Chapter 18

R00–R99: Symptoms, Signs and Abnormal Clinical and Laboratory Findings

Symptoms, Signs and Abnormal Clinical and Laboratory Findings diagnostic classification updated for 2026.

Chapter Instructions

Excludes2(Not included here. Code separately if applicable.)
  • abnormal findings on antenatal screening of mother (O28.-)
  • certain conditions originating in the perinatal period (P04-P96)
  • signs and symptoms classified in the body system chapters
  • signs and symptoms of breast (N63, N64.5)
Internal Codes
  • R68.13

    Apparent life threatening event in infant (ALTE)

  • R68.19

    Other nonspecific symptoms peculiar to infancy

  • R68.2

    Dry mouth, unspecified

  • R68.3

    Clubbing of fingers

  • R68.81

    Early satiety

  • R68.82

    Decreased libido

  • R68.83

    Chills (without fever)

  • R68.84

    Jaw pain

  • R68.89

    Other general symptoms and signs

  • R69

    Illness, unspecified

  • R70.0

    Elevated erythrocyte sedimentation rate

  • R70.1

    Abnormal plasma viscosity

  • R71.0

    Precipitous drop in hematocrit

  • R71.8

    Other abnormality of red blood cells

  • R73.01

    Impaired fasting glucose

  • R73.02

    Impaired glucose tolerance (oral)

  • R73.03

    Prediabetes

  • R73.09

    Other abnormal glucose

  • R73.9

    Hyperglycemia, unspecified

  • R74.01

    Elevation of levels of liver transaminase levels

  • R74.02

    Elevation of levels of lactic acid dehydrogenase [LDH]

  • R74.8

    Abnormal levels of other serum enzymes

  • R74.9

    Abnormal serum enzyme level, unspecified

  • R75

    Inconclusive laboratory evidence of human immunodeficiency virus [HIV]

  • R76.0

    Raised antibody titer

  • R76.11

    Nonspecific reaction to tuberculin skin test without active tuberculosis

  • R76.12

    Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis

  • R76.81

    Abnormal rheumatoid factor and anti-citrullinated protein antibody without rheumatoid arthritis

  • R76.89

    Other specified abnormal immunological findings in serum

  • R76.9

    Abnormal immunological finding in serum, unspecified

  • R77.0

    Abnormality of albumin

  • R77.1

    Abnormality of globulin

  • R77.2

    Abnormality of alphafetoprotein

  • R77.8

    Other specified abnormalities of plasma proteins

  • R77.9

    Abnormality of plasma protein, unspecified

  • R78.0

    Finding of alcohol in blood

  • R78.1

    Finding of opiate drug in blood

  • R78.2

    Finding of cocaine in blood

  • R78.3

    Finding of hallucinogen in blood

  • R78.4

    Finding of other drugs of addictive potential in blood

  • R78.5

    Finding of other psychotropic drug in blood

  • R78.6

    Finding of steroid agent in blood

  • R78.71

    Abnormal lead level in blood

  • R78.79

    Finding of abnormal level of heavy metals in blood

  • R78.81

    Bacteremia

  • R78.89

    Finding of other specified substances, not normally found in blood

  • R78.9

    Finding of unspecified substance, not normally found in blood

  • R79.0

    Abnormal level of blood mineral

  • R79.1

    Abnormal coagulation profile

  • R79.81

    Abnormal blood-gas level

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