Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R40.211

    Coma scale, eyes open, never

  • R40.2110

    Coma scale, eyes open, never, unspecified time

  • R40.2111

    Coma scale, eyes open, never, in the field [EMT or ambulance]

  • R40.2112

    Coma scale, eyes open, never, at arrival to emergency department

  • R40.2113

    Coma scale, eyes open, never, at hospital admission

  • R40.2114

    Coma scale, eyes open, never, 24 hours or more after hospital admission

  • R40.212

    Coma scale, eyes open, to pain

  • R40.2120

    Coma scale, eyes open, to pain, unspecified time

  • R40.2121

    Coma scale, eyes open, to pain, in the field [EMT or ambulance]

  • R40.2122

    Coma scale, eyes open, to pain, at arrival to emergency department

  • R40.2123

    Coma scale, eyes open, to pain, at hospital admission

  • R40.2124

    Coma scale, eyes open, to pain, 24 hours or more after hospital admission

  • R40.213

    Coma scale, eyes open, to sound

  • R40.2130

    Coma scale, eyes open, to sound, unspecified time

  • R40.2131

    Coma scale, eyes open, to sound, in the field [EMT or ambulance]

  • R40.2132

    Coma scale, eyes open, to sound, at arrival to emergency department

  • R40.2133

    Coma scale, eyes open, to sound, at hospital admission

  • R40.2134

    Coma scale, eyes open, to sound, 24 hours or more after hospital admission

  • R40.214

    Coma scale, eyes open, spontaneous

  • R40.2140

    Coma scale, eyes open, spontaneous, unspecified time

  • R40.2141

    Coma scale, eyes open, spontaneous, in the field [EMT or ambulance]

  • R40.2142

    Coma scale, eyes open, spontaneous, at arrival to emergency department

  • R40.2143

    Coma scale, eyes open, spontaneous, at hospital admission

  • R40.2144

    Coma scale, eyes open, spontaneous, 24 hours or more after hospital admission

  • R40.221

    Coma scale, best verbal response, none

  • R40.2210

    Coma scale, best verbal response, none, unspecified time

  • R40.2211

    Coma scale, best verbal response, none, in the field [EMT or ambulance]

  • R40.2212

    Coma scale, best verbal response, none, at arrival to emergency department

  • R40.2213

    Coma scale, best verbal response, none, at hospital admission

  • R40.2214

    Coma scale, best verbal response, none, 24 hours or more after hospital admission

  • R40.222

    Coma scale, best verbal response, incomprehensible words

  • R40.2220

    Coma scale, best verbal response, incomprehensible words, unspecified time

  • R40.2221

    Coma scale, best verbal response, incomprehensible words, in the field [EMT or ambulance]

  • R40.2222

    Coma scale, best verbal response, incomprehensible words, at arrival to emergency department

  • R40.2223

    Coma scale, best verbal response, incomprehensible words, at hospital admission

  • R40.2224

    Coma scale, best verbal response, incomprehensible words, 24 hours or more after hospital admission

  • R40.223

    Coma scale, best verbal response, inappropriate words

  • R40.2230

    Coma scale, best verbal response, inappropriate words, unspecified time

  • R40.2231

    Coma scale, best verbal response, inappropriate words, in the field [EMT or ambulance]

  • R40.2232

    Coma scale, best verbal response, inappropriate words, at arrival to emergency department

  • R40.2233

    Coma scale, best verbal response, inappropriate words, at hospital admission

  • R40.2234

    Coma scale, best verbal response, inappropriate words, 24 hours or more after hospital admission

  • R40.224

    Coma scale, best verbal response, confused conversation

  • R40.2240

    Coma scale, best verbal response, confused conversation, unspecified time

  • R40.2241

    Coma scale, best verbal response, confused conversation, in the field [EMT or ambulance]

  • R40.2242

    Coma scale, best verbal response, confused conversation, at arrival to emergency department

  • R40.2243

    Coma scale, best verbal response, confused conversation, at hospital admission

  • R40.2244

    Coma scale, best verbal response, confused conversation, 24 hours or more after hospital admission

  • R40.225

    Coma scale, best verbal response, oriented

  • R40.2250

    Coma scale, best verbal response, oriented, unspecified time

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