v44.0). Which one applies depends on procedures performed, secondary diagnoses (CC/MCC), and the patient's age and discharge status.
- DRG 791 Prematurity with Major Problems
- DRG 793 Full Term Neonate with Major Problems
- DRG 870 Septicemia or Severe Sepsis with MV >96 Hours
- DRG 871 Septicemia or Severe Sepsis without MV >96 Hours with MCC
- DRG 872 Septicemia or Severe Sepsis without MV >96 Hours without MCC
- DRG 974 HIV with Major Related Condition with MCC
- DRG 975 HIV with Major Related Condition with CC
- DRG 976 HIV with Major Related Condition without CC/MCC
Other codes that refer to A41
Notes on these codes point to A41.
- I5A Code First: sepsis (A41.-)
- J95.02 Use Additional Code: sepsis (A40, A41.-)
- K94.02 Use Additional Code: sepsis (A40.-, A41.-)
- K94.12 Use Additional Code: sepsis (A40.-, A41.-)
- K94.22 Use Additional Code: sepsis (A40.-, A41.-)
- K95.01 Use Additional Code: sepsis (A40.-, A41.-)
- K95.81 Use Additional Code: sepsis (A40.-, A41.-)
About the condition
Plain-language background from MedlinePlus (National Library of Medicine), not coding guidance.
Sepsis
Sepsis is your body's overactive and extreme response to an infection. Sepsis is a life-threatening medical emergency. Without quick treatment, it can lead to tissue damage, organ failure, and even death.
Read more about sepsis on MedlinePlusCode history
Valid since FY2016, when ICD-10-CM took effect on October 1, 2015. No changes since.
