Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R85.2

    Abnormal level of other drugs, medicaments and biological substances in specimens from digestive organs and abdominal cavity

  • R85.3

    Abnormal level of substances chiefly nonmedicinal as to source in specimens from digestive organs and abdominal cavity

  • R85.4

    Abnormal immunological findings in specimens from digestive organs and abdominal cavity

  • R85.5

    Abnormal microbiological findings in specimens from digestive organs and abdominal cavity

  • R85.610

    Atypical squamous cells of undetermined significance on cytologic smear of anus (ASC-US)

  • R85.611

    Atypical squamous cells cannot exclude high grade squamous intraepithelial lesion on cytologic smear of anus (ASC-H)

  • R85.612

    Low grade squamous intraepithelial lesion on cytologic smear of anus (LGSIL)

  • R85.613

    High grade squamous intraepithelial lesion on cytologic smear of anus (HGSIL)

  • R85.614

    Cytologic evidence of malignancy on smear of anus

  • R85.615

    Unsatisfactory cytologic smear of anus

  • R85.616

    Satisfactory anal smear but lacking transformation zone

  • R85.618

    Other abnormal cytological findings on specimens from anus

  • R85.619

    Unspecified abnormal cytological findings in specimens from anus

  • R85.69

    Abnormal cytological findings in specimens from other digestive organs and abdominal cavity

  • R85.7

    Abnormal histological findings in specimens from digestive organs and abdominal cavity

  • R85.81

    Anal high risk human papillomavirus (HPV) DNA test positive

  • R85.82

    Anal low risk human papillomavirus (HPV) DNA test positive

  • R85.89

    Other abnormal findings in specimens from digestive organs and abdominal cavity

  • R85.9

    Unspecified abnormal finding in specimens from digestive organs and abdominal cavity

  • R86.0

    Abnormal level of enzymes in specimens from male genital organs

  • R86.1

    Abnormal level of hormones in specimens from male genital organs

  • R86.2

    Abnormal level of other drugs, medicaments and biological substances in specimens from male genital organs

  • R86.3

    Abnormal level of substances chiefly nonmedicinal as to source in specimens from male genital organs

  • R86.4

    Abnormal immunological findings in specimens from male genital organs

  • R86.5

    Abnormal microbiological findings in specimens from male genital organs

  • R86.6

    Abnormal cytological findings in specimens from male genital organs

  • R86.7

    Abnormal histological findings in specimens from male genital organs

  • R86.8

    Other abnormal findings in specimens from male genital organs

  • R86.9

    Unspecified abnormal finding in specimens from male genital organs

  • R87.0

    Abnormal level of enzymes in specimens from female genital organs

  • R87.1

    Abnormal level of hormones in specimens from female genital organs

  • R87.2

    Abnormal level of other drugs, medicaments and biological substances in specimens from female genital organs

  • R87.3

    Abnormal level of substances chiefly nonmedicinal as to source in specimens from female genital organs

  • R87.4

    Abnormal immunological findings in specimens from female genital organs

  • R87.5

    Abnormal microbiological findings in specimens from female genital organs

  • R87.610

    Atypical squamous cells of undetermined significance on cytologic smear of cervix (ASC-US)

  • R87.611

    Atypical squamous cells cannot exclude high grade squamous intraepithelial lesion on cytologic smear of cervix (ASC-H)

  • R87.612

    Low grade squamous intraepithelial lesion on cytologic smear of cervix (LGSIL)

  • R87.613

    High grade squamous intraepithelial lesion on cytologic smear of cervix (HGSIL)

  • R87.614

    Cytologic evidence of malignancy on smear of cervix

  • R87.615

    Unsatisfactory cytologic smear of cervix

  • R87.616

    Satisfactory cervical smear but lacking transformation zone

  • R87.618

    Other abnormal cytological findings on specimens from cervix uteri

  • R87.619

    Unspecified abnormal cytological findings in specimens from cervix uteri

  • R87.620

    Atypical squamous cells of undetermined significance on cytologic smear of vagina (ASC-US)

  • R87.621

    Atypical squamous cells cannot exclude high grade squamous intraepithelial lesion on cytologic smear of vagina (ASC-H)

  • R87.622

    Low grade squamous intraepithelial lesion on cytologic smear of vagina (LGSIL)

  • R87.623

    High grade squamous intraepithelial lesion on cytologic smear of vagina (HGSIL)

  • R87.624

    Cytologic evidence of malignancy on smear of vagina

  • R87.625

    Unsatisfactory cytologic smear of vagina

PreviousPage 14 of 16Next