Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R21|

    Rash and other nonspecific skin eruption

  • R22|

    Localized swelling, mass and lump of skin and subcutaneous tissue

  • R22.0|

    Localized swelling, mass and lump, head

  • R22.1|

    Localized swelling, mass and lump, neck

  • R22.2|

    Localized swelling, mass and lump, trunk

  • R22.3|

    Localized swelling, mass and lump, upper limb

  • R22.30|

    Localized swelling, mass and lump, unspecified upper limb

  • R22.31|

    Localized swelling, mass and lump, right upper limb

  • R22.32|

    Localized swelling, mass and lump, left upper limb

  • R22.33|

    Localized swelling, mass and lump, upper limb, bilateral

  • R22.4|

    Localized swelling, mass and lump, lower limb

  • R22.40|

    Localized swelling, mass and lump, unspecified lower limb

  • R22.41|

    Localized swelling, mass and lump, right lower limb

  • R22.42|

    Localized swelling, mass and lump, left lower limb

  • R22.43|

    Localized swelling, mass and lump, lower limb, bilateral

  • R22.9|

    Localized swelling, mass and lump, unspecified

  • R23|

    Other skin changes

  • R23.0|

    Cyanosis

  • R23.1|

    Pallor

  • R23.2|

    Flushing

  • R23.3|

    Spontaneous ecchymoses

  • R23.4|

    Changes in skin texture

  • R23.8|

    Other skin changes

  • R23.9|

    Unspecified skin changes

  • R25|

    Abnormal involuntary movements

  • R25.0|

    Abnormal head movements

  • R25.1|

    Tremor, unspecified

  • R25.2|

    Cramp and spasm

  • R25.3|

    Fasciculation

  • R25.8|

    Other abnormal involuntary movements

  • R25.9|

    Unspecified abnormal involuntary movements

  • R26|

    Abnormalities of gait and mobility

  • R26.0|

    Ataxic gait

  • R26.1|

    Paralytic gait

  • R26.2|

    Difficulty in walking, not elsewhere classified

  • R26.8|

    Other abnormalities of gait and mobility

  • R26.81|

    Unsteadiness on feet

  • R26.89|

    Other abnormalities of gait and mobility

  • R26.9|

    Unspecified abnormalities of gait and mobility

  • R27|

    Other lack of coordination

  • R27.0|

    Ataxia, unspecified

  • R27.8|

    Other lack of coordination

  • R27.9|

    Unspecified lack of coordination

  • R29|

    Other symptoms and signs involving the nervous and musculoskeletal systems

  • R29.0|

    Tetany

  • R29.1|

    Meningismus

  • R29.2|

    Abnormal reflex

  • R29.3|

    Abnormal posture

  • R29.4|

    Clicking hip

  • R29.5|

    Transient paralysis

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