M35.81

Billable

ChapterM00–M99

Ranksubcategory

Official Description

Multisystem inflammatory syndrome

Metadata & Insights

•Billable/specific code (valid for reimbursement).
•Chapter 13: Diseases of the Musculoskeletal System and Connective Tissue (M00-M99).

Instructional Notes

Includes

MIS-A
MIS-C
Multisystem inflammatory syndrome in adults
Multisystem inflammatory syndrome in children
Pediatric inflammatory multisystem syndrome
PIMS

Code First

, if applicable, COVID-19 (U07.1)

Code Also

any associated complications such as:
acute hepatic failure (K72.0-)
acute kidney failure (N17.-)
acute myocarditis (I40.-)
acute respiratory distress syndrome (J80)
cardiac arrhythmia (I47-I49.-)
pneumonia due to COVID-19 (J12.82)
severe sepsis (R65.2-)
viral cardiomyopathy (B33.24)
viral pericarditis (B33.23)

Use Additional Code

code, if applicable, for:
exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
personal history of COVID-19 (Z86.16)
post COVID-19 condition (U09.9)

General instructions are available for the parent sections:

View CH13 Notes View M30-M36 Notes View M35 Notes

Clinical Hierarchy

BillableHas subcodes

CH13Diseases of the musculoskeletal system and connective tissue (M00-M99)

M30-M36Systemic connective tissue disorders (M30-M36)

M35Other systemic involvement of connective tissue

M35.8Other specified systemic involvement of connective tissue

M35.81Multisystem inflammatory syndromeBillable

Applicable Ancestor Context

The following parent sections contain instructions or notes that apply to M35.81:

categoryM35

Other systemic involvement of connective tissue

View context instructions

blockM30-M36

Systemic connective tissue disorders (M30-M36)

View context instructions

chapterCH13

Diseases of the musculoskeletal system and connective tissue (M00-M99)

View context instructions

Code History

FY 01/01/21: This code replaced M35.8 (Other specified systemic involvement of connective tissue)

MS-DRG Classification

2026 v43.1

This code is grouped within the following Diagnosis Related Group(s) for clinical reimbursement:

DRG 545

Connective Tissue Disorders with MCC

DRG 546

Connective Tissue Disorders with CC

DRG 547

Connective Tissue Disorders without CC/MCC

Cross Reference

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