Z16

Non-Billable

ChapterZ00–Z99

Rankcategory

Official Description

Resistance to antimicrobial drugs

Metadata & Insights

•2026 ICD-10-CM Edition - Effective October 1, 2025.
•Non-billable category (requires more specific sub-code).
•Chapter 21: Factors Influencing Health Status and Contact with Health Services (Z00-Z99).

Instructional Notes

Excludes1(Not coded here)

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code First

the infection

Clinical Hierarchy

CH21Factors influencing health status and contact with health services (Z00-Z99)

Z16Resistance to antimicrobial drugs

Z16.1Resistance to beta lactam antibiotics

Z16.2Resistance to other antibiotics

Z16.3Resistance to other antimicrobial drugs

Alphabetic Index Mentions

These are Diagnosis Index lookup paths that route to Z16. Use them as entry terms for search, then confirm final coding instructions in the Tabular List and notes above.

25 raw paths

Drug1 unique routes

resistant organism infection→Z16

Resistance, resistant (to)24 unique routes

organism (s)(24 variants)

to(24 variants)

drug→Z16(24 variants)

aminoglycosides→Z16

amoxicillin→Z16

ampicillin→Z16

antibiotic (s)→Z16(3 variants)

multiple→Z16